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Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study. / Barber, N. J.; Zhang, X.; Zhu, G. et al.
In: Prostate Cancer and Prostatic Diseases, Vol. 9, No. 4, 12.2006, p. 407-413.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Barber, NJ, Zhang, X, Zhu, G, Pramanik, R, Barber, JA, Martin, FL, Morris, JDH & Muir, GH 2006, 'Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study.', Prostate Cancer and Prostatic Diseases, vol. 9, no. 4, pp. 407-413. https://doi.org/10.1038/sj.pcan.4500895

APA

Barber, N. J., Zhang, X., Zhu, G., Pramanik, R., Barber, J. A., Martin, F. L., Morris, J. D. H., & Muir, G. H. (2006). Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study. Prostate Cancer and Prostatic Diseases, 9(4), 407-413. https://doi.org/10.1038/sj.pcan.4500895

Vancouver

Barber NJ, Zhang X, Zhu G, Pramanik R, Barber JA, Martin FL et al. Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study. Prostate Cancer and Prostatic Diseases. 2006 Dec;9(4):407-413. doi: 10.1038/sj.pcan.4500895

Author

Barber, N. J. ; Zhang, X. ; Zhu, G. et al. / Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study. In: Prostate Cancer and Prostatic Diseases. 2006 ; Vol. 9, No. 4. pp. 407-413.

Bibtex

@article{3318abdd411f4c62a084762ec556acba,
title = "Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study.",
abstract = "Interest in lycopene has focused primarily on its use in the chemoprevention of prostate cancer (CaP); there are few clinical trials involving men with established disease. In addition, most data examining its mechanism of action have been obtained from experiments using immortal cell lines. We report the inhibitory effect(s) of lycopene in primary prostate epithelial cell (PEC) cultures, and the results of a pilot phase II clinical study investigating whole-tomato lycopene supplementation on the behavior of established CaP, demonstrating a significant and maintained effect on prostate-specific antigen velocity over 1 year. These data reinforce the justification for a large, randomized, placebo-controlled study.",
keywords = "prostate cancer, lycopene, diet",
author = "Barber, {N. J.} and X. Zhang and G. Zhu and R. Pramanik and Barber, {J. A.} and Martin, {Francis L.} and Morris, {J. D. H.} and Muir, {G. H.}",
year = "2006",
month = dec,
doi = "10.1038/sj.pcan.4500895",
language = "English",
volume = "9",
pages = "407--413",
journal = "Prostate Cancer and Prostatic Diseases",
issn = "1365-7852",
publisher = "Nature Publishing Group",
number = "4",

}

RIS

TY - JOUR

T1 - Lycopene inhibits DNA synthesis in primary prostate epithelial cells in vitro and its administration is associated with a reduced prostate-specific antigen velocity in a phase II clinical study.

AU - Barber, N. J.

AU - Zhang, X.

AU - Zhu, G.

AU - Pramanik, R.

AU - Barber, J. A.

AU - Martin, Francis L.

AU - Morris, J. D. H.

AU - Muir, G. H.

PY - 2006/12

Y1 - 2006/12

N2 - Interest in lycopene has focused primarily on its use in the chemoprevention of prostate cancer (CaP); there are few clinical trials involving men with established disease. In addition, most data examining its mechanism of action have been obtained from experiments using immortal cell lines. We report the inhibitory effect(s) of lycopene in primary prostate epithelial cell (PEC) cultures, and the results of a pilot phase II clinical study investigating whole-tomato lycopene supplementation on the behavior of established CaP, demonstrating a significant and maintained effect on prostate-specific antigen velocity over 1 year. These data reinforce the justification for a large, randomized, placebo-controlled study.

AB - Interest in lycopene has focused primarily on its use in the chemoprevention of prostate cancer (CaP); there are few clinical trials involving men with established disease. In addition, most data examining its mechanism of action have been obtained from experiments using immortal cell lines. We report the inhibitory effect(s) of lycopene in primary prostate epithelial cell (PEC) cultures, and the results of a pilot phase II clinical study investigating whole-tomato lycopene supplementation on the behavior of established CaP, demonstrating a significant and maintained effect on prostate-specific antigen velocity over 1 year. These data reinforce the justification for a large, randomized, placebo-controlled study.

KW - prostate cancer

KW - lycopene

KW - diet

U2 - 10.1038/sj.pcan.4500895

DO - 10.1038/sj.pcan.4500895

M3 - Journal article

VL - 9

SP - 407

EP - 413

JO - Prostate Cancer and Prostatic Diseases

JF - Prostate Cancer and Prostatic Diseases

SN - 1365-7852

IS - 4

ER -