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Lysine metabolism in higher plants.

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Lysine metabolism in higher plants. / Azevedo, R. A.; Lea, P. J.
In: Amino Acids, Vol. 20, No. 3, 04.2001, p. 261-279.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Azevedo, RA & Lea, PJ 2001, 'Lysine metabolism in higher plants.', Amino Acids, vol. 20, no. 3, pp. 261-279. https://doi.org/10.1007/s007260170043

APA

Azevedo, R. A., & Lea, P. J. (2001). Lysine metabolism in higher plants. Amino Acids, 20(3), 261-279. https://doi.org/10.1007/s007260170043

Vancouver

Azevedo RA, Lea PJ. Lysine metabolism in higher plants. Amino Acids. 2001 Apr;20(3):261-279. doi: 10.1007/s007260170043

Author

Azevedo, R. A. ; Lea, P. J. / Lysine metabolism in higher plants. In: Amino Acids. 2001 ; Vol. 20, No. 3. pp. 261-279.

Bibtex

@article{75fff24b25764c1c8cddc0c3cf65b640,
title = "Lysine metabolism in higher plants.",
abstract = "The essential amino acid lysine is synthesised in higher plants via a pathway starting with aspartate, that also leads to the formation of threonine, methionine and isoleucine. Enzyme kinetic studies and the analysis of mutants and transgenic plants that overaccumulate lysine, have indicated that the major site of the regulation of lysine synthesis is at the enzyme dihydrodipicolinate synthase. Despite this tight regulation, there is strong evidence that lysine is also subject to catabolism in plants, specifically in the seed. The two enzymes involved in lysine breakdown, lysine 2-oxoglutarate reductase (also known as lysine α-ketoglutarate reductase) and saccharopine dehydrogenase exist as a single bifunctional protein, with the former activity being regulated by lysine availability, calcium and phosphorylation/dephosphorylation.",
keywords = "Amino acids - Aspartate kinase - Aspartate - Lysine synthesis - Lysine 2-oxoglutarate reductase - Methionine - Threonine",
author = "Azevedo, {R. A.} and Lea, {P. J.}",
year = "2001",
month = apr,
doi = "10.1007/s007260170043",
language = "English",
volume = "20",
pages = "261--279",
journal = "Amino Acids",
issn = "0939-4451",
publisher = "Springer Wien",
number = "3",

}

RIS

TY - JOUR

T1 - Lysine metabolism in higher plants.

AU - Azevedo, R. A.

AU - Lea, P. J.

PY - 2001/4

Y1 - 2001/4

N2 - The essential amino acid lysine is synthesised in higher plants via a pathway starting with aspartate, that also leads to the formation of threonine, methionine and isoleucine. Enzyme kinetic studies and the analysis of mutants and transgenic plants that overaccumulate lysine, have indicated that the major site of the regulation of lysine synthesis is at the enzyme dihydrodipicolinate synthase. Despite this tight regulation, there is strong evidence that lysine is also subject to catabolism in plants, specifically in the seed. The two enzymes involved in lysine breakdown, lysine 2-oxoglutarate reductase (also known as lysine α-ketoglutarate reductase) and saccharopine dehydrogenase exist as a single bifunctional protein, with the former activity being regulated by lysine availability, calcium and phosphorylation/dephosphorylation.

AB - The essential amino acid lysine is synthesised in higher plants via a pathway starting with aspartate, that also leads to the formation of threonine, methionine and isoleucine. Enzyme kinetic studies and the analysis of mutants and transgenic plants that overaccumulate lysine, have indicated that the major site of the regulation of lysine synthesis is at the enzyme dihydrodipicolinate synthase. Despite this tight regulation, there is strong evidence that lysine is also subject to catabolism in plants, specifically in the seed. The two enzymes involved in lysine breakdown, lysine 2-oxoglutarate reductase (also known as lysine α-ketoglutarate reductase) and saccharopine dehydrogenase exist as a single bifunctional protein, with the former activity being regulated by lysine availability, calcium and phosphorylation/dephosphorylation.

KW - Amino acids - Aspartate kinase - Aspartate - Lysine synthesis - Lysine 2-oxoglutarate reductase - Methionine - Threonine

U2 - 10.1007/s007260170043

DO - 10.1007/s007260170043

M3 - Journal article

VL - 20

SP - 261

EP - 279

JO - Amino Acids

JF - Amino Acids

SN - 0939-4451

IS - 3

ER -