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    Rights statement: © Knight et al; licensee BioMed Central Ltd 2003 This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mapping loci influencing blood pressure in the Framingham pedigrees using model-free LOD score analysis of a quantitative trait

Research output: Contribution to journalJournal article

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  • Jo Knight
  • Bernard V. North
  • Pak C. Sham
  • David Curtis
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Article numberS74
<mark>Journal publication date</mark>31/12/2003
<mark>Journal</mark>Genetics
Issue numberSuppl. 1
Volume4
Number of pages4
Publication statusPublished
Original languageEnglish

Abstract

This paper presents a method of performing model-free LOD-score based linkage analysis on quantitative traits. It is implemented in the QMFLINK program. The method is used to perform a genome screen on the Framingham Heart Study data. A number of markers that show some support for linkage in our study coincide substantially with those implicated in other linkage studies of hypertension. Although the new method needs further testing on additional real and simulated data sets we can already say that it is straightforward to apply and may offer a useful complementary approach to previously available methods for the linkage analysis of quantitative traits.

Bibliographic note

© Knight et al; licensee BioMed Central Ltd 2003 This article is published under license to BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.