Home > Research > Publications & Outputs > Mapping the geographical distribution of podoco...

Links

Text available via DOI:

View graph of relations

Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema

Research output: Contribution to journalJournal article

Published

Standard

Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema. / Deribe, Kebede; Beng, Amuam Andrew; Cano, Jorge; Njouendo, Abdel Jelil; Fru-Cho, Jerome; Awah, Abong Raphael; Eyong, Matthias Esum; Chounna Ndongmo, Patrick W.; Giorgi, Emanuele; Pigott, David M.; Golding, Nick ; Pullan, Rachel L.; Noor, Abdisalan M.; Enquselassie, Fikre; Murray, Christopher J. L.; Brooker, Simon J.; Hay, Simon I.; Enyong, Peter; Newport, Melanie J.; Wanji, Samuel; Davey, Gail.

In: PLoS Neglected Tropical Diseases, Vol. 12, No. 1, e0006126, 11.01.2018.

Research output: Contribution to journalJournal article

Harvard

Deribe, K, Beng, AA, Cano, J, Njouendo, AJ, Fru-Cho, J, Awah, AR, Eyong, ME, Chounna Ndongmo, PW, Giorgi, E, Pigott, DM, Golding, N, Pullan, RL, Noor, AM, Enquselassie, F, Murray, CJL, Brooker, SJ, Hay, SI, Enyong, P, Newport, MJ, Wanji, S & Davey, G 2018, 'Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema', PLoS Neglected Tropical Diseases, vol. 12, no. 1, e0006126. https://doi.org/10.1371/journal.pntd.0006126

APA

Deribe, K., Beng, A. A., Cano, J., Njouendo, A. J., Fru-Cho, J., Awah, A. R., Eyong, M. E., Chounna Ndongmo, P. W., Giorgi, E., Pigott, D. M., Golding, N., Pullan, R. L., Noor, A. M., Enquselassie, F., Murray, C. J. L., Brooker, S. J., Hay, S. I., Enyong, P., Newport, M. J., ... Davey, G. (2018). Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema. PLoS Neglected Tropical Diseases, 12(1), [e0006126]. https://doi.org/10.1371/journal.pntd.0006126

Vancouver

Author

Deribe, Kebede ; Beng, Amuam Andrew ; Cano, Jorge ; Njouendo, Abdel Jelil ; Fru-Cho, Jerome ; Awah, Abong Raphael ; Eyong, Matthias Esum ; Chounna Ndongmo, Patrick W. ; Giorgi, Emanuele ; Pigott, David M. ; Golding, Nick ; Pullan, Rachel L. ; Noor, Abdisalan M. ; Enquselassie, Fikre ; Murray, Christopher J. L. ; Brooker, Simon J. ; Hay, Simon I. ; Enyong, Peter ; Newport, Melanie J. ; Wanji, Samuel ; Davey, Gail. / Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema. In: PLoS Neglected Tropical Diseases. 2018 ; Vol. 12, No. 1.

Bibtex

@article{f80f50c85d3d45eaa96a160d7c201c03,
title = "Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema",
abstract = "BackgroundPodoconiosis is a non-filarial elephantiasis, which causes massive swelling of the lower legs. It was identified as a neglected tropical disease by WHO in 2011. Understanding of the geographical distribution of the disease is incomplete. As part of a global mapping of podoconiosis, this study was conducted in Cameroon to map the distribution of the disease. This mapping work will help to generate data on the geographical distribution of podoconiosis in Cameroon and contribute to the global atlas of podoconiosis.MethodsWe used a multi‐stage sampling design with stratification of the country by environmental risk of podoconiosis. We sampled 76 villages from 40 health districts from the ten Regions of Cameroon. All individuals of 15-years old or older in the village were surveyed house-to-house and screened for lymphedema. A clinical algorithm was used to reliably diagnose podoconiosis, excluding filarial-associated lymphedema. Individuals with lymphoedema were tested for circulating Wuchereria bancrofti antigen and specific IgG4 using the Alere Filariasis Test Strips (FTS) test and the Standard Diagnostics (SD) BIOLINE lymphatic filariasis IgG4 test (Wb123) respectively, in addition to thick blood films. Presence of DNA specific to W. bancrofti was checked on night blood using a qPCR technique.Principal findingsOverall, 10,178 individuals from 4,603 households participated in the study. In total, 83 individuals with lymphedema were identified. Of the 83 individuals with lymphedema, two were found to be FTS positive and all were negative using the Wb123 test. No microfilaria of W. bancrofti were found in the night blood of any individual with clinical lymphedema. None were found to be positive for W. bancrofti using qPCR. Of the two FTS positive cases, one was positive for Mansonella perstans DNA, while the other harbored Loa loa microfilaria. Overall, 52 people with podoconiosis were identified after applying the clinical algorithm. The overall prevalence of podoconiosis was found to be 0.5% (95% [confidence interval] CI; 0.4–0.7). At least one case of podoconiosis was found in every region of Cameroon except the two surveyed villages in Adamawa. Of the 40 health districts surveyed, 17 districts had no cases of podoconiosis; in 15 districts, mean prevalence was between 0.2% and 1.0%; and in the remaining eight, mean prevalence was between 1.2% and 2.7%.ConclusionsOur investigation has demonstrated low prevalence but almost nationwide distribution of podoconiosis in Cameroon. Designing a podoconiosis control program is a vital next step. A health system response to the burden of podoconiosis is important, through case surveillance and morbidity management services.",
author = "Kebede Deribe and Beng, {Amuam Andrew} and Jorge Cano and Njouendo, {Abdel Jelil} and Jerome Fru-Cho and Awah, {Abong Raphael} and Eyong, {Matthias Esum} and {Chounna Ndongmo}, {Patrick W.} and Emanuele Giorgi and Pigott, {David M.} and Nick Golding and Pullan, {Rachel L.} and Noor, {Abdisalan M.} and Fikre Enquselassie and Murray, {Christopher J. L.} and Brooker, {Simon J.} and Hay, {Simon I.} and Peter Enyong and Newport, {Melanie J.} and Samuel Wanji and Gail Davey",
note = "{\textcopyright} 2018 Deribe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited",
year = "2018",
month = jan
day = "11",
doi = "10.1371/journal.pntd.0006126",
language = "English",
volume = "12",
journal = "PLoS Neglected Tropical Diseases",
issn = "1935-2727",
publisher = "Public Library of Science",
number = "1",

}

RIS

TY - JOUR

T1 - Mapping the geographical distribution of podoconiosis in Cameroon using parasitological, serological, and clinical evidence to exclude other causes of lymphedema

AU - Deribe, Kebede

AU - Beng, Amuam Andrew

AU - Cano, Jorge

AU - Njouendo, Abdel Jelil

AU - Fru-Cho, Jerome

AU - Awah, Abong Raphael

AU - Eyong, Matthias Esum

AU - Chounna Ndongmo, Patrick W.

AU - Giorgi, Emanuele

AU - Pigott, David M.

AU - Golding, Nick

AU - Pullan, Rachel L.

AU - Noor, Abdisalan M.

AU - Enquselassie, Fikre

AU - Murray, Christopher J. L.

AU - Brooker, Simon J.

AU - Hay, Simon I.

AU - Enyong, Peter

AU - Newport, Melanie J.

AU - Wanji, Samuel

AU - Davey, Gail

N1 - © 2018 Deribe et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

PY - 2018/1/11

Y1 - 2018/1/11

N2 - BackgroundPodoconiosis is a non-filarial elephantiasis, which causes massive swelling of the lower legs. It was identified as a neglected tropical disease by WHO in 2011. Understanding of the geographical distribution of the disease is incomplete. As part of a global mapping of podoconiosis, this study was conducted in Cameroon to map the distribution of the disease. This mapping work will help to generate data on the geographical distribution of podoconiosis in Cameroon and contribute to the global atlas of podoconiosis.MethodsWe used a multi‐stage sampling design with stratification of the country by environmental risk of podoconiosis. We sampled 76 villages from 40 health districts from the ten Regions of Cameroon. All individuals of 15-years old or older in the village were surveyed house-to-house and screened for lymphedema. A clinical algorithm was used to reliably diagnose podoconiosis, excluding filarial-associated lymphedema. Individuals with lymphoedema were tested for circulating Wuchereria bancrofti antigen and specific IgG4 using the Alere Filariasis Test Strips (FTS) test and the Standard Diagnostics (SD) BIOLINE lymphatic filariasis IgG4 test (Wb123) respectively, in addition to thick blood films. Presence of DNA specific to W. bancrofti was checked on night blood using a qPCR technique.Principal findingsOverall, 10,178 individuals from 4,603 households participated in the study. In total, 83 individuals with lymphedema were identified. Of the 83 individuals with lymphedema, two were found to be FTS positive and all were negative using the Wb123 test. No microfilaria of W. bancrofti were found in the night blood of any individual with clinical lymphedema. None were found to be positive for W. bancrofti using qPCR. Of the two FTS positive cases, one was positive for Mansonella perstans DNA, while the other harbored Loa loa microfilaria. Overall, 52 people with podoconiosis were identified after applying the clinical algorithm. The overall prevalence of podoconiosis was found to be 0.5% (95% [confidence interval] CI; 0.4–0.7). At least one case of podoconiosis was found in every region of Cameroon except the two surveyed villages in Adamawa. Of the 40 health districts surveyed, 17 districts had no cases of podoconiosis; in 15 districts, mean prevalence was between 0.2% and 1.0%; and in the remaining eight, mean prevalence was between 1.2% and 2.7%.ConclusionsOur investigation has demonstrated low prevalence but almost nationwide distribution of podoconiosis in Cameroon. Designing a podoconiosis control program is a vital next step. A health system response to the burden of podoconiosis is important, through case surveillance and morbidity management services.

AB - BackgroundPodoconiosis is a non-filarial elephantiasis, which causes massive swelling of the lower legs. It was identified as a neglected tropical disease by WHO in 2011. Understanding of the geographical distribution of the disease is incomplete. As part of a global mapping of podoconiosis, this study was conducted in Cameroon to map the distribution of the disease. This mapping work will help to generate data on the geographical distribution of podoconiosis in Cameroon and contribute to the global atlas of podoconiosis.MethodsWe used a multi‐stage sampling design with stratification of the country by environmental risk of podoconiosis. We sampled 76 villages from 40 health districts from the ten Regions of Cameroon. All individuals of 15-years old or older in the village were surveyed house-to-house and screened for lymphedema. A clinical algorithm was used to reliably diagnose podoconiosis, excluding filarial-associated lymphedema. Individuals with lymphoedema were tested for circulating Wuchereria bancrofti antigen and specific IgG4 using the Alere Filariasis Test Strips (FTS) test and the Standard Diagnostics (SD) BIOLINE lymphatic filariasis IgG4 test (Wb123) respectively, in addition to thick blood films. Presence of DNA specific to W. bancrofti was checked on night blood using a qPCR technique.Principal findingsOverall, 10,178 individuals from 4,603 households participated in the study. In total, 83 individuals with lymphedema were identified. Of the 83 individuals with lymphedema, two were found to be FTS positive and all were negative using the Wb123 test. No microfilaria of W. bancrofti were found in the night blood of any individual with clinical lymphedema. None were found to be positive for W. bancrofti using qPCR. Of the two FTS positive cases, one was positive for Mansonella perstans DNA, while the other harbored Loa loa microfilaria. Overall, 52 people with podoconiosis were identified after applying the clinical algorithm. The overall prevalence of podoconiosis was found to be 0.5% (95% [confidence interval] CI; 0.4–0.7). At least one case of podoconiosis was found in every region of Cameroon except the two surveyed villages in Adamawa. Of the 40 health districts surveyed, 17 districts had no cases of podoconiosis; in 15 districts, mean prevalence was between 0.2% and 1.0%; and in the remaining eight, mean prevalence was between 1.2% and 2.7%.ConclusionsOur investigation has demonstrated low prevalence but almost nationwide distribution of podoconiosis in Cameroon. Designing a podoconiosis control program is a vital next step. A health system response to the burden of podoconiosis is important, through case surveillance and morbidity management services.

U2 - 10.1371/journal.pntd.0006126

DO - 10.1371/journal.pntd.0006126

M3 - Journal article

VL - 12

JO - PLoS Neglected Tropical Diseases

JF - PLoS Neglected Tropical Diseases

SN - 1935-2727

IS - 1

M1 - e0006126

ER -