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Measurement of abnormal bone composition in vivo using noninvasive Raman spectroscopy

Research output: Contribution to journalJournal article

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Measurement of abnormal bone composition in vivo using noninvasive Raman spectroscopy. / Buckley, Kevin; Kerns, Jemma; Gikas, Panagiotis D.; Birch, Helen; Vinton, Jacqueline; Keen, Richard; Parker, Anthony W.; Matousek, Pavel; Goodship, Allen.

In: IBMS BoneKEy, Vol. 11, 602, 26.11.2014, p. 1-3.

Research output: Contribution to journalJournal article

Harvard

Buckley, K, Kerns, J, Gikas, PD, Birch, H, Vinton, J, Keen, R, Parker, AW, Matousek, P & Goodship, A 2014, 'Measurement of abnormal bone composition in vivo using noninvasive Raman spectroscopy', IBMS BoneKEy, vol. 11, 602, pp. 1-3. https://doi.org/10.1038/bonekey.2014.97

APA

Buckley, K., Kerns, J., Gikas, P. D., Birch, H., Vinton, J., Keen, R., ... Goodship, A. (2014). Measurement of abnormal bone composition in vivo using noninvasive Raman spectroscopy. IBMS BoneKEy, 11, 1-3. [602]. https://doi.org/10.1038/bonekey.2014.97

Vancouver

Buckley K, Kerns J, Gikas PD, Birch H, Vinton J, Keen R et al. Measurement of abnormal bone composition in vivo using noninvasive Raman spectroscopy. IBMS BoneKEy. 2014 Nov 26;11:1-3. 602. https://doi.org/10.1038/bonekey.2014.97

Author

Buckley, Kevin ; Kerns, Jemma ; Gikas, Panagiotis D. ; Birch, Helen ; Vinton, Jacqueline ; Keen, Richard ; Parker, Anthony W. ; Matousek, Pavel ; Goodship, Allen. / Measurement of abnormal bone composition in vivo using noninvasive Raman spectroscopy. In: IBMS BoneKEy. 2014 ; Vol. 11. pp. 1-3.

Bibtex

@article{ce878f9980a644c7917cda9ce0505e1c,
title = "Measurement of abnormal bone composition in vivo using noninvasive Raman spectroscopy",
abstract = "X-ray-based diagnostic techniques, which are by far the most widely used for diagnosing bone disorders and diseases, are largely blind to the protein component of bone. Bone proteins are important because they determine certainmechanical properties of bone and changes in the proteins have been associated with a number of bone diseases. Spatially Offset Raman Spectroscopy (SORS) is a chemically specific analytical technique that can be used to retrieve information noninvasively from both the mineral and protein phases of the bone material in vivo. Here we demonstrate that SORS can be used to detect a known compositional abnormality in the bones of a patient suffering from the geneticbone disorder, osteogenesis imperfecta, a condition which affects collagen. The confirmation of the principle that bone diseases in living patients can be detected noninvasively using SORS points the way to larger studies that focus on osteoporosis and other chronic debilitating bone diseases with large socioeconomic burdens.",
author = "Kevin Buckley and Jemma Kerns and Gikas, {Panagiotis D.} and Helen Birch and Jacqueline Vinton and Richard Keen and Parker, {Anthony W.} and Pavel Matousek and Allen Goodship",
note = "This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http:// creativecommons.org/licenses/by/3.0/",
year = "2014",
month = "11",
day = "26",
doi = "10.1038/bonekey.2014.97",
language = "English",
volume = "11",
pages = "1--3",
journal = "IBMS BoneKEy",
issn = "1940-8692",

}

RIS

TY - JOUR

T1 - Measurement of abnormal bone composition in vivo using noninvasive Raman spectroscopy

AU - Buckley, Kevin

AU - Kerns, Jemma

AU - Gikas, Panagiotis D.

AU - Birch, Helen

AU - Vinton, Jacqueline

AU - Keen, Richard

AU - Parker, Anthony W.

AU - Matousek, Pavel

AU - Goodship, Allen

N1 - This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http:// creativecommons.org/licenses/by/3.0/

PY - 2014/11/26

Y1 - 2014/11/26

N2 - X-ray-based diagnostic techniques, which are by far the most widely used for diagnosing bone disorders and diseases, are largely blind to the protein component of bone. Bone proteins are important because they determine certainmechanical properties of bone and changes in the proteins have been associated with a number of bone diseases. Spatially Offset Raman Spectroscopy (SORS) is a chemically specific analytical technique that can be used to retrieve information noninvasively from both the mineral and protein phases of the bone material in vivo. Here we demonstrate that SORS can be used to detect a known compositional abnormality in the bones of a patient suffering from the geneticbone disorder, osteogenesis imperfecta, a condition which affects collagen. The confirmation of the principle that bone diseases in living patients can be detected noninvasively using SORS points the way to larger studies that focus on osteoporosis and other chronic debilitating bone diseases with large socioeconomic burdens.

AB - X-ray-based diagnostic techniques, which are by far the most widely used for diagnosing bone disorders and diseases, are largely blind to the protein component of bone. Bone proteins are important because they determine certainmechanical properties of bone and changes in the proteins have been associated with a number of bone diseases. Spatially Offset Raman Spectroscopy (SORS) is a chemically specific analytical technique that can be used to retrieve information noninvasively from both the mineral and protein phases of the bone material in vivo. Here we demonstrate that SORS can be used to detect a known compositional abnormality in the bones of a patient suffering from the geneticbone disorder, osteogenesis imperfecta, a condition which affects collagen. The confirmation of the principle that bone diseases in living patients can be detected noninvasively using SORS points the way to larger studies that focus on osteoporosis and other chronic debilitating bone diseases with large socioeconomic burdens.

U2 - 10.1038/bonekey.2014.97

DO - 10.1038/bonekey.2014.97

M3 - Journal article

VL - 11

SP - 1

EP - 3

JO - IBMS BoneKEy

JF - IBMS BoneKEy

SN - 1940-8692

M1 - 602

ER -