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Mechanical properties of alginate hydrogels manufactured using external gelation

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Mechanical properties of alginate hydrogels manufactured using external gelation. / Kaklamani, Georgina; Cheneler, David; Grover, Liam et al.
In: Journal of the Mechanical Behavior of Biomedical Materials, Vol. 36, 08.2014, p. 135-142.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Kaklamani, G, Cheneler, D, Grover, L, Adams, M & Bowen, J 2014, 'Mechanical properties of alginate hydrogels manufactured using external gelation', Journal of the Mechanical Behavior of Biomedical Materials, vol. 36, pp. 135-142. https://doi.org/10.1016/j.jmbbm.2014.04.013

APA

Kaklamani, G., Cheneler, D., Grover, L., Adams, M., & Bowen, J. (2014). Mechanical properties of alginate hydrogels manufactured using external gelation. Journal of the Mechanical Behavior of Biomedical Materials, 36, 135-142. https://doi.org/10.1016/j.jmbbm.2014.04.013

Vancouver

Kaklamani G, Cheneler D, Grover L, Adams M, Bowen J. Mechanical properties of alginate hydrogels manufactured using external gelation. Journal of the Mechanical Behavior of Biomedical Materials. 2014 Aug;36:135-142. Epub 2014 May 4. doi: 10.1016/j.jmbbm.2014.04.013

Author

Kaklamani, Georgina ; Cheneler, David ; Grover, Liam et al. / Mechanical properties of alginate hydrogels manufactured using external gelation. In: Journal of the Mechanical Behavior of Biomedical Materials. 2014 ; Vol. 36. pp. 135-142.

Bibtex

@article{ae3e051b6dd14a01ad7a9055c3b5f388,
title = "Mechanical properties of alginate hydrogels manufactured using external gelation",
abstract = "Alginate hydrogels are commonly used in biomedical applications such as scaffolds for tissue engineering, drug delivery, and as a medium for cell immobilization. Multivalent cations are often employed to create physical crosslinks between carboxyl and hydroxyl moieties on neighbouring polysaccharide chains, creating hydrogels with a range of mechanical properties. This work describes the manufacture and characterisation of sodium alginate hydrogels using the divalent cations Mg2+, Ca2+ and Sr2+ to promote gelation via non-covalent crosslinks. The gelation time and Young's modulus are characterised as a function of cation and alginate concentrations. The implications of this work towards the use of environmental elasticity to control stem cell differentiation are discussed.",
keywords = "Alginate, Calcium , Cation, Hydrogel, Indentation, Magnesium, Modulus , Strontium",
author = "Georgina Kaklamani and David Cheneler and Liam Grover and Mike Adams and James Bowen",
year = "2014",
month = aug,
doi = "10.1016/j.jmbbm.2014.04.013",
language = "English",
volume = "36",
pages = "135--142",
journal = "Journal of the Mechanical Behavior of Biomedical Materials",
issn = "1751-6161",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Mechanical properties of alginate hydrogels manufactured using external gelation

AU - Kaklamani, Georgina

AU - Cheneler, David

AU - Grover, Liam

AU - Adams, Mike

AU - Bowen, James

PY - 2014/8

Y1 - 2014/8

N2 - Alginate hydrogels are commonly used in biomedical applications such as scaffolds for tissue engineering, drug delivery, and as a medium for cell immobilization. Multivalent cations are often employed to create physical crosslinks between carboxyl and hydroxyl moieties on neighbouring polysaccharide chains, creating hydrogels with a range of mechanical properties. This work describes the manufacture and characterisation of sodium alginate hydrogels using the divalent cations Mg2+, Ca2+ and Sr2+ to promote gelation via non-covalent crosslinks. The gelation time and Young's modulus are characterised as a function of cation and alginate concentrations. The implications of this work towards the use of environmental elasticity to control stem cell differentiation are discussed.

AB - Alginate hydrogels are commonly used in biomedical applications such as scaffolds for tissue engineering, drug delivery, and as a medium for cell immobilization. Multivalent cations are often employed to create physical crosslinks between carboxyl and hydroxyl moieties on neighbouring polysaccharide chains, creating hydrogels with a range of mechanical properties. This work describes the manufacture and characterisation of sodium alginate hydrogels using the divalent cations Mg2+, Ca2+ and Sr2+ to promote gelation via non-covalent crosslinks. The gelation time and Young's modulus are characterised as a function of cation and alginate concentrations. The implications of this work towards the use of environmental elasticity to control stem cell differentiation are discussed.

KW - Alginate

KW - Calcium

KW - Cation

KW - Hydrogel

KW - Indentation

KW - Magnesium

KW - Modulus

KW - Strontium

U2 - 10.1016/j.jmbbm.2014.04.013

DO - 10.1016/j.jmbbm.2014.04.013

M3 - Journal article

VL - 36

SP - 135

EP - 142

JO - Journal of the Mechanical Behavior of Biomedical Materials

JF - Journal of the Mechanical Behavior of Biomedical Materials

SN - 1751-6161

ER -