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Mechanistic insights into nanotoxicity determined by synchrotron radiation-based Fourier-transform infrared imaging and multivariate analysis

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Mechanistic insights into nanotoxicity determined by synchrotron radiation-based Fourier-transform infrared imaging and multivariate analysis. / Riding, Matthew J.; Trevisan, Júlio; Hirschmugl, Carol J. et al.
In: Environment International, Vol. 50, 01.12.2012, p. 56-65.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Riding, MJ, Trevisan, J, Hirschmugl, CJ, Jones, KC, Semple, KT & Martin, FL 2012, 'Mechanistic insights into nanotoxicity determined by synchrotron radiation-based Fourier-transform infrared imaging and multivariate analysis', Environment International, vol. 50, pp. 56-65. https://doi.org/10.1016/j.envint.2012.09.009

APA

Riding, M. J., Trevisan, J., Hirschmugl, C. J., Jones, K. C., Semple, K. T., & Martin, F. L. (2012). Mechanistic insights into nanotoxicity determined by synchrotron radiation-based Fourier-transform infrared imaging and multivariate analysis. Environment International, 50, 56-65. https://doi.org/10.1016/j.envint.2012.09.009

Vancouver

Riding MJ, Trevisan J, Hirschmugl CJ, Jones KC, Semple KT, Martin FL. Mechanistic insights into nanotoxicity determined by synchrotron radiation-based Fourier-transform infrared imaging and multivariate analysis. Environment International. 2012 Dec 1;50:56-65. doi: 10.1016/j.envint.2012.09.009

Author

Riding, Matthew J. ; Trevisan, Júlio ; Hirschmugl, Carol J. et al. / Mechanistic insights into nanotoxicity determined by synchrotron radiation-based Fourier-transform infrared imaging and multivariate analysis. In: Environment International. 2012 ; Vol. 50. pp. 56-65.

Bibtex

@article{88f564010b514743acc7f435c5a70e2f,
title = "Mechanistic insights into nanotoxicity determined by synchrotron radiation-based Fourier-transform infrared imaging and multivariate analysis",
abstract = "Our ability to identify the mechanisms by which carbon-based nanomaterials (CBNs) exert toxicity in cells is constrained by the lack of standardized methodologies to assay endpoint effects. Herein we describe a method of mechanistically identifying the effects of various CBN types in both prokaryotic and eukaryotic cells using multi-beam synchrotron radiation-based Fourier-transform infrared imaging (SR-FTIRI) at diffraction-limited resolution. This technique overcomes many of the inherent difficulties of assaying nanotoxicity and demonstrates exceptional sensitivity in identifying the effects of CBNs in cells at environmentally-relevant concentrations. We identify key mechanisms of nanotoxicity as the alteration of Amide and lipid biomolecules, but propose more specific bioactivity of CBNs occurs as a result of specific interactions between CBN structural conformation and cellular characteristics.",
keywords = "Carbon nanoparticles, Multivariate analysis, Nanotoxicity , Spectroscopy , Synchrotron radiation",
author = "Riding, {Matthew J.} and J{\'u}lio Trevisan and Hirschmugl, {Carol J.} and Jones, {Kevin C.} and Semple, {Kirk T.} and Martin, {Francis L.}",
year = "2012",
month = dec,
day = "1",
doi = "10.1016/j.envint.2012.09.009",
language = "English",
volume = "50",
pages = "56--65",
journal = "Environment International",
issn = "0160-4120",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Mechanistic insights into nanotoxicity determined by synchrotron radiation-based Fourier-transform infrared imaging and multivariate analysis

AU - Riding, Matthew J.

AU - Trevisan, Júlio

AU - Hirschmugl, Carol J.

AU - Jones, Kevin C.

AU - Semple, Kirk T.

AU - Martin, Francis L.

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Our ability to identify the mechanisms by which carbon-based nanomaterials (CBNs) exert toxicity in cells is constrained by the lack of standardized methodologies to assay endpoint effects. Herein we describe a method of mechanistically identifying the effects of various CBN types in both prokaryotic and eukaryotic cells using multi-beam synchrotron radiation-based Fourier-transform infrared imaging (SR-FTIRI) at diffraction-limited resolution. This technique overcomes many of the inherent difficulties of assaying nanotoxicity and demonstrates exceptional sensitivity in identifying the effects of CBNs in cells at environmentally-relevant concentrations. We identify key mechanisms of nanotoxicity as the alteration of Amide and lipid biomolecules, but propose more specific bioactivity of CBNs occurs as a result of specific interactions between CBN structural conformation and cellular characteristics.

AB - Our ability to identify the mechanisms by which carbon-based nanomaterials (CBNs) exert toxicity in cells is constrained by the lack of standardized methodologies to assay endpoint effects. Herein we describe a method of mechanistically identifying the effects of various CBN types in both prokaryotic and eukaryotic cells using multi-beam synchrotron radiation-based Fourier-transform infrared imaging (SR-FTIRI) at diffraction-limited resolution. This technique overcomes many of the inherent difficulties of assaying nanotoxicity and demonstrates exceptional sensitivity in identifying the effects of CBNs in cells at environmentally-relevant concentrations. We identify key mechanisms of nanotoxicity as the alteration of Amide and lipid biomolecules, but propose more specific bioactivity of CBNs occurs as a result of specific interactions between CBN structural conformation and cellular characteristics.

KW - Carbon nanoparticles

KW - Multivariate analysis

KW - Nanotoxicity

KW - Spectroscopy

KW - Synchrotron radiation

U2 - 10.1016/j.envint.2012.09.009

DO - 10.1016/j.envint.2012.09.009

M3 - Journal article

VL - 50

SP - 56

EP - 65

JO - Environment International

JF - Environment International

SN - 0160-4120

ER -