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Meta-analysis of ordinal outcomes using individual patient data.

Research output: Contribution to journalJournal article

Published

Journal publication date15/08/2001
JournalStatistics in Medicine
Journal number15
Volume20
Number of pages18
Pages2243-2260
Original languageEnglish

Abstract

Meta-analyses are being undertaken in an increasing diversity of diseases and conditions, some of which involve outcomes measured on an ordered categorical scale. We consider methodology for undertaking a meta-analysis on individual patient data for an ordinal response. The approach is based on the proportional odds model, in which the treatment effect is represented by the log-odds ratio. A general framework is proposed for fixed and random effect models. Tests of the validity of the various assumptions made in the meta-analysis models, such as a global test of the assumption of proportional odds between treatments, are presented. The combination of studies with different definitions or numbers of response categories is discussed. The methods are illustrated on two data sets, in a classical framework using SAS and MLn and in a Bayesian framework using BUGS. The relative merits of the three software packages for such meta-analyses are discussed. Copyright © 2001 John Wiley & Sons, Ltd.

Bibliographic note

This book consists of twelve chapters covering 305 pages. Chapters 1 and 2 are introductory; providing a rationale for meta-analysis and the key concepts and terminology. Chapters 3 and 4 provide a general framework for meta-analysis based on study estimates of treatment difference and their variances, extending the approach previously published by the author in Statistics in Medicine. Chapters 5 and 9-12 contain mainly original research by the author covering the topics of meta-analysis using individual patient data, dealing with non-standard sets of data, inclusion of trials with different designs, a Bayesian approach to meta-analysis and sequential methods for meta-analysis. The author has published 5 papers based on the work described in these chapters in journals such as Statistics in Medicine. There is ongoing research based on the contents of Chapter 12. Chapters 6-8 on dealing with heterogeneity, presentation and interpretation of results and selection bias mainly present methods which have appeared in the literature by other authors. RAE_import_type : Journal article RAE_uoa_type : Statistics and Operational Research