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Metabolic signatures of human Alzheimer's disease (AD): H-1 NMR analysis of the polar metabolome of post-mortem brain tissue

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Metabolic signatures of human Alzheimer's disease (AD): H-1 NMR analysis of the polar metabolome of post-mortem brain tissue. / Graham, Stewart F.; Holscher, Christian; Green, Brian D.
In: Metabolomics, Vol. 10, No. 4, 08.2014, p. 744-753.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Graham, SF, Holscher, C & Green, BD 2014, 'Metabolic signatures of human Alzheimer's disease (AD): H-1 NMR analysis of the polar metabolome of post-mortem brain tissue', Metabolomics, vol. 10, no. 4, pp. 744-753. https://doi.org/10.1007/s11306-013-0610-1

APA

Graham, S. F., Holscher, C., & Green, B. D. (2014). Metabolic signatures of human Alzheimer's disease (AD): H-1 NMR analysis of the polar metabolome of post-mortem brain tissue. Metabolomics, 10(4), 744-753. https://doi.org/10.1007/s11306-013-0610-1

Vancouver

Graham SF, Holscher C, Green BD. Metabolic signatures of human Alzheimer's disease (AD): H-1 NMR analysis of the polar metabolome of post-mortem brain tissue. Metabolomics. 2014 Aug;10(4):744-753. doi: 10.1007/s11306-013-0610-1

Author

Graham, Stewart F. ; Holscher, Christian ; Green, Brian D. / Metabolic signatures of human Alzheimer's disease (AD) : H-1 NMR analysis of the polar metabolome of post-mortem brain tissue. In: Metabolomics. 2014 ; Vol. 10, No. 4. pp. 744-753.

Bibtex

@article{d70ed72f6a3e42f79645c49fe3781a99,
title = "Metabolic signatures of human Alzheimer's disease (AD): H-1 NMR analysis of the polar metabolome of post-mortem brain tissue",
abstract = "Brain tissue from so-called Alzheimer's disease (AD) mouse models has previously been examined using H-1 NMR-metabolomics, but comparable information concerning human AD is negligible. Since no animal model recapitulates all the features of human AD we undertook the first H-1 NMR-metabolomics investigation of human AD brain tissue. Human post-mortem tissue from 15 AD subjects and 15 age-matched controls was prepared for analysis through a series of lyophilised, milling, extraction and randomisation steps and samples were analysed using H-1 NMR. Using partial least squares discriminant analysis, a model was built using data obtained from brain extracts. Analysis of brain extracts led to the elucidation of 24 metabolites. Significant elevations in brain alanine (15.4 %) and taurine (18.9 %) were observed in AD patients (p",
keywords = "Alzheimer's disease, Human, Clinical, Brain, Metabolomics, NMR, TAURINE, NEUROTRANSMISSION, METABOANALYST, SERVER",
author = "Graham, {Stewart F.} and Christian Holscher and Green, {Brian D.}",
year = "2014",
month = aug,
doi = "10.1007/s11306-013-0610-1",
language = "English",
volume = "10",
pages = "744--753",
journal = "Metabolomics",
issn = "1573-3882",
publisher = "Springer New York",
number = "4",

}

RIS

TY - JOUR

T1 - Metabolic signatures of human Alzheimer's disease (AD)

T2 - H-1 NMR analysis of the polar metabolome of post-mortem brain tissue

AU - Graham, Stewart F.

AU - Holscher, Christian

AU - Green, Brian D.

PY - 2014/8

Y1 - 2014/8

N2 - Brain tissue from so-called Alzheimer's disease (AD) mouse models has previously been examined using H-1 NMR-metabolomics, but comparable information concerning human AD is negligible. Since no animal model recapitulates all the features of human AD we undertook the first H-1 NMR-metabolomics investigation of human AD brain tissue. Human post-mortem tissue from 15 AD subjects and 15 age-matched controls was prepared for analysis through a series of lyophilised, milling, extraction and randomisation steps and samples were analysed using H-1 NMR. Using partial least squares discriminant analysis, a model was built using data obtained from brain extracts. Analysis of brain extracts led to the elucidation of 24 metabolites. Significant elevations in brain alanine (15.4 %) and taurine (18.9 %) were observed in AD patients (p

AB - Brain tissue from so-called Alzheimer's disease (AD) mouse models has previously been examined using H-1 NMR-metabolomics, but comparable information concerning human AD is negligible. Since no animal model recapitulates all the features of human AD we undertook the first H-1 NMR-metabolomics investigation of human AD brain tissue. Human post-mortem tissue from 15 AD subjects and 15 age-matched controls was prepared for analysis through a series of lyophilised, milling, extraction and randomisation steps and samples were analysed using H-1 NMR. Using partial least squares discriminant analysis, a model was built using data obtained from brain extracts. Analysis of brain extracts led to the elucidation of 24 metabolites. Significant elevations in brain alanine (15.4 %) and taurine (18.9 %) were observed in AD patients (p

KW - Alzheimer's disease

KW - Human

KW - Clinical

KW - Brain

KW - Metabolomics

KW - NMR

KW - TAURINE

KW - NEUROTRANSMISSION

KW - METABOANALYST

KW - SERVER

U2 - 10.1007/s11306-013-0610-1

DO - 10.1007/s11306-013-0610-1

M3 - Journal article

VL - 10

SP - 744

EP - 753

JO - Metabolomics

JF - Metabolomics

SN - 1573-3882

IS - 4

ER -