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    Rights statement: This is the author’s version of a work that was accepted for publication in Maturitas. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Maturitas, 83, 2016 DOI: 10.1016/j.maturitas.2015.10.008

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Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA)

Research output: Contribution to journalJournal article

Published
  • J Apostolo
  • Carol Ann Holland
  • Matthew O'Connell
  • Joanne Feeney
  • Rafael Tabares-Seisdedos
  • George Tadros
  • Elzbieta Campos
  • Nadine Santos
  • Deirdre Robertson
  • Maura Marcucci
  • Isabel Varela
  • Benedicto Crespo-Facorro
  • Eduard Vieta
  • Esperanza Navarro
  • Gabriel Selva-Vera
  • Vicent Balanza-Martinez
  • Antonio Cano
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<mark>Journal publication date</mark>01/2016
<mark>Journal</mark>Maturitas
Volume83
Number of pages11
Pages (from-to)83-93
Publication statusPublished
Original languageEnglish

Abstract

ABSTRACT
Introduction: Mild cognitive impairment (MCI) is a term used to describe a level of decline in cognition which is seen as an intermediate stage between normal ageing and dementia, and which many consider to be a prodromal stage of neurodegeneration that may become dementia. That is, it is perceived as a high risk level of cognitive change. The increasing burden of dementia in our society, but also our increasing understanding of its risk factors and potential interventions, require diligent management of MCI in order to find strategies that produce effective prevention of dementia.
Aim: To update knowledge regarding mild cognitive impairment, and to bring together and appraise evidence about the main features of clinical interest: definitions, prevalence and stability, risk factors, screening, and management and intervention.
Methods: Literature review and consensus of expert opinion.
Results and conclusion: MCI describes a level of impairment in which deteriorating cognitive functions still allow for reasonable independent living, including some compensatory strategies. While there is evidence for some early risk factors, there is still a need to more precisely delineate and distinguish early manifestations of frank dementia from cognitive impairment that is less likely to progress to dementia, and furthermore to develop improved prospective evidence for positive response to intervention. An important limitation derives from the scarcity of studies that take MCI as an endpoint. Strategies for effective management suffer from the same limitation, since most studies have focused on dementia. Behavioural changes may represent the most cost-effective approach.
Key words: cognition; mild cognitive decline; position statement; cognitive frailty.

Bibliographic note

This is the author’s version of a work that was accepted for publication in Maturitas. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Maturitas, 83, 2016 DOI: 10.1016/j.maturitas.2015.10.008