Rights statement: This is the author’s version of a work that was accepted for publication in Maturitas. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Maturitas, 83, 2016 DOI: 10.1016/j.maturitas.2015.10.008
Accepted author manuscript, 433 KB, PDF document
Available under license: CC BY-NC-ND
Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Mild cognitive decline. A position statement of the Cognitive Decline Group of the European Innovation Partnership for Active and Healthy Ageing (EIPAHA)
AU - Apostolo, J
AU - Holland, Carol Ann
AU - O'Connell, Matthew
AU - Feeney, Joanne
AU - Tabares-Seisdedos, Rafael
AU - Tadros, George
AU - Campos, Elzbieta
AU - Santos, Nadine
AU - Robertson, Deirdre
AU - Marcucci, Maura
AU - Varela, Isabel
AU - Crespo-Facorro, Benedicto
AU - Vieta, Eduard
AU - Navarro, Esperanza
AU - Selva-Vera, Gabriel
AU - Balanza-Martinez, Vicent
AU - Cano, Antonio
N1 - This is the author’s version of a work that was accepted for publication in Maturitas. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Maturitas, 83, 2016 DOI: 10.1016/j.maturitas.2015.10.008
PY - 2016/1
Y1 - 2016/1
N2 - ABSTRACTIntroduction: Mild cognitive impairment (MCI) is a term used to describe a level of decline in cognition which is seen as an intermediate stage between normal ageing and dementia, and which many consider to be a prodromal stage of neurodegeneration that may become dementia. That is, it is perceived as a high risk level of cognitive change. The increasing burden of dementia in our society, but also our increasing understanding of its risk factors and potential interventions, require diligent management of MCI in order to find strategies that produce effective prevention of dementia. Aim: To update knowledge regarding mild cognitive impairment, and to bring together and appraise evidence about the main features of clinical interest: definitions, prevalence and stability, risk factors, screening, and management and intervention.Methods: Literature review and consensus of expert opinion. Results and conclusion: MCI describes a level of impairment in which deteriorating cognitive functions still allow for reasonable independent living, including some compensatory strategies. While there is evidence for some early risk factors, there is still a need to more precisely delineate and distinguish early manifestations of frank dementia from cognitive impairment that is less likely to progress to dementia, and furthermore to develop improved prospective evidence for positive response to intervention. An important limitation derives from the scarcity of studies that take MCI as an endpoint. Strategies for effective management suffer from the same limitation, since most studies have focused on dementia. Behavioural changes may represent the most cost-effective approach.Key words: cognition; mild cognitive decline; position statement; cognitive frailty.
AB - ABSTRACTIntroduction: Mild cognitive impairment (MCI) is a term used to describe a level of decline in cognition which is seen as an intermediate stage between normal ageing and dementia, and which many consider to be a prodromal stage of neurodegeneration that may become dementia. That is, it is perceived as a high risk level of cognitive change. The increasing burden of dementia in our society, but also our increasing understanding of its risk factors and potential interventions, require diligent management of MCI in order to find strategies that produce effective prevention of dementia. Aim: To update knowledge regarding mild cognitive impairment, and to bring together and appraise evidence about the main features of clinical interest: definitions, prevalence and stability, risk factors, screening, and management and intervention.Methods: Literature review and consensus of expert opinion. Results and conclusion: MCI describes a level of impairment in which deteriorating cognitive functions still allow for reasonable independent living, including some compensatory strategies. While there is evidence for some early risk factors, there is still a need to more precisely delineate and distinguish early manifestations of frank dementia from cognitive impairment that is less likely to progress to dementia, and furthermore to develop improved prospective evidence for positive response to intervention. An important limitation derives from the scarcity of studies that take MCI as an endpoint. Strategies for effective management suffer from the same limitation, since most studies have focused on dementia. Behavioural changes may represent the most cost-effective approach.Key words: cognition; mild cognitive decline; position statement; cognitive frailty.
KW - Cognition
KW - Mild cognitive decline
KW - Position statement
KW - Cognitive frailty
U2 - 10.1016/j.maturitas.2015.10.008
DO - 10.1016/j.maturitas.2015.10.008
M3 - Journal article
VL - 83
SP - 83
EP - 93
JO - Maturitas
JF - Maturitas
ER -