Rights statement: This is the author’s version of a work that was accepted for publication in Mitochondrion. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Mitochondrion, 49, 2019 DOI: 10.1016/j.mito.2019.06.009
Accepted author manuscript, 461 KB, PDF document
Available under license: CC BY-NC-ND
Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Mitonuclear gene X environment effects on lifespan and health
T2 - How common, how big?
AU - Drummond, Emma
AU - Short, Emma
AU - Clancy, David
N1 - This is the author’s version of a work that was accepted for publication in Mitochondrion. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Mitochondrion, 49, 2019 DOI: 10.1016/j.mito.2019.06.009
PY - 2019/11/1
Y1 - 2019/11/1
N2 - Mitochondrial genetic variation can have profound effects on fitness, and the mitotype must interact with both the nuclear genes and the environment. We used Drosophila to investigate the extent to which mitotype effects on lifespan and activity are modulated by nucleotype and environmental variation. When nucleotype is varied, mitochondrial effects on lifespan persisted but were relatively small, and still male biased. Varying food as well, mitotype had substantial effects on male climbing speed, modifiable by nucleotype but less so by diet. Finally, mitotype affected fly lifespan much more in a cage environment compared with a vial, also modifiable by nucleotype and diet. The cage may represent a stressful environment. Mitochondrial genotype may affect fitness much more in conditions of stress, which may have implications for human health.
AB - Mitochondrial genetic variation can have profound effects on fitness, and the mitotype must interact with both the nuclear genes and the environment. We used Drosophila to investigate the extent to which mitotype effects on lifespan and activity are modulated by nucleotype and environmental variation. When nucleotype is varied, mitochondrial effects on lifespan persisted but were relatively small, and still male biased. Varying food as well, mitotype had substantial effects on male climbing speed, modifiable by nucleotype but less so by diet. Finally, mitotype affected fly lifespan much more in a cage environment compared with a vial, also modifiable by nucleotype and diet. The cage may represent a stressful environment. Mitochondrial genotype may affect fitness much more in conditions of stress, which may have implications for human health.
KW - Aging
KW - Drosophila
KW - Epistasis
KW - GxE interaction
KW - Lifespan
KW - Mitonuclear
KW - Stress
KW - adult
KW - aging
KW - article
KW - climbing
KW - diet
KW - epistasis
KW - genotype
KW - human
KW - lifespan
KW - male
KW - mitochondrion
KW - mitotype
KW - nonhuman
KW - stress
KW - velocity
U2 - 10.1016/j.mito.2019.06.009
DO - 10.1016/j.mito.2019.06.009
M3 - Journal article
VL - 49
SP - 12
EP - 18
JO - Mitochondrion
JF - Mitochondrion
SN - 1567-7249
ER -