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    Rights statement: This is the author’s version of a work that was accepted for publication in Mitochondrion. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Mitochondrion, 49, 2019 DOI: 10.1016/j.mito.2019.06.009

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Mitonuclear gene X environment effects on lifespan and health: How common, how big?

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Mitonuclear gene X environment effects on lifespan and health : How common, how big? / Drummond, Emma; Short, Emma; Clancy, David.

In: Mitochondrion, Vol. 49, 01.11.2019, p. 12-18.

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@article{7476ee989d9949b3b10cf46b9b1162af,
title = "Mitonuclear gene X environment effects on lifespan and health: How common, how big?",
abstract = "Mitochondrial genetic variation can have profound effects on fitness, and the mitotype must interact with both the nuclear genes and the environment. We used Drosophila to investigate the extent to which mitotype effects on lifespan and activity are modulated by nucleotype and environmental variation. When nucleotype is varied, mitochondrial effects on lifespan persisted but were relatively small, and still male biased. Varying food as well, mitotype had substantial effects on male climbing speed, modifiable by nucleotype but less so by diet. Finally, mitotype affected fly lifespan much more in a cage environment compared with a vial, also modifiable by nucleotype and diet. The cage may represent a stressful environment. Mitochondrial genotype may affect fitness much more in conditions of stress, which may have implications for human health.",
keywords = "Aging, Drosophila, Epistasis, GxE interaction, Lifespan, Mitonuclear, Stress, adult, aging, article, climbing, diet, epistasis, genotype, human, lifespan, male, mitochondrion, mitotype, nonhuman, stress, velocity",
author = "Emma Drummond and Emma Short and David Clancy",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Mitochondrion. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Mitochondrion, 49, 2019 DOI: 10.1016/j.mito.2019.06.009",
year = "2019",
month = nov
day = "1",
doi = "10.1016/j.mito.2019.06.009",
language = "English",
volume = "49",
pages = "12--18",
journal = "Mitochondrion",
issn = "1567-7249",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Mitonuclear gene X environment effects on lifespan and health

T2 - How common, how big?

AU - Drummond, Emma

AU - Short, Emma

AU - Clancy, David

N1 - This is the author’s version of a work that was accepted for publication in Mitochondrion. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Mitochondrion, 49, 2019 DOI: 10.1016/j.mito.2019.06.009

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Mitochondrial genetic variation can have profound effects on fitness, and the mitotype must interact with both the nuclear genes and the environment. We used Drosophila to investigate the extent to which mitotype effects on lifespan and activity are modulated by nucleotype and environmental variation. When nucleotype is varied, mitochondrial effects on lifespan persisted but were relatively small, and still male biased. Varying food as well, mitotype had substantial effects on male climbing speed, modifiable by nucleotype but less so by diet. Finally, mitotype affected fly lifespan much more in a cage environment compared with a vial, also modifiable by nucleotype and diet. The cage may represent a stressful environment. Mitochondrial genotype may affect fitness much more in conditions of stress, which may have implications for human health.

AB - Mitochondrial genetic variation can have profound effects on fitness, and the mitotype must interact with both the nuclear genes and the environment. We used Drosophila to investigate the extent to which mitotype effects on lifespan and activity are modulated by nucleotype and environmental variation. When nucleotype is varied, mitochondrial effects on lifespan persisted but were relatively small, and still male biased. Varying food as well, mitotype had substantial effects on male climbing speed, modifiable by nucleotype but less so by diet. Finally, mitotype affected fly lifespan much more in a cage environment compared with a vial, also modifiable by nucleotype and diet. The cage may represent a stressful environment. Mitochondrial genotype may affect fitness much more in conditions of stress, which may have implications for human health.

KW - Aging

KW - Drosophila

KW - Epistasis

KW - GxE interaction

KW - Lifespan

KW - Mitonuclear

KW - Stress

KW - adult

KW - aging

KW - article

KW - climbing

KW - diet

KW - epistasis

KW - genotype

KW - human

KW - lifespan

KW - male

KW - mitochondrion

KW - mitotype

KW - nonhuman

KW - stress

KW - velocity

U2 - 10.1016/j.mito.2019.06.009

DO - 10.1016/j.mito.2019.06.009

M3 - Journal article

VL - 49

SP - 12

EP - 18

JO - Mitochondrion

JF - Mitochondrion

SN - 1567-7249

ER -