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Molecular epidemiology and genetic diversity of Campylobacter jejuni in ruminants

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Molecular epidemiology and genetic diversity of Campylobacter jejuni in ruminants. / Grove-White, D. H.; Leatherbarrow, A. J. H.; Cripps, P. J. et al.
In: Epidemiology and Infection, Vol. 139, No. 11, 11.2011, p. 1661-1671.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Grove-White, DH, Leatherbarrow, AJH, Cripps, PJ, Diggle, PJ & French, NP 2011, 'Molecular epidemiology and genetic diversity of Campylobacter jejuni in ruminants', Epidemiology and Infection, vol. 139, no. 11, pp. 1661-1671. https://doi.org/10.1017/S0950268810002736

APA

Grove-White, D. H., Leatherbarrow, A. J. H., Cripps, P. J., Diggle, P. J., & French, N. P. (2011). Molecular epidemiology and genetic diversity of Campylobacter jejuni in ruminants. Epidemiology and Infection, 139(11), 1661-1671. https://doi.org/10.1017/S0950268810002736

Vancouver

Grove-White DH, Leatherbarrow AJH, Cripps PJ, Diggle PJ, French NP. Molecular epidemiology and genetic diversity of Campylobacter jejuni in ruminants. Epidemiology and Infection. 2011 Nov;139(11):1661-1671. doi: 10.1017/S0950268810002736

Author

Grove-White, D. H. ; Leatherbarrow, A. J. H. ; Cripps, P. J. et al. / Molecular epidemiology and genetic diversity of Campylobacter jejuni in ruminants. In: Epidemiology and Infection. 2011 ; Vol. 139, No. 11. pp. 1661-1671.

Bibtex

@article{a9bf0eeeef0249f19f6d379cfc96b167,
title = "Molecular epidemiology and genetic diversity of Campylobacter jejuni in ruminants",
abstract = "Multi-locus sequence typing was performed on 1003 Campylobacter jejuni isolates collected in a 2-year longitudinal study of 15 dairy farms and four sheep farms in Lancashire, UK. There was considerable farm-level variation in occurrence and prevalence of clonal complexes (CC). Clonal complexes ST61, ST21, ST403 and ST45 were most prevalent in cattle while in sheep CC ST42, ST21, ST48 and ST52 were most prevalent. CC ST45, a complex previously shown to be more common in summer months in human cases, was more prevalent in summer in our ruminant samples. Gene flow analysis demonstrated a high level of genetic heterogeneity at the within-farm level. Sequence-type diversity was greater in cattle compared to sheep, in cattle at pasture vs. housed, and in isolates from farms on the Pennines compared to the Southern Fylde. Sequence-type diversity was greatest in isolates belonging to CC ST21, ST45 and ST206.",
keywords = "Campylobacter, cow, epidemiology, MLST, sheep, POPULATION-STRUCTURE, CHICKEN MEAT, DAIRY FARMS, COLI, ENGLAND, WALES, PCR, IDENTIFICATION, ANIMALS, DISEASE",
author = "Grove-White, {D. H.} and Leatherbarrow, {A. J. H.} and Cripps, {P. J.} and Diggle, {P. J.} and French, {N. P.}",
year = "2011",
month = nov,
doi = "10.1017/S0950268810002736",
language = "English",
volume = "139",
pages = "1661--1671",
journal = "Epidemiology and Infection",
issn = "0950-2688",
publisher = "Cambridge University Press",
number = "11",

}

RIS

TY - JOUR

T1 - Molecular epidemiology and genetic diversity of Campylobacter jejuni in ruminants

AU - Grove-White, D. H.

AU - Leatherbarrow, A. J. H.

AU - Cripps, P. J.

AU - Diggle, P. J.

AU - French, N. P.

PY - 2011/11

Y1 - 2011/11

N2 - Multi-locus sequence typing was performed on 1003 Campylobacter jejuni isolates collected in a 2-year longitudinal study of 15 dairy farms and four sheep farms in Lancashire, UK. There was considerable farm-level variation in occurrence and prevalence of clonal complexes (CC). Clonal complexes ST61, ST21, ST403 and ST45 were most prevalent in cattle while in sheep CC ST42, ST21, ST48 and ST52 were most prevalent. CC ST45, a complex previously shown to be more common in summer months in human cases, was more prevalent in summer in our ruminant samples. Gene flow analysis demonstrated a high level of genetic heterogeneity at the within-farm level. Sequence-type diversity was greater in cattle compared to sheep, in cattle at pasture vs. housed, and in isolates from farms on the Pennines compared to the Southern Fylde. Sequence-type diversity was greatest in isolates belonging to CC ST21, ST45 and ST206.

AB - Multi-locus sequence typing was performed on 1003 Campylobacter jejuni isolates collected in a 2-year longitudinal study of 15 dairy farms and four sheep farms in Lancashire, UK. There was considerable farm-level variation in occurrence and prevalence of clonal complexes (CC). Clonal complexes ST61, ST21, ST403 and ST45 were most prevalent in cattle while in sheep CC ST42, ST21, ST48 and ST52 were most prevalent. CC ST45, a complex previously shown to be more common in summer months in human cases, was more prevalent in summer in our ruminant samples. Gene flow analysis demonstrated a high level of genetic heterogeneity at the within-farm level. Sequence-type diversity was greater in cattle compared to sheep, in cattle at pasture vs. housed, and in isolates from farms on the Pennines compared to the Southern Fylde. Sequence-type diversity was greatest in isolates belonging to CC ST21, ST45 and ST206.

KW - Campylobacter

KW - cow

KW - epidemiology

KW - MLST

KW - sheep

KW - POPULATION-STRUCTURE

KW - CHICKEN MEAT

KW - DAIRY FARMS

KW - COLI

KW - ENGLAND

KW - WALES

KW - PCR

KW - IDENTIFICATION

KW - ANIMALS

KW - DISEASE

U2 - 10.1017/S0950268810002736

DO - 10.1017/S0950268810002736

M3 - Journal article

VL - 139

SP - 1661

EP - 1671

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 11

ER -