The contextual-based multi-source time-series remote sensing and proposed Comprehensive Heritage Area Threats Index (CHATI) index are used to analyze the spatiotemporal land use/land cover (LULC) and threats to the Mount Wutai World Heritage Area. The results show disturbances, such as forest coverage, vegetation conditions, mining area, and built-up area, in the research area changed dramatically. According to the CHATI, although different disturbances have positive or negative influences on environment, as an integrated system it kept stable from 1987 to 2018. Finally, this research uses linear regression and the F-test to mark the remarkable spatial-temporal variation. In consequence, the threats on Mount Wutai be addressed from the macro level and the micro level. Although there still have some drawbacks, the effectiveness of threat identification has been tested using field validation and the results are a reliable tool to raise the public awareness of WHA protection and governance.