Monoclonal antibodies raised against a subsequence of senile plaque core protein react with plaque cores, plaque periphery and cerebrovascular amyloid in Alzheimer's disease

Biomedical and Life Sciences

Keywords

Alzheimer Disease, Amyloid, Antibodies, Monoclonal, Blood Vessels, Cerebral Cortex, Humans, Nerve Tissue Proteins, Neurofibrils

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Monoclonal antibodies raised against a subsequence of senile plaque core protein react with plaque cores, plaque periphery and cerebrovascular amyloid in Alzheimer's disease. / Allsop, D; Landon, M; Kidd, M et al.
In: Neuroscience Letters, Vol. 68, No. 2, 1986, p. 252-6.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{c4b28f54eec5480aa2eeac4f66bb2d98,

title = "Monoclonal antibodies raised against a subsequence of senile plaque core protein react with plaque cores, plaque periphery and cerebrovascular amyloid in Alzheimer's disease",

abstract = "Four monoclonal antibodies (1D2/1/2, 1G10/2/3, 3B6/1/1, 4D12/2/6) were raised against a synthetic peptide consisting of residues 8-17 of a protein reported to be common to senile plaque cores, cerebrovascular amyloid and neurofibrillary tangles in Alzheimer's disease. In an immunoperoxidase study of Alzheimer brain tissue, these antibodies stained plaque and vascular amyloid but not tangles, suggesting that the polypeptide chain in the region of residues 8-17 is exposed in the former two but, if present, inaccessible in the latter. In addition, staining of granular material in the plaque periphery was observed. These antibodies will be useful tools for future work on the origin of this protein.",

keywords = "Alzheimer Disease, Amyloid, Antibodies, Monoclonal, Blood Vessels, Cerebral Cortex, Humans, Nerve Tissue Proteins, Neurofibrils",

author = "D Allsop and M Landon and M Kidd and Lowe, {J S} and Reynolds, {G P} and A Gardner",

year = "1986",

language = "English",

volume = "68",

pages = "252--6",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "ELSEVIER IRELAND LTD",

number = "2",

}

RIS

TY - JOUR

T1 - Monoclonal antibodies raised against a subsequence of senile plaque core protein react with plaque cores, plaque periphery and cerebrovascular amyloid in Alzheimer's disease

AU - Allsop, D

AU - Landon, M

AU - Kidd, M

AU - Lowe, J S

AU - Reynolds, G P

AU - Gardner, A

PY - 1986

Y1 - 1986

N2 - Four monoclonal antibodies (1D2/1/2, 1G10/2/3, 3B6/1/1, 4D12/2/6) were raised against a synthetic peptide consisting of residues 8-17 of a protein reported to be common to senile plaque cores, cerebrovascular amyloid and neurofibrillary tangles in Alzheimer's disease. In an immunoperoxidase study of Alzheimer brain tissue, these antibodies stained plaque and vascular amyloid but not tangles, suggesting that the polypeptide chain in the region of residues 8-17 is exposed in the former two but, if present, inaccessible in the latter. In addition, staining of granular material in the plaque periphery was observed. These antibodies will be useful tools for future work on the origin of this protein.

AB - Four monoclonal antibodies (1D2/1/2, 1G10/2/3, 3B6/1/1, 4D12/2/6) were raised against a synthetic peptide consisting of residues 8-17 of a protein reported to be common to senile plaque cores, cerebrovascular amyloid and neurofibrillary tangles in Alzheimer's disease. In an immunoperoxidase study of Alzheimer brain tissue, these antibodies stained plaque and vascular amyloid but not tangles, suggesting that the polypeptide chain in the region of residues 8-17 is exposed in the former two but, if present, inaccessible in the latter. In addition, staining of granular material in the plaque periphery was observed. These antibodies will be useful tools for future work on the origin of this protein.

KW - Alzheimer Disease

KW - Amyloid

KW - Antibodies, Monoclonal

KW - Blood Vessels

KW - Cerebral Cortex

KW - Humans

KW - Nerve Tissue Proteins

KW - Neurofibrils

M3 - Journal article

C2 - 3748453

VL - 68

SP - 252

EP - 256

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2

ER -

Research

Keywords