TY - JOUR

T1 - Multidimensional longitudinal data: estimating a treatment effect from continuous, discrete, or time to event response variables.

AU - Gray, S. M.

AU - Brookmeyer, R.

PY - 2000

Y1 - 2000

N2 - Multidimensional data arise when a number of different response variables are required to measure the outcome of interest. Examples of such outcomes include quality of life, cognitive ability, and health status. The goal of this article is to develop a methodology to estimate a treatment effect from multidimensional data that have been collected longitudinally using continuous, discrete, or time-to-event responses or a mixture of these types of responses. A transformation of the time scale that does not depend on the units of the response variables is used to capture the effect of treatment. This allows information about the treatment effect to be combined across response variables of different types. The model is specified using a pair of regression models for the first two moments, and generalized estimating equations are used for parameter estimation. The methodology is applied to quality-of-life data from an AIDS clinical trial and health status data from an Alzheimer's disease study.

AB - Multidimensional data arise when a number of different response variables are required to measure the outcome of interest. Examples of such outcomes include quality of life, cognitive ability, and health status. The goal of this article is to develop a methodology to estimate a treatment effect from multidimensional data that have been collected longitudinally using continuous, discrete, or time-to-event responses or a mixture of these types of responses. A transformation of the time scale that does not depend on the units of the response variables is used to capture the effect of treatment. This allows information about the treatment effect to be combined across response variables of different types. The model is specified using a pair of regression models for the first two moments, and generalized estimating equations are used for parameter estimation. The methodology is applied to quality-of-life data from an AIDS clinical trial and health status data from an Alzheimer's disease study.

KW - Acceleration

KW - Alzheimer's disease

KW - Generalized estimating equations

KW - Longitudinal data analysis

KW - Multidimensional data

KW - Quality of life.

M3 - Journal article

VL - 95

SP - 396

EP - 406

JO - Journal of the American Statistical Association

JF - Journal of the American Statistical Association

SN - 1537-274X

IS - 450

ER -