Multimodal Radio- (PET / SPECT) and Fluorescence Imaging Agents Based on Metallo-Radioisotopes: Current Applications and Prospects for Development of New Agents

Chemistry

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https://doi.org/10.1039/C0DT01398F
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Multimodal Radio- (PET / SPECT) and Fluorescence Imaging Agents Based on Metallo-Radioisotopes: Current Applications and Prospects for Development of New Agents. / Thorp-Greenwood, Flora L. ; Coogan, Michael.
In: Dalton Transactions, Vol. 40, No. 23, 2011, p. 6129-6143.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{9f48bb0419234c57b14612da96d06b23,

title = "Multimodal Radio- (PET / SPECT) and Fluorescence Imaging Agents Based on Metallo-Radioisotopes: Current Applications and Prospects for Development of New Agents",

abstract = "This perspective focuses on complexes of radioactive metal ions applied in multimodal radio- and optical imaging. The application of metal ions in radioimaging techniques such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) has advantages over lighter nuclei in terms of half-life, but there are particular issues related to their speciation (particularly leaching from complexes) and with the combination of certain ions with fluorescent systems. The basic coordination chemistry of the ions involved and issues relating to biological conditions and their compatibility with optical imaging techniques are reviewed, the current literature presented in context, and the prospect of exploiting the intrinsic luminescence of certain metal–ligand complexes is discussed.",

author = "Thorp-Greenwood, {Flora L.} and Michael Coogan",

year = "2011",

doi = "10.1039/C0DT01398F",

language = "English",

volume = "40",

pages = "6129--6143",

journal = "Dalton Transactions",

issn = "1477-9234",

publisher = "Royal Society of Chemistry",

number = "23",

}

RIS

TY - JOUR

T1 - Multimodal Radio- (PET / SPECT) and Fluorescence Imaging Agents Based on Metallo-Radioisotopes: Current Applications and Prospects for Development of New Agents

AU - Thorp-Greenwood, Flora L.

AU - Coogan, Michael

PY - 2011

Y1 - 2011

N2 - This perspective focuses on complexes of radioactive metal ions applied in multimodal radio- and optical imaging. The application of metal ions in radioimaging techniques such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) has advantages over lighter nuclei in terms of half-life, but there are particular issues related to their speciation (particularly leaching from complexes) and with the combination of certain ions with fluorescent systems. The basic coordination chemistry of the ions involved and issues relating to biological conditions and their compatibility with optical imaging techniques are reviewed, the current literature presented in context, and the prospect of exploiting the intrinsic luminescence of certain metal–ligand complexes is discussed.

AB - This perspective focuses on complexes of radioactive metal ions applied in multimodal radio- and optical imaging. The application of metal ions in radioimaging techniques such as Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) has advantages over lighter nuclei in terms of half-life, but there are particular issues related to their speciation (particularly leaching from complexes) and with the combination of certain ions with fluorescent systems. The basic coordination chemistry of the ions involved and issues relating to biological conditions and their compatibility with optical imaging techniques are reviewed, the current literature presented in context, and the prospect of exploiting the intrinsic luminescence of certain metal–ligand complexes is discussed.

U2 - 10.1039/C0DT01398F

DO - 10.1039/C0DT01398F

M3 - Journal article

VL - 40

SP - 6129

EP - 6143

JO - Dalton Transactions

JF - Dalton Transactions

SN - 1477-9234

IS - 23

ER -

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