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Nanocrystal recovery by use of carrier particles

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<mark>Journal publication date</mark>03/2014
<mark>Journal</mark>Crystal Growth and Design
Issue number3
Volume14
Number of pages7
Pages (from-to)1003-1009
Publication statusPublished
Original languageEnglish

Abstract

Aqueous dispersions of nanoparticles (nanosuspensions) of poorly soluble drugs are an effective option for addressing issues of low and erratic bioavailability. They are, however, not attractive as dosage forms due to their predisposition to physical and chemical instability. Here we describe an effective method for isolating nanocrystals in solid form from a suspension, which opens up the possibility of formulating nanocrystals in solid dosage forms such as tablets. The method involves the use of carrier particles to adsorb and recover nanocrystals from a liquid suspension. The method is illustrated by using carrier particles of dibasic calcium phosphate to recover nanocrystals of ibuprofen and glibenclamide produced by both size reduction and crystallization. Respective recoveries of the nanocrystals were in excess of 90%. Powders of carrier-nanocrystal particles yielded dissolution rates similar to those of the native nanocrystals and substantially faster than marketed tablets and micronized suspensions of the drugs, confirming that the high surface area of the nanocrystals is retained during the adsorption process.