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Nanocrystal recovery by use of carrier particles

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Nanocrystal recovery by use of carrier particles. / Khan, Shahzeb; de Matas, Marcel; Plakkot, Smitha; Anwar, Jamshed.

In: Crystal Growth and Design, Vol. 14, No. 3, 03.2014, p. 1003-1009.

Research output: Contribution to journalJournal article

Harvard

Khan, S, de Matas, M, Plakkot, S & Anwar, J 2014, 'Nanocrystal recovery by use of carrier particles', Crystal Growth and Design, vol. 14, no. 3, pp. 1003-1009. https://doi.org/10.1021/cg401432m

APA

Khan, S., de Matas, M., Plakkot, S., & Anwar, J. (2014). Nanocrystal recovery by use of carrier particles. Crystal Growth and Design, 14(3), 1003-1009. https://doi.org/10.1021/cg401432m

Vancouver

Khan S, de Matas M, Plakkot S, Anwar J. Nanocrystal recovery by use of carrier particles. Crystal Growth and Design. 2014 Mar;14(3):1003-1009. https://doi.org/10.1021/cg401432m

Author

Khan, Shahzeb ; de Matas, Marcel ; Plakkot, Smitha ; Anwar, Jamshed. / Nanocrystal recovery by use of carrier particles. In: Crystal Growth and Design. 2014 ; Vol. 14, No. 3. pp. 1003-1009.

Bibtex

@article{0d556092b2c440adb2c78b55bb6daaee,
title = "Nanocrystal recovery by use of carrier particles",
abstract = "Aqueous dispersions of nanoparticles (nanosuspensions) of poorly soluble drugs are an effective option for addressing issues of low and erratic bioavailability. They are, however, not attractive as dosage forms due to their predisposition to physical and chemical instability. Here we describe an effective method for isolating nanocrystals in solid form from a suspension, which opens up the possibility of formulating nanocrystals in solid dosage forms such as tablets. The method involves the use of carrier particles to adsorb and recover nanocrystals from a liquid suspension. The method is illustrated by using carrier particles of dibasic calcium phosphate to recover nanocrystals of ibuprofen and glibenclamide produced by both size reduction and crystallization. Respective recoveries of the nanocrystals were in excess of 90%. Powders of carrier-nanocrystal particles yielded dissolution rates similar to those of the native nanocrystals and substantially faster than marketed tablets and micronized suspensions of the drugs, confirming that the high surface area of the nanocrystals is retained during the adsorption process.",
keywords = "DRY POWDER INHALERS, DRUG-DELIVERY, NANOPARTICLES, FORMULATIONS, INHALATION, FORCES, NANOSUSPENSIONS, DISSOLUTION, MORPHOLOGY, CONVERSION",
author = "Shahzeb Khan and {de Matas}, Marcel and Smitha Plakkot and Jamshed Anwar",
year = "2014",
month = mar
doi = "10.1021/cg401432m",
language = "English",
volume = "14",
pages = "1003--1009",
journal = "Crystal Growth and Design",
issn = "1528-7483",
publisher = "American Chemical Society",
number = "3",

}

RIS

TY - JOUR

T1 - Nanocrystal recovery by use of carrier particles

AU - Khan, Shahzeb

AU - de Matas, Marcel

AU - Plakkot, Smitha

AU - Anwar, Jamshed

PY - 2014/3

Y1 - 2014/3

N2 - Aqueous dispersions of nanoparticles (nanosuspensions) of poorly soluble drugs are an effective option for addressing issues of low and erratic bioavailability. They are, however, not attractive as dosage forms due to their predisposition to physical and chemical instability. Here we describe an effective method for isolating nanocrystals in solid form from a suspension, which opens up the possibility of formulating nanocrystals in solid dosage forms such as tablets. The method involves the use of carrier particles to adsorb and recover nanocrystals from a liquid suspension. The method is illustrated by using carrier particles of dibasic calcium phosphate to recover nanocrystals of ibuprofen and glibenclamide produced by both size reduction and crystallization. Respective recoveries of the nanocrystals were in excess of 90%. Powders of carrier-nanocrystal particles yielded dissolution rates similar to those of the native nanocrystals and substantially faster than marketed tablets and micronized suspensions of the drugs, confirming that the high surface area of the nanocrystals is retained during the adsorption process.

AB - Aqueous dispersions of nanoparticles (nanosuspensions) of poorly soluble drugs are an effective option for addressing issues of low and erratic bioavailability. They are, however, not attractive as dosage forms due to their predisposition to physical and chemical instability. Here we describe an effective method for isolating nanocrystals in solid form from a suspension, which opens up the possibility of formulating nanocrystals in solid dosage forms such as tablets. The method involves the use of carrier particles to adsorb and recover nanocrystals from a liquid suspension. The method is illustrated by using carrier particles of dibasic calcium phosphate to recover nanocrystals of ibuprofen and glibenclamide produced by both size reduction and crystallization. Respective recoveries of the nanocrystals were in excess of 90%. Powders of carrier-nanocrystal particles yielded dissolution rates similar to those of the native nanocrystals and substantially faster than marketed tablets and micronized suspensions of the drugs, confirming that the high surface area of the nanocrystals is retained during the adsorption process.

KW - DRY POWDER INHALERS

KW - DRUG-DELIVERY

KW - NANOPARTICLES

KW - FORMULATIONS

KW - INHALATION

KW - FORCES

KW - NANOSUSPENSIONS

KW - DISSOLUTION

KW - MORPHOLOGY

KW - CONVERSION

U2 - 10.1021/cg401432m

DO - 10.1021/cg401432m

M3 - Journal article

VL - 14

SP - 1003

EP - 1009

JO - Crystal Growth and Design

JF - Crystal Growth and Design

SN - 1528-7483

IS - 3

ER -