12,000

We have over 12,000 students, from over 100 countries, within one of the safest campuses in the UK

93%

93% of Lancaster students go into work or further study within six months of graduating

Home > Research > Publications & Outputs > Neuronal synchrony during anesthesia
View graph of relations

« Back

Neuronal synchrony during anesthesia: a thalamocortical model

Research output: Contribution to journalJournal article

Published

Journal publication date15/09/2008
JournalBiophysical Journal
Journal number6
Volume95
Number of pages6
Pages2722-2727
Original languageEnglish

Abstract

There is growing evidence in favor of the temporal-coding hypothesis that temporal correlation of neuronal discharges may serve to bind distributed neuronal activity into unique representations and, in particular, that theta (3.5–7.5 Hz) and delta (0.5 , 3.5 Hz) oscillations facilitate information coding. The theta- and delta-rhythms are shown to be involved in various sleep stages, and during anesthesia, they undergo changes with the depth of anesthesia. We introduce a thalamocortical model of interacting neuronal ensembles to describe phase relationships between theta- and delta-oscillations, especially during deep and light anesthesia. Asymmetric and long-range interactions among the thalamocortical neuronal oscillators are taken into account. The model results are compared with experimental observations. The delta- and theta-activities are found to be separately generated and are governed by the thalamus and cortex, respectively. Changes in the degree of intraensemble and interensemble synchrony imply that the neuronal ensembles inhibit information coding during deep anesthesia and facilitate it during light anesthesia.

Bibliographic note

Copyright (c) 2008 The Biophysical Society