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Neuronal synchrony during anesthesia: a thalamocortical model

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Neuronal synchrony during anesthesia: a thalamocortical model. / Sheeba, Jane H.; Stefanovska, Aneta; McClintock, Peter V. E.
In: Biophysical Journal, Vol. 95, No. 6, 15.09.2008, p. 2722-2727.

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Sheeba JH, Stefanovska A, McClintock PVE. Neuronal synchrony during anesthesia: a thalamocortical model. Biophysical Journal. 2008 Sept 15;95(6):2722-2727. doi: 10.1529/biophysj.108.134635

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Sheeba, Jane H. ; Stefanovska, Aneta ; McClintock, Peter V. E. / Neuronal synchrony during anesthesia : a thalamocortical model. In: Biophysical Journal. 2008 ; Vol. 95, No. 6. pp. 2722-2727.

Bibtex

@article{9313f958bb75488c9cae00c4f2c352e2,
title = "Neuronal synchrony during anesthesia: a thalamocortical model",
abstract = "There is growing evidence in favor of the temporal-coding hypothesis that temporal correlation of neuronal discharges may serve to bind distributed neuronal activity into unique representations and, in particular, that theta (3.5–7.5 Hz) and delta (0.5 , 3.5 Hz) oscillations facilitate information coding. The theta- and delta-rhythms are shown to be involved in various sleep stages, and during anesthesia, they undergo changes with the depth of anesthesia. We introduce a thalamocortical model of interacting neuronal ensembles to describe phase relationships between theta- and delta-oscillations, especially during deep and light anesthesia. Asymmetric and long-range interactions among the thalamocortical neuronal oscillators are taken into account. The model results are compared with experimental observations. The delta- and theta-activities are found to be separately generated and are governed by the thalamus and cortex, respectively. Changes in the degree of intraensemble and interensemble synchrony imply that the neuronal ensembles inhibit information coding during deep anesthesia and facilitate it during light anesthesia.",
author = "Sheeba, {Jane H.} and Aneta Stefanovska and McClintock, {Peter V. E.}",
note = "Copyright (c) 2008 The Biophysical Society",
year = "2008",
month = sep,
day = "15",
doi = "10.1529/biophysj.108.134635",
language = "English",
volume = "95",
pages = "2722--2727",
journal = "Biophysical Journal",
issn = "0006-3495",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Neuronal synchrony during anesthesia

T2 - a thalamocortical model

AU - Sheeba, Jane H.

AU - Stefanovska, Aneta

AU - McClintock, Peter V. E.

N1 - Copyright (c) 2008 The Biophysical Society

PY - 2008/9/15

Y1 - 2008/9/15

N2 - There is growing evidence in favor of the temporal-coding hypothesis that temporal correlation of neuronal discharges may serve to bind distributed neuronal activity into unique representations and, in particular, that theta (3.5–7.5 Hz) and delta (0.5 , 3.5 Hz) oscillations facilitate information coding. The theta- and delta-rhythms are shown to be involved in various sleep stages, and during anesthesia, they undergo changes with the depth of anesthesia. We introduce a thalamocortical model of interacting neuronal ensembles to describe phase relationships between theta- and delta-oscillations, especially during deep and light anesthesia. Asymmetric and long-range interactions among the thalamocortical neuronal oscillators are taken into account. The model results are compared with experimental observations. The delta- and theta-activities are found to be separately generated and are governed by the thalamus and cortex, respectively. Changes in the degree of intraensemble and interensemble synchrony imply that the neuronal ensembles inhibit information coding during deep anesthesia and facilitate it during light anesthesia.

AB - There is growing evidence in favor of the temporal-coding hypothesis that temporal correlation of neuronal discharges may serve to bind distributed neuronal activity into unique representations and, in particular, that theta (3.5–7.5 Hz) and delta (0.5 , 3.5 Hz) oscillations facilitate information coding. The theta- and delta-rhythms are shown to be involved in various sleep stages, and during anesthesia, they undergo changes with the depth of anesthesia. We introduce a thalamocortical model of interacting neuronal ensembles to describe phase relationships between theta- and delta-oscillations, especially during deep and light anesthesia. Asymmetric and long-range interactions among the thalamocortical neuronal oscillators are taken into account. The model results are compared with experimental observations. The delta- and theta-activities are found to be separately generated and are governed by the thalamus and cortex, respectively. Changes in the degree of intraensemble and interensemble synchrony imply that the neuronal ensembles inhibit information coding during deep anesthesia and facilitate it during light anesthesia.

U2 - 10.1529/biophysj.108.134635

DO - 10.1529/biophysj.108.134635

M3 - Journal article

VL - 95

SP - 2722

EP - 2727

JO - Biophysical Journal

JF - Biophysical Journal

SN - 0006-3495

IS - 6

ER -