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Neuroprotective effects of geniposide on Alzheimer's disease pathology

Research output: Contribution to journalJournal article

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<mark>Journal publication date</mark>08/2015
<mark>Journal</mark>Reviews in the Neurosciences
Issue number4
Volume26
Number of pages13
Pages (from-to)371-383
Publication statusPublished
Early online date16/04/15
Original languageEnglish

Abstract

A growing body of evidence has linked two of the most common aged-related diseases: type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD). It has led to the notion that drugs developed for the treatment of T2DM may be beneficial in modifying the pathophysiology of AD. As a receptor agonist of glucagon-like peptide-1 (GLP-1R), which is a newer drug class to treat T2DM, geniposide shows clear effects in inhibiting pathological processes underlying AD, such as promoting neurite outgrowth. In the present article, we review the possible molecular mechanisms of geniposide to protect the brain from pathologic damages underlying AD: reducing amyloid plaques, inhibiting τ phosphorylation, preventing memory impairment and loss of synapses, reducing oxidative stress and the chronic inflammatory response, and promoting neurite outgrowth via the GLP-1R signaling pathway. In summary, the Chinese herb geniposide shows great promise as a novel treatment for AD.

Bibliographic note

Date of Acceptance: 25/02/2015