Final published version
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
Research output: Contribution in Book/Report/Proceedings - With ISBN/ISSN › Chapter
}
TY - CHAP
T1 - Next generation techniques for biomedical imaging
AU - Richens, Joanna L.
AU - O'Shea, Paul
PY - 2014
Y1 - 2014
N2 - To understand fully an organism in health and disease we must assemble a genuinely comprehensive model of the organism, including metabolic profiles for both large and small molecules together with their interaction profiles. This chapter outlines how particular applications of imaging technologies are revolutionising such a 'systems' understanding of biology and medicine. The combination of such 'Omics' approaches (e.g. proteomics and genomics) with imaging science will lead to a much more comprehensive description of biological systems, allowing us to pose new questions about the nature of biology and offering new ways for the practice of medicine. Label-free approaches using plasmonic microscopy are described, and Alzheimer's disease is used as an exemplar of how disease diagnostics may be enhanced by application of such approaches and technologies. Some advances of conventional plasmonic imaging techniques, based on using localised plasmons, that seem likely to yield greater sensitivity and functionality are proposed. © 2014 Woodhead Publishing Limited All rights reserved.
AB - To understand fully an organism in health and disease we must assemble a genuinely comprehensive model of the organism, including metabolic profiles for both large and small molecules together with their interaction profiles. This chapter outlines how particular applications of imaging technologies are revolutionising such a 'systems' understanding of biology and medicine. The combination of such 'Omics' approaches (e.g. proteomics and genomics) with imaging science will lead to a much more comprehensive description of biological systems, allowing us to pose new questions about the nature of biology and offering new ways for the practice of medicine. Label-free approaches using plasmonic microscopy are described, and Alzheimer's disease is used as an exemplar of how disease diagnostics may be enhanced by application of such approaches and technologies. Some advances of conventional plasmonic imaging techniques, based on using localised plasmons, that seem likely to yield greater sensitivity and functionality are proposed. © 2014 Woodhead Publishing Limited All rights reserved.
KW - Alzheimer's disease
KW - Biomarker
KW - Metabolomics
KW - Molecular array
KW - Nanoparticles
KW - Plasmonics
KW - Proteomics
U2 - 10.1533/9780857097477.1.65
DO - 10.1533/9780857097477.1.65
M3 - Chapter
SN - 9780857091277
T3 - Biomedical Imaging: Applications and Advances
SP - 65
EP - 92
BT - Biomedical Imaging
A2 - Morris, Peter
PB - Elsevier Inc.
ER -