TY - JOUR

T1 - Notch Signalling as a Therapeutic Target in Cancer

AU - Martinas, Ioana

AU - Parkin, Edward Thomas

PY - 2016/10

Y1 - 2016/10

N2 - Notch signalling is a conserved developmental pathway involved, inter alia, in cell-fate decision, morphogenesis and tissue patterning. Extensive research has linked this pathways with a variety of malignancies, cancer stem cell renewal, induction of epithelial-to-mesenchymal transition and tumor angiogenesis. These data indicate that Notch can act as both a tumor suppressor and an oncoprotein, depending upon cellular context and identify it as a potential therapeutic target in cancer treatment. This review discusses the implications of Notch in a number of hematologic and solid malignancies and some of the currently available inhibitors developed against this pathway as potential cancer therapeutics. 

AB - Notch signalling is a conserved developmental pathway involved, inter alia, in cell-fate decision, morphogenesis and tissue patterning. Extensive research has linked this pathways with a variety of malignancies, cancer stem cell renewal, induction of epithelial-to-mesenchymal transition and tumor angiogenesis. These data indicate that Notch can act as both a tumor suppressor and an oncoprotein, depending upon cellular context and identify it as a potential therapeutic target in cancer treatment. This review discusses the implications of Notch in a number of hematologic and solid malignancies and some of the currently available inhibitors developed against this pathway as potential cancer therapeutics. 

KW - Notch

KW - Cancer

KW - Receptor

KW - Ligand

KW - Signalling

U2 - 10.14319/ijcto.44.17

DO - 10.14319/ijcto.44.17

M3 - Literature review

VL - 4

JO - International Journal of Cancer Therapy and Oncology

JF - International Journal of Cancer Therapy and Oncology

SN - 2330-4049

IS - 4

ER -