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Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC. / Pan, Po-Shen; Curtis, Fiona; Carroll, Chris et al.
In: Bioorganic and Medicinal Chemistry, Vol. 14, No. 14, 15.07.2006, p. 4731-4739.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Pan, P-S, Curtis, F, Carroll, C, Medina, I, Liotta, L, Sharples, G & McAlpine, S 2006, 'Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC', Bioorganic and Medicinal Chemistry, vol. 14, no. 14, pp. 4731-4739. https://doi.org/10.1016/j.bmc.2006.03.028

APA

Pan, P-S., Curtis, F., Carroll, C., Medina, I., Liotta, L., Sharples, G., & McAlpine, S. (2006). Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC. Bioorganic and Medicinal Chemistry, 14(14), 4731-4739. https://doi.org/10.1016/j.bmc.2006.03.028

Vancouver

Pan P-S, Curtis F, Carroll C, Medina I, Liotta L, Sharples G et al. Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC. Bioorganic and Medicinal Chemistry. 2006 Jul 15;14(14):4731-4739. doi: 10.1016/j.bmc.2006.03.028

Author

Pan, Po-Shen ; Curtis, Fiona ; Carroll, Chris et al. / Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC. In: Bioorganic and Medicinal Chemistry. 2006 ; Vol. 14, No. 14. pp. 4731-4739.

Bibtex

@article{93845f82f2fd4e06817a126050d3da87,
title = "Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC",
abstract = "Holliday junctions (HJs) are formed as transient DNA intermediates during site-specific and homologous recombination. Both of these genetic exchange pathways are critical for normal DNA metabolism and repair. Trapping HJs leads to bacterial cell death by preventing proper segregation of the resulting interlinked chromosomes. Macrocyclic peptides designed to target this intermediate were synthesized with the goal of identifying compounds with specificity for this unique molecular target. We discovered ten macrocycles, both hexameric and octameric peptides, capable of trapping HJs in vitro. Those macrocycles containing tyrosine residues proved most effective. These data demonstrate that C-2 symmetrical macrocycles offer excellent synthetic targets for the development of novel antibiotic agents. Furthermore, the active compounds identified provide valuable tools for probing different pathways of recombinational exchange.",
author = "Po-Shen Pan and Fiona Curtis and Chris Carroll and Irene Medina and Lisa Liotta and Gary Sharples and Shelli McAlpine",
year = "2006",
month = jul,
day = "15",
doi = "10.1016/j.bmc.2006.03.028",
language = "English",
volume = "14",
pages = "4731--4739",
journal = "Bioorganic and Medicinal Chemistry",
issn = "1464-3391",
publisher = "Elsevier Limited",
number = "14",

}

RIS

TY - JOUR

T1 - Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC

AU - Pan, Po-Shen

AU - Curtis, Fiona

AU - Carroll, Chris

AU - Medina, Irene

AU - Liotta, Lisa

AU - Sharples, Gary

AU - McAlpine, Shelli

PY - 2006/7/15

Y1 - 2006/7/15

N2 - Holliday junctions (HJs) are formed as transient DNA intermediates during site-specific and homologous recombination. Both of these genetic exchange pathways are critical for normal DNA metabolism and repair. Trapping HJs leads to bacterial cell death by preventing proper segregation of the resulting interlinked chromosomes. Macrocyclic peptides designed to target this intermediate were synthesized with the goal of identifying compounds with specificity for this unique molecular target. We discovered ten macrocycles, both hexameric and octameric peptides, capable of trapping HJs in vitro. Those macrocycles containing tyrosine residues proved most effective. These data demonstrate that C-2 symmetrical macrocycles offer excellent synthetic targets for the development of novel antibiotic agents. Furthermore, the active compounds identified provide valuable tools for probing different pathways of recombinational exchange.

AB - Holliday junctions (HJs) are formed as transient DNA intermediates during site-specific and homologous recombination. Both of these genetic exchange pathways are critical for normal DNA metabolism and repair. Trapping HJs leads to bacterial cell death by preventing proper segregation of the resulting interlinked chromosomes. Macrocyclic peptides designed to target this intermediate were synthesized with the goal of identifying compounds with specificity for this unique molecular target. We discovered ten macrocycles, both hexameric and octameric peptides, capable of trapping HJs in vitro. Those macrocycles containing tyrosine residues proved most effective. These data demonstrate that C-2 symmetrical macrocycles offer excellent synthetic targets for the development of novel antibiotic agents. Furthermore, the active compounds identified provide valuable tools for probing different pathways of recombinational exchange.

U2 - 10.1016/j.bmc.2006.03.028

DO - 10.1016/j.bmc.2006.03.028

M3 - Journal article

VL - 14

SP - 4731

EP - 4739

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

SN - 1464-3391

IS - 14

ER -