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Novel antibiotics: second generation macrocyclic peptides designed to trap Holliday junctions

Research output: Contribution to journalJournal article

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  • Lisa Liotta
  • Irene Medina
  • Jennifer Robinson
  • Chris Carroll
  • Po-Shen Pan
  • Ricardo Corral
  • Jennifer Johnston
  • Kristina Cook
  • Fiona Curtis
  • Gary Sharples
  • Shelli McAlpine
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<mark>Journal publication date</mark>8/11/2004
<mark>Journal</mark>Tetrahedron Letters
Issue number46
Volume45
Number of pages4
Pages (from-to)8447-8450
Publication statusPublished
Original languageEnglish

Abstract

Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on the C-2 symmetrical HJ. They were synthesized using a strategy that permits elucidation of the amino acid role in binding HJs. The syntheses of these macrocycles are an important step in the development of a new class of antibiotics.