Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Novel meloxicam releasing electrospun polymer/ceramic reinforced biodegradable membranes for periodontal regeneration applications
AU - Yar, M.
AU - Farooq, A.
AU - Shahzadi, L.
AU - Khan, A.S.
AU - Mahmood, N.
AU - Rauf, A.
AU - Chaudhry, A.A.
AU - Rehman, I.U.
PY - 2016/7/1
Y1 - 2016/7/1
N2 - Periodontal disease is associated with the destruction of periodontal tissues, along with other disorders/problems including inflammation of tissues and severe pain. This paper reports the synthesis of meloxicam (MX) immobilized biodegradable chitosan (CS)/poly(vinyl alcohol) (PVA)/hydroxyapatite (HA) based electrospun (e-spun) fibers and films. Electrospinning was employed to produce drug loaded fibrous mats, whereas films were generated by solvent casting method. In-vitro drug release from materials containing varying concentrations of MX revealed that the scaffolds containing higher amount of drug showed comparatively faster release. During initial first few hours fast release was noted from membranes and films; however after around 5 h sustained release was achieved. The hydrogels showed good swelling property, which is highly desired for soft tissue engineered implants. To investigate the biocompatibility of our synthesized materials, VERO cells (epithelial cells) were selected and cell culture results showed that these all materials were non-cytotoxic and also these cells were very well proliferated on these synthesized scaffolds. These properties along with the anti-inflammatory potential of our fabricated materials suggest their effective utilization in periodontital treatments. © 2016 Elsevier B.V. All rights reserved.
AB - Periodontal disease is associated with the destruction of periodontal tissues, along with other disorders/problems including inflammation of tissues and severe pain. This paper reports the synthesis of meloxicam (MX) immobilized biodegradable chitosan (CS)/poly(vinyl alcohol) (PVA)/hydroxyapatite (HA) based electrospun (e-spun) fibers and films. Electrospinning was employed to produce drug loaded fibrous mats, whereas films were generated by solvent casting method. In-vitro drug release from materials containing varying concentrations of MX revealed that the scaffolds containing higher amount of drug showed comparatively faster release. During initial first few hours fast release was noted from membranes and films; however after around 5 h sustained release was achieved. The hydrogels showed good swelling property, which is highly desired for soft tissue engineered implants. To investigate the biocompatibility of our synthesized materials, VERO cells (epithelial cells) were selected and cell culture results showed that these all materials were non-cytotoxic and also these cells were very well proliferated on these synthesized scaffolds. These properties along with the anti-inflammatory potential of our fabricated materials suggest their effective utilization in periodontital treatments. © 2016 Elsevier B.V. All rights reserved.
KW - Chitosan
KW - Hydroxyapatite
KW - NSAIDs
KW - Periodontitis
KW - VERO cells
KW - Biocompatibility
KW - Biodegradable polymers
KW - Cell culture
KW - Cells
KW - Chitin
KW - Cytology
KW - Drug products
KW - Histology
KW - Hydrogels
KW - Spinning (fibers)
KW - Swelling
KW - Tissue
KW - Anti-inflammatories
KW - Biodegradable membrane
KW - Electrospun polymers
KW - Solvent casting method
KW - Synthesized materials
KW - Vero cells
KW - Scaffolds (biology)
KW - artificial membrane
KW - biodegradable plastic
KW - chitosan
KW - drug implant
KW - hydroxyapatite
KW - meloxicam
KW - polyvinyl alcohol
KW - thiazine derivative
KW - thiazole derivative
KW - animal
KW - ceramics
KW - chemistry
KW - Chlorocebus aethiops
KW - periodontal disease
KW - pharmacokinetics
KW - pharmacology
KW - Vero cell line
KW - Animals
KW - Biodegradable Plastics
KW - Ceramics
KW - Cercopithecus aethiops
KW - Drug Implants
KW - Durapatite
KW - Membranes, Artificial
KW - Periodontal Diseases
KW - Polyvinyl Alcohol
KW - Thiazines
KW - Thiazoles
KW - Vero Cells
U2 - 10.1016/j.msec.2016.03.072
DO - 10.1016/j.msec.2016.03.072
M3 - Journal article
VL - 64
SP - 148
EP - 156
JO - Materials Science and Engineering: A
JF - Materials Science and Engineering: A
SN - 0921-5093
ER -