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    Rights statement: This is the peer reviewed version of the following article: Douglas TEL, Schietse J, Zima A, Gorodzha S, Parakhonskiy BV, KhaleNkow D, Shkarin R, Ivanova A, Baumbach T, Weinhardt V, Stevens CV, Vanhoorne V, Vervaet C, Balcaen L, Vanhaecke F, Slośarczyk A, Surmeneva MA, Surmenev RA, Skirtach AG. 2018. Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration: Physiochemical and microcomputer tomographical characterization. J Biomed Mater Res Part A 2018:106A:822–828 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.36277/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

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Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration: Physiochemical and microcomputer tomographical characterization

Research output: Contribution to journalJournal article

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  • Timothy Edward Lim Douglas
  • Josefien Schietse
  • Aneta Zima
  • Svetlana Gorodzha
  • Bogdan Parakhonskiy
  • Dmitry Khalenkow
  • Roman Shkarin
  • Anna Ivanova
  • Tilo Baumbach
  • Venera Weinhardt
  • Christian Stevens
  • Valerie Vanhoorne
  • Chris Vervaet
  • Lieve Balcaen
  • Frank Vanhaecke
  • Anna Slosarczyk
  • Maria Surmeneva
  • Roman Surmenev
  • Andre Skirtach
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<mark>Journal publication date</mark>03/2018
<mark>Journal</mark>Journal of Biomedical Materials Research Part A
Issue number3
Volume106
Number of pages7
Pages (from-to)822-828
StatePublished
Early online date29/11/17
Original languageEnglish

Abstract

Mineralized hydrogels are increasingly gaining attention as biomaterials for bone regeneration. The most common mineralization strategy has been addition of preformed inorganic particles during hydrogel formation. This maintains injectability. One common form of bone cement is formed by mixing particles of the highly reactive calcium phosphate alpha-tricalcium phosphate (α-TCP) with water to form hydroxyapatite (HA). The calcium ions released during this reaction can be exploited to crosslink anionic, calcium-binding polymers such as the polysaccharide gellan gum (GG) to induce hydrogel formation. In this study, three different amounts of α-TCP particles were added to GG polymer solution to generate novel, injectable hydrogel-inorganic composites. Distribution of the inorganic phase in the hydrogel was studied by high resolution microcomputer tomography (µCT). Gelation occurred within 30 min. α-TCP converted to HA. µCT revealed inhomogeneous distribution of the inorganic phase in the composites. These results demonstrate the potential of the composites as alternatives to traditional α-TCP bone cement and pave the way for incorporation of biologically active substances and in vitro and in vivo testing.

Bibliographic note

This is the peer reviewed version of the following article: Douglas TEL, Schietse J, Zima A, Gorodzha S, Parakhonskiy BV, KhaleNkow D, Shkarin R, Ivanova A, Baumbach T, Weinhardt V, Stevens CV, Vanhoorne V, Vervaet C, Balcaen L, Vanhaecke F, Slośarczyk A, Surmeneva MA, Surmenev RA, Skirtach AG. 2018. Novel self-gelling injectable hydrogel/alpha-tricalcium phosphate composites for bone regeneration: Physiochemical and microcomputer tomographical characterization. J Biomed Mater Res Part A 2018:106A:822–828 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/jbm.a.36277/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.