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Nuclear and mitochondrial DNA of the primate malarial parasite Plasmodium knowlesi

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Nuclear and mitochondrial DNA of the primate malarial parasite Plasmodium knowlesi. / Williamson, D H; Wilson, R J; Bates, P A et al.
In: Molecular and Biochemical Parasitology, Vol. 14, No. 2, 02.1985, p. 199-209.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Williamson, DH, Wilson, RJ, Bates, PA, McCready, S, Perler, F & Qiang, BU 1985, 'Nuclear and mitochondrial DNA of the primate malarial parasite Plasmodium knowlesi', Molecular and Biochemical Parasitology, vol. 14, no. 2, pp. 199-209. https://doi.org/10.1016/0166-6851(85)90038-6

APA

Williamson, D. H., Wilson, R. J., Bates, P. A., McCready, S., Perler, F., & Qiang, B. U. (1985). Nuclear and mitochondrial DNA of the primate malarial parasite Plasmodium knowlesi. Molecular and Biochemical Parasitology, 14(2), 199-209. https://doi.org/10.1016/0166-6851(85)90038-6

Vancouver

Williamson DH, Wilson RJ, Bates PA, McCready S, Perler F, Qiang BU. Nuclear and mitochondrial DNA of the primate malarial parasite Plasmodium knowlesi. Molecular and Biochemical Parasitology. 1985 Feb;14(2):199-209. doi: 10.1016/0166-6851(85)90038-6

Author

Williamson, D H ; Wilson, R J ; Bates, P A et al. / Nuclear and mitochondrial DNA of the primate malarial parasite Plasmodium knowlesi. In: Molecular and Biochemical Parasitology. 1985 ; Vol. 14, No. 2. pp. 199-209.

Bibtex

@article{4e367e6b1f0347ab97b077580c3e6ea7,
title = "Nuclear and mitochondrial DNA of the primate malarial parasite Plasmodium knowlesi",
abstract = "Restriction analyses and DNA/DNA hybridisation of parasite DNA isolated from monkeys infected with the malarial parasite Plasmodium knowlesi has permitted unambiguous identification of the nuclear DNA of this species. Its (G+C) content, as determined by estimations of buoyant density as well as by direct analysis, is about 38%, essentially indistinguishable from that of its primate laboratory host, and grossly different from that of the major human malaria parasite, P. falciparum, which has a (G+C) content of approx. 19%. In addition, gradient fractionation of total P. knowlesi DNA revealed a minor DNA component (approx. 1% of the total) with a (G+C) content of about 19%. This DNA comprises covalently closed circular molecules which have a contour length about 11.6 microns, carry a small cruciform structure, and are thought to originate in the parasite's mitochondria.",
keywords = "Plasmodium knowlesi, Malaria , Nuclear DNA , Mitochondrial DNAv",
author = "Williamson, {D H} and Wilson, {R J} and Bates, {P A} and S McCready and F Perler and Qiang, {B U}",
year = "1985",
month = feb,
doi = "10.1016/0166-6851(85)90038-6",
language = "English",
volume = "14",
pages = "199--209",
journal = "Molecular and Biochemical Parasitology",
issn = "0166-6851",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Nuclear and mitochondrial DNA of the primate malarial parasite Plasmodium knowlesi

AU - Williamson, D H

AU - Wilson, R J

AU - Bates, P A

AU - McCready, S

AU - Perler, F

AU - Qiang, B U

PY - 1985/2

Y1 - 1985/2

N2 - Restriction analyses and DNA/DNA hybridisation of parasite DNA isolated from monkeys infected with the malarial parasite Plasmodium knowlesi has permitted unambiguous identification of the nuclear DNA of this species. Its (G+C) content, as determined by estimations of buoyant density as well as by direct analysis, is about 38%, essentially indistinguishable from that of its primate laboratory host, and grossly different from that of the major human malaria parasite, P. falciparum, which has a (G+C) content of approx. 19%. In addition, gradient fractionation of total P. knowlesi DNA revealed a minor DNA component (approx. 1% of the total) with a (G+C) content of about 19%. This DNA comprises covalently closed circular molecules which have a contour length about 11.6 microns, carry a small cruciform structure, and are thought to originate in the parasite's mitochondria.

AB - Restriction analyses and DNA/DNA hybridisation of parasite DNA isolated from monkeys infected with the malarial parasite Plasmodium knowlesi has permitted unambiguous identification of the nuclear DNA of this species. Its (G+C) content, as determined by estimations of buoyant density as well as by direct analysis, is about 38%, essentially indistinguishable from that of its primate laboratory host, and grossly different from that of the major human malaria parasite, P. falciparum, which has a (G+C) content of approx. 19%. In addition, gradient fractionation of total P. knowlesi DNA revealed a minor DNA component (approx. 1% of the total) with a (G+C) content of about 19%. This DNA comprises covalently closed circular molecules which have a contour length about 11.6 microns, carry a small cruciform structure, and are thought to originate in the parasite's mitochondria.

KW - Plasmodium knowlesi

KW - Malaria

KW - Nuclear DNA

KW - Mitochondrial DNAv

U2 - 10.1016/0166-6851(85)90038-6

DO - 10.1016/0166-6851(85)90038-6

M3 - Journal article

C2 - 2985981

VL - 14

SP - 199

EP - 209

JO - Molecular and Biochemical Parasitology

JF - Molecular and Biochemical Parasitology

SN - 0166-6851

IS - 2

ER -