We have over 12,000 students, from over 100 countries, within one of the safest campuses in the UK


93% of Lancaster students go into work or further study within six months of graduating

Home > Research > Publications & Outputs > Nutritional Immunology: A Multi-Dimensional App...
View graph of relations

« Back

Nutritional Immunology: A Multi-Dimensional Approach

Research output: Contribution to journalEditorial


  • Fleur Ponton
  • Kenneth Wilson
  • Sheena C. Cotter
  • David Raubenheimer
  • Stephen J. Simpson
Article numbere1002223
Journal publication date12/2011
JournalPLoS Pathogens
Number of pages4
Original languageEnglish


Nutrition is critical to immune defence and resistance to pathogens, with consequences that affect the health, welfare, and reproductive success of individual organisms [1], [2], and also has profound ecological and evolutionary implications [3]–[5]. In humans, under-nutrition, notably of protein, is a major contributor to morbidity and mortality due to infectious diseases, particularly in the developing world [1]. Likewise, over-nutrition and its associated metabolic disorders may impair immune function, disrupt the relationship with symbiotic and commensal microbiota, and increase susceptibility to infectious disease [6]. Despite the undoubted importance of nutrition to immune defence, the challenge remains to capture the complexity of this relationship. There are three main aspects to this complexity: (i) nutrition is a complex multi-dimensional problem for hosts, pathogens, and commensals; (ii) host immunity is a complex, multi-dimensional trait; and (iii) nutrition and immunity interact via multiple direct and indirect pathways, including involvement of the host's microbiota.