Research output: Contribution to Journal/Magazine › Editorial › peer-review
Research output: Contribution to Journal/Magazine › Editorial › peer-review
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TY - JOUR
T1 - Nutritional Immunology: A Multi-Dimensional Approach
AU - Ponton, Fleur
AU - Wilson, Kenneth
AU - Cotter, Sheena C.
AU - Raubenheimer, David
AU - Simpson, Stephen J.
PY - 2011/12
Y1 - 2011/12
N2 - Nutrition is critical to immune defence and resistance to pathogens, with consequences that affect the health, welfare, and reproductive success of individual organisms [1], [2], and also has profound ecological and evolutionary implications [3]–[5]. In humans, under-nutrition, notably of protein, is a major contributor to morbidity and mortality due to infectious diseases, particularly in the developing world [1]. Likewise, over-nutrition and its associated metabolic disorders may impair immune function, disrupt the relationship with symbiotic and commensal microbiota, and increase susceptibility to infectious disease [6]. Despite the undoubted importance of nutrition to immune defence, the challenge remains to capture the complexity of this relationship. There are three main aspects to this complexity: (i) nutrition is a complex multi-dimensional problem for hosts, pathogens, and commensals; (ii) host immunity is a complex, multi-dimensional trait; and (iii) nutrition and immunity interact via multiple direct and indirect pathways, including involvement of the host's microbiota.
AB - Nutrition is critical to immune defence and resistance to pathogens, with consequences that affect the health, welfare, and reproductive success of individual organisms [1], [2], and also has profound ecological and evolutionary implications [3]–[5]. In humans, under-nutrition, notably of protein, is a major contributor to morbidity and mortality due to infectious diseases, particularly in the developing world [1]. Likewise, over-nutrition and its associated metabolic disorders may impair immune function, disrupt the relationship with symbiotic and commensal microbiota, and increase susceptibility to infectious disease [6]. Despite the undoubted importance of nutrition to immune defence, the challenge remains to capture the complexity of this relationship. There are three main aspects to this complexity: (i) nutrition is a complex multi-dimensional problem for hosts, pathogens, and commensals; (ii) host immunity is a complex, multi-dimensional trait; and (iii) nutrition and immunity interact via multiple direct and indirect pathways, including involvement of the host's microbiota.
KW - LARVAL HELIOTHIS-VIRESCENS
KW - ECOLOGICAL IMMUNOLOGY
KW - IMMUNE-SYSTEM
KW - SELENIUM SUPPLEMENTATION
KW - EVOLUTIONARY ECOLOGY
KW - FEEDING-BEHAVIOR
KW - INNATE IMMUNITY
KW - GUT MICROBIOME
KW - PROTEIN COSTS
KW - TRADE-OFFS
U2 - 10.1371/journal.ppat.1002223
DO - 10.1371/journal.ppat.1002223
M3 - Editorial
VL - 7
SP - -
JO - PLoS Pathogens
JF - PLoS Pathogens
SN - 1553-7374
IS - 12
M1 - e1002223
ER -