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Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity

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Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity. / Martinez Corrales, Guillermo; Filer, Danny; Wenz, Katharina C. et al.
In: Cell Reports, Vol. 30, No. 6, 11.02.2020, p. 1661-1669.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Martinez Corrales, G, Filer, D, Wenz, KC, Rogan, A, Phillips, G, Li, M, Feseha, Y, Broughton, S & Alic, N 2020, 'Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity', Cell Reports, vol. 30, no. 6, pp. 1661-1669. https://doi.org/10.1016/j.celrep.2020.01.017

APA

Martinez Corrales, G., Filer, D., Wenz, K. C., Rogan, A., Phillips, G., Li, M., Feseha, Y., Broughton, S., & Alic, N. (2020). Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity. Cell Reports, 30(6), 1661-1669. https://doi.org/10.1016/j.celrep.2020.01.017

Vancouver

Martinez Corrales G, Filer D, Wenz KC, Rogan A, Phillips G, Li M et al. Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity. Cell Reports. 2020 Feb 11;30(6):1661-1669. doi: 10.1016/j.celrep.2020.01.017

Author

Martinez Corrales, Guillermo ; Filer, Danny ; Wenz, Katharina C. et al. / Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity. In: Cell Reports. 2020 ; Vol. 30, No. 6. pp. 1661-1669.

Bibtex

@article{4752c943698745d3bf795a37bf4bc297,
title = "Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity",
abstract = "Health and survival in old age can be improved by changes in gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task is to generate the pre-ribosomal RNA (rRNA). We find that reducing the levels of Pol I activity is sufficient to extend lifespan in the fruit fly. This effect can be recapitulated by partial, adult-restricted inhibition, with both enterocytes and stem cells of the adult midgut emerging as important cell types. In stem cells, Pol I appears to act in the same longevity pathway as Pol III, implicating rRNA synthesis in these cells as the key lifespan determinant. Importantly, reduction in Pol I activity delays broad, agerelated impairment and pathology, improving the function of diverse organ systems. Hence, our study shows that Pol I activity in the adult drives systemic, age-related decline in animal health and anticipates mortality.",
keywords = "RNA polymerase I, aging, ribosomal RNA/DNA, Drosophila, old-age health, lifespan, longevity",
author = "{Martinez Corrales}, Guillermo and Danny Filer and Wenz, {Katharina C.} and Abbie Rogan and George Phillips and Mengjia Li and Yodit Feseha and Susan Broughton and Nazif Alic",
year = "2020",
month = feb,
day = "11",
doi = "10.1016/j.celrep.2020.01.017",
language = "English",
volume = "30",
pages = "1661--1669",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - Partial Inhibition of RNA Polymerase I Promotes Animal Health and Longevity

AU - Martinez Corrales, Guillermo

AU - Filer, Danny

AU - Wenz, Katharina C.

AU - Rogan, Abbie

AU - Phillips, George

AU - Li, Mengjia

AU - Feseha, Yodit

AU - Broughton, Susan

AU - Alic, Nazif

PY - 2020/2/11

Y1 - 2020/2/11

N2 - Health and survival in old age can be improved by changes in gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task is to generate the pre-ribosomal RNA (rRNA). We find that reducing the levels of Pol I activity is sufficient to extend lifespan in the fruit fly. This effect can be recapitulated by partial, adult-restricted inhibition, with both enterocytes and stem cells of the adult midgut emerging as important cell types. In stem cells, Pol I appears to act in the same longevity pathway as Pol III, implicating rRNA synthesis in these cells as the key lifespan determinant. Importantly, reduction in Pol I activity delays broad, agerelated impairment and pathology, improving the function of diverse organ systems. Hence, our study shows that Pol I activity in the adult drives systemic, age-related decline in animal health and anticipates mortality.

AB - Health and survival in old age can be improved by changes in gene expression. RNA polymerase (Pol) I is the essential, conserved enzyme whose task is to generate the pre-ribosomal RNA (rRNA). We find that reducing the levels of Pol I activity is sufficient to extend lifespan in the fruit fly. This effect can be recapitulated by partial, adult-restricted inhibition, with both enterocytes and stem cells of the adult midgut emerging as important cell types. In stem cells, Pol I appears to act in the same longevity pathway as Pol III, implicating rRNA synthesis in these cells as the key lifespan determinant. Importantly, reduction in Pol I activity delays broad, agerelated impairment and pathology, improving the function of diverse organ systems. Hence, our study shows that Pol I activity in the adult drives systemic, age-related decline in animal health and anticipates mortality.

KW - RNA polymerase I

KW - aging

KW - ribosomal RNA/DNA

KW - Drosophila

KW - old-age health

KW - lifespan

KW - longevity

U2 - 10.1016/j.celrep.2020.01.017

DO - 10.1016/j.celrep.2020.01.017

M3 - Journal article

VL - 30

SP - 1661

EP - 1669

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 6

ER -