Home > Research > Publications & Outputs > Pectin coatings on titanium alloy scaffolds pro...

Electronic data

  • MLBLUE-D-18-00536R1

    Rights statement: This is the author’s version of a work that was accepted for publication in Materials Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Materials Letters, 227, 2018 DOI: 10.1016/j.matlet.2018.05.060

    Accepted author manuscript, 692 KB, PDF-document

    Embargo ends: 26/05/19

    Available under license: CC BY-NC-ND: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License

Links

Text available via DOI:

View graph of relations

Pectin coatings on titanium alloy scaffolds produced by additive manufacturing: Promotion of human bone marrow stromal cell proliferation

Research output: Contribution to journalJournal article

Published
  • Timothy Edward Lim Douglas
  • Ute Hempel
  • Jagoda Zydek
  • Alina Vladescu
  • Krzysztof Pietryga
  • Julia Kaeswurm
  • Maria Buchweitz
  • Roman Surmenev
  • Maria Surmeneva
  • Cosmin Cotrut
  • Andrey Koptyug
  • Elzbieta Pamula
Close
<mark>Journal publication date</mark>15/09/2018
<mark>Journal</mark>Materials Letters
Volume227
Number of pages4
Pages (from-to)225-228
StatePublished
Early online date26/05/18
Original languageEnglish

Abstract

Ti6Al4V is a popular biomaterial for load-bearing implants for bone contact, which can be fabricated by additive manufacturing technologies. Their long-term success depends on their stable anchoring in surrounding bone, which in turn depends on formation of new bone tissue on the implant surface, for which adhesion and proliferation of bone-forming cells is a pre-requisite. Hence, surface coatings which promote cell adhesion and proliferation are desirable.

Here, Ti6Al4V discs prepared by additive manufacturing (EBM) were coated with layers of pectins, calcium-binding polysaccharides derived from citrus (C) and apple (A), which also contained alkaline phosphatase (ALP), the enzyme responsible for mineralization of bone tissue.

Adhesion and proliferation of human bone marrow stromal cells (hBMSC) were assessed. Proliferation after 7 days was increased by A-ALP coatings and, in particular, by C-ALP coatings. Cell morphology was similar on coated and uncoated samples. In conclusion, ALP-loaded pectin coatings promote hBMSC adhesion and proliferation.

Bibliographic note

This is the author’s version of a work that was accepted for publication in Materials Letters. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Materials Letters, 227, 2018 DOI: 10.1016/j.matlet.2018.05.060