Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Perfect Simulation From Nonneutral Population Genetic Models: Variable Population Size and Population Subdivision.
AU - Fearnhead, Paul
PY - 2006/11
Y1 - 2006/11
N2 - We show how the idea of monotone coupling from the past can produce simple algorithms for simulating samples at a nonneutral locus under a range of demographic models. We specifically consider a biallelic locus and either a general variable population size mode or a general migration model for population subdivision. We investigate the effect of demography on the efficacy of selection and the effect of selection on genetic divergence between populations.
AB - We show how the idea of monotone coupling from the past can produce simple algorithms for simulating samples at a nonneutral locus under a range of demographic models. We specifically consider a biallelic locus and either a general variable population size mode or a general migration model for population subdivision. We investigate the effect of demography on the efficacy of selection and the effect of selection on genetic divergence between populations.
U2 - 10.1534/genetics.106.060681
DO - 10.1534/genetics.106.060681
M3 - Journal article
VL - 174
SP - 1397
EP - 1406
JO - Genetics
JF - Genetics
SN - 1943-2631
ER -