Rights statement: This is the author’s version of a work that was accepted for publication in Acta Tropica. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Acta Tropica, 212, 2020 DOI: 10.1016/j.actatropica.2020.105646
Accepted author manuscript, 1.65 MB, PDF document
Available under license: CC BY-NC-ND
Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Piloting an integrated approach for estimation of environmental risk of Schistosoma haematobium infections in pre-school-aged children and their mothers at Barombi Kotto, Cameroon
AU - Eyre, Max
AU - Stanton, Michelle
AU - Macklin, G.
AU - Bartoníček, Z.
AU - O'Halloran, L.
AU - Ombede, Dieudonné R Eloundou
AU - Chuinteu, G.D.
N1 - This is the author’s version of a work that was accepted for publication in Acta Tropica. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Acta Tropica, 212, 2020 DOI: 10.1016/j.actatropica.2020.105646
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Within schistosomiasis control, assessing environmental risk of currently non-treated demographic groups e.g. pre-school-aged children (PSAC) and their mothers is important. We conducted a pilot micro-epidemiological assessment at the crater lake of Barombi Kotto, Cameroon with GPS tracking and infection data from 12 PSAC-mother pairs (n = 24) overlaid against environmental sampling inclusive of snail, parasite and water-use information. Several high-risk locations or ‘hotspots’ with elevated water contact, increased intermediate snail host densities and detectable schistosome environmental DNA (eDNA) were identified. Exposure between PSAC and mother pairs was temporally and spatially associated, suggesting interventions which can benefit both groups simultaneously might be feasible. When attempting to interrupt parasite transmission in future, overlaid maps of snail, parasite and water contact data can guide fine-scale spatial targeting of environmental interventions.
AB - Within schistosomiasis control, assessing environmental risk of currently non-treated demographic groups e.g. pre-school-aged children (PSAC) and their mothers is important. We conducted a pilot micro-epidemiological assessment at the crater lake of Barombi Kotto, Cameroon with GPS tracking and infection data from 12 PSAC-mother pairs (n = 24) overlaid against environmental sampling inclusive of snail, parasite and water-use information. Several high-risk locations or ‘hotspots’ with elevated water contact, increased intermediate snail host densities and detectable schistosome environmental DNA (eDNA) were identified. Exposure between PSAC and mother pairs was temporally and spatially associated, suggesting interventions which can benefit both groups simultaneously might be feasible. When attempting to interrupt parasite transmission in future, overlaid maps of snail, parasite and water contact data can guide fine-scale spatial targeting of environmental interventions.
KW - micro-epidemiology
KW - urogenital schistosomiasis
KW - GPS datalogging
KW - snail survey
KW - environmental DNA
KW - Cameroon
KW - pre-school-aged children
KW - mothers
U2 - 10.1016/j.actatropica.2020.105646
DO - 10.1016/j.actatropica.2020.105646
M3 - Journal article
VL - 212
JO - Acta Tropica
JF - Acta Tropica
SN - 0001-706X
M1 - 105646
ER -