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  • Mayes-Hardy-Schmidt-accepted

    Rights statement: This is the author’s version of a work that was accepted for publication in Acta Biomaterialia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Acta Biomaterialia, 106, 2020 DOI: 10.1016/j.actbio.2020.02.027

    Accepted author manuscript, 1.62 MB, PDF document

    Embargo ends: 22/02/21

    Available under license: CC BY-NC-ND

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Polysaccharide-based films for the prevention of unwanted postoperative adhesions at biological interfaces

Research output: Contribution to journalJournal article

Published
  • Sarah M. Mayes
  • Jessica Davis
  • Jessica Scott
  • Vanessa Aguilar
  • Scott A. Zawko
  • Steve Swinnea
  • Daniel L. Peterson
  • John G. Hardy
  • Christine E. Schmidt
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<mark>Journal publication date</mark>1/04/2020
<mark>Journal</mark>Acta Biomaterialia
Volume106
Number of pages10
Pages (from-to)92-101
Publication statusPublished
Early online date22/02/20
Original languageEnglish

Abstract

Postoperative adhesions protect, repair, and supply nutrients to injured tissues; however, such adhesions often remain permanent and complicate otherwise successful surgeries by tethering tissues together that are normally separated. An ideal adhesion barrier should not only effectively prevent unwanted adhesions but should be easy to use, however, those that are currently available have inconsistent efficacy and are difficult to handle or to apply. A robust hydrogel film composed of alginate and a photo-crosslinkable hyaluronic acid (HA) derivative (glycidyl methacrylate functionalized hyaluronic acid (GMHA)) represents a solution to this problem. A sacrificial porogen (urea) was used in the film manufacture process to impart macropores that yield films that are more malleable and tougher than equivalent films produced without the sacrificial porogen. The robust mechanical behavior of these templated alginate/GMHA films directly facilitated handling characteristics of the barrier film. In a rat peritoneal abrasion model for adhesion formation, the polysaccharide films successfully prevented adhesions with statistical equivalence to the leading anti-adhesion technology on the market, Seprafilm®. Statement of Significance: Postoperative adhesions often remain permanent and complicate otherwise successful surgeries by tethering tissues together that are normally separated and pose potentially significant challenges to patients. Therefore, the generation of adhesion barriers that are easy to deploy during surgery and effectively prevent unwanted adhesions is a big challenge. In this study robust hydrogel films composed of alginate and a photo-crosslinkable hyaluronic acid (HA) derivative (glycidyl methacrylate functionalized HA, GMHA) were fabricated and investigated for their potential to act as a solution to this problem using a rat peritoneal abrasion model for adhesion formation. We observed the polysaccharide films successfully prevented adhesions with statistical equivalence to the leading anti-adhesion technology on the market, Seprafilm®, suggesting that such films represent a promising strategy for the prevention of postoperative adhesions.

Bibliographic note

This is the author’s version of a work that was accepted for publication in Acta Biomaterialia. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Acta Biomaterialia, 106, 2020 DOI: 10.1016/j.actbio.2020.02.027