Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Polyurethane membranes modified with isopropyl myristate as a potential candidate for encapsulating electronic implants: A study of biocompatibility and water permeability
AU - Roohpour, N.
AU - Wasikiewicz, J.M.
AU - Moshaverinia, A.
AU - Paul, D.
AU - Grahn, M.F.
AU - Rehman, I.U.
AU - Vadgama, P.
PY - 2010
Y1 - 2010
N2 - Medical polyurethanes have shown good bio-stability and mechanical properties and have been used as coating for implantable medical devices. However, despite their excellent properties, they are relatively permeable to liquid water and water vapour which is a drawback for electronic implant encapsulation. In this study polyether polyurethanes with different soft segment molecular weights were modified by incorporating isopropyl myristate (IPM), as a hydrophobic modifying agent, and the effect of IPM on water resistant and biocompatibility of membranes were investigated. IPM changed the surface properties of the polyurethane film and reduced its surface energy. Polyurethane films were found to be stable with IPM concentrations of 1-5 wt% based upon their chemistry; however it leached out in BSA at higher concentrations. Though, low concentrations of IPM reduced both liquid water and water vapour permeability; at higher IPM content liquid permeability did not improved significantly. In general, the polyurethane materials showed much lower water permeability compared with currently used silicone packaging material for electronic implants. In addition, cytotoxicity assessment of IPM containing polyurethanes showed no evidence of cytotoxcity up to 5 wt% IPM. © 2010 by the authors.
AB - Medical polyurethanes have shown good bio-stability and mechanical properties and have been used as coating for implantable medical devices. However, despite their excellent properties, they are relatively permeable to liquid water and water vapour which is a drawback for electronic implant encapsulation. In this study polyether polyurethanes with different soft segment molecular weights were modified by incorporating isopropyl myristate (IPM), as a hydrophobic modifying agent, and the effect of IPM on water resistant and biocompatibility of membranes were investigated. IPM changed the surface properties of the polyurethane film and reduced its surface energy. Polyurethane films were found to be stable with IPM concentrations of 1-5 wt% based upon their chemistry; however it leached out in BSA at higher concentrations. Though, low concentrations of IPM reduced both liquid water and water vapour permeability; at higher IPM content liquid permeability did not improved significantly. In general, the polyurethane materials showed much lower water permeability compared with currently used silicone packaging material for electronic implants. In addition, cytotoxicity assessment of IPM containing polyurethanes showed no evidence of cytotoxcity up to 5 wt% IPM. © 2010 by the authors.
KW - Biocompatibility
KW - Implantable devices
KW - Isopropyl myristate
KW - Polyurethane
KW - Water permeability
KW - Cytotoxcity
KW - Cytotoxicity assessment
KW - Implantable medical devices
KW - Liquid permeability
KW - Liquid water
KW - Low concentrations
KW - Modifying agents
KW - Polyurethane films
KW - Polyurethane materials
KW - Polyurethane membranes
KW - Soft segments
KW - Surface energies
KW - Water resistant
KW - Water vapour
KW - Water vapour permeability
KW - Biological membranes
KW - Biomedical engineering
KW - Encapsulation
KW - Implants (surgical)
KW - Leaching
KW - Liquids
KW - Mechanical properties
KW - Packaging materials
KW - Polyurethanes
KW - Silicones
KW - Surface chemistry
KW - Surface properties
KW - Water content
U2 - 10.3390/polym2030102
DO - 10.3390/polym2030102
M3 - Journal article
VL - 2
SP - 102
EP - 119
JO - Polymers
JF - Polymers
SN - 2073-4360
IS - 3
ER -