Research output: Contribution to Journal/Magazine › Journal article › peer-review
<mark>Journal publication date</mark> | 4/04/2006 |
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<mark>Journal</mark> | SYNLETT |
Issue number | 6 |
Volume | 2006 |
Number of pages | 4 |
Pages (from-to) | 889-892 |
Publication Status | Published |
<mark>Original language</mark> | English |
A practical, safe, high-yielding and efficient synthesis of (S)-pyrrolidin-2-yl-1H-tetrazole has been developed, which avoids the generation of ammonium azide in the cyclisation step and the use of a 9:1 acetic acid-water mixture as the solvent in the hydrogenation. The previously extended hydrogenolysis reaction time (three days) is now reduced to hours through the use of an H-Cube (TM) (a continuous-flow reactor employing a mixed hydrogen-liquid flow stream).