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Preliminary study of laser doppler perfusion signal by wavelet transform in patients with critical limb ischemia before and after revascularization

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Preliminary study of laser doppler perfusion signal by wavelet transform in patients with critical limb ischemia before and after revascularization. / Ticcinelli, Valentina; Martini, Romeo; Bagno, Andrea.
In: Clinical Hemorheology and Microcirculation, Vol. 58, No. 3, 2014, p. 415-428.

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Ticcinelli V, Martini R, Bagno A. Preliminary study of laser doppler perfusion signal by wavelet transform in patients with critical limb ischemia before and after revascularization. Clinical Hemorheology and Microcirculation. 2014;58(3):415-428. Epub 2013 Oct 29. doi: 10.3233/CH-131797

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Ticcinelli, Valentina ; Martini, Romeo ; Bagno, Andrea. / Preliminary study of laser doppler perfusion signal by wavelet transform in patients with critical limb ischemia before and after revascularization. In: Clinical Hemorheology and Microcirculation. 2014 ; Vol. 58, No. 3. pp. 415-428.

Bibtex

@article{c9cef01133a74184a2c588a0ec6c6f18,
title = "Preliminary study of laser doppler perfusion signal by wavelet transform in patients with critical limb ischemia before and after revascularization",
abstract = "The haemodynamics of skin microcirculation can be quantitatively evaluated by Laser Doppler Fluxmetry (LDF). LDF signal in human skin shows periodic oscillations. Spectral analysis by wavelet transform displays six characteristic frequency intervals (FI) from 0.005 to 2 Hz, related to distinct vascular structures activities: heart (0.6-2 Hz), sympathetic respiratory (0.145-0.6 Hz), myogenic (0.052-0.145 Hz), local sympathetic nerve (0.021-0.052 Hz) and endothelial cells NO dependent (0.0095-0.021 Hz) and NO independent (0.005-0.0095 Hz). The most advanced stage of peripheral arterial obstructive disease is the critical limb ischemia (CLI), which causes the reduction of blood perfusion threatening limb viability. Besides macrocirculatory alterations, many studies have shown microvascular misdistribution of skin blood flow as the main factor that leads patients to CLI. Revascularization can save limb and patient's life, too. In the present study, LDF signals have been recorded on the skin of the foot dorsum in 15 patients suffering from CLI. LDF signals have been analyzed before and after limb revascularization by means of the wavelet analysis. Significant changes in frequency distribution before and after limb revascularization have been detected: the median normalized values of spectral power increases for 49.8% (p = 0.0341) in the frequency range 0.050328-0.053707 Hz, whereas spectral power decreases for 77.1% (p = 0.0179) in the frequency range 0.018988-0.029284 Hz. We can conclude that changes in the frequency intervals occur after revascularization, shifting from a prevailing endothelial activity toward a prevailing sympathetic activity.",
keywords = "Laser doppler, vasomotion , critical limb ischemia , wavelet transform",
author = "Valentina Ticcinelli and Romeo Martini and Andrea Bagno",
year = "2014",
doi = "10.3233/CH-131797",
language = "English",
volume = "58",
pages = "415--428",
journal = "Clinical Hemorheology and Microcirculation",
issn = "1875-8622",
publisher = "IOS Press",
number = "3",

}

RIS

TY - JOUR

T1 - Preliminary study of laser doppler perfusion signal by wavelet transform in patients with critical limb ischemia before and after revascularization

AU - Ticcinelli, Valentina

AU - Martini, Romeo

AU - Bagno, Andrea

PY - 2014

Y1 - 2014

N2 - The haemodynamics of skin microcirculation can be quantitatively evaluated by Laser Doppler Fluxmetry (LDF). LDF signal in human skin shows periodic oscillations. Spectral analysis by wavelet transform displays six characteristic frequency intervals (FI) from 0.005 to 2 Hz, related to distinct vascular structures activities: heart (0.6-2 Hz), sympathetic respiratory (0.145-0.6 Hz), myogenic (0.052-0.145 Hz), local sympathetic nerve (0.021-0.052 Hz) and endothelial cells NO dependent (0.0095-0.021 Hz) and NO independent (0.005-0.0095 Hz). The most advanced stage of peripheral arterial obstructive disease is the critical limb ischemia (CLI), which causes the reduction of blood perfusion threatening limb viability. Besides macrocirculatory alterations, many studies have shown microvascular misdistribution of skin blood flow as the main factor that leads patients to CLI. Revascularization can save limb and patient's life, too. In the present study, LDF signals have been recorded on the skin of the foot dorsum in 15 patients suffering from CLI. LDF signals have been analyzed before and after limb revascularization by means of the wavelet analysis. Significant changes in frequency distribution before and after limb revascularization have been detected: the median normalized values of spectral power increases for 49.8% (p = 0.0341) in the frequency range 0.050328-0.053707 Hz, whereas spectral power decreases for 77.1% (p = 0.0179) in the frequency range 0.018988-0.029284 Hz. We can conclude that changes in the frequency intervals occur after revascularization, shifting from a prevailing endothelial activity toward a prevailing sympathetic activity.

AB - The haemodynamics of skin microcirculation can be quantitatively evaluated by Laser Doppler Fluxmetry (LDF). LDF signal in human skin shows periodic oscillations. Spectral analysis by wavelet transform displays six characteristic frequency intervals (FI) from 0.005 to 2 Hz, related to distinct vascular structures activities: heart (0.6-2 Hz), sympathetic respiratory (0.145-0.6 Hz), myogenic (0.052-0.145 Hz), local sympathetic nerve (0.021-0.052 Hz) and endothelial cells NO dependent (0.0095-0.021 Hz) and NO independent (0.005-0.0095 Hz). The most advanced stage of peripheral arterial obstructive disease is the critical limb ischemia (CLI), which causes the reduction of blood perfusion threatening limb viability. Besides macrocirculatory alterations, many studies have shown microvascular misdistribution of skin blood flow as the main factor that leads patients to CLI. Revascularization can save limb and patient's life, too. In the present study, LDF signals have been recorded on the skin of the foot dorsum in 15 patients suffering from CLI. LDF signals have been analyzed before and after limb revascularization by means of the wavelet analysis. Significant changes in frequency distribution before and after limb revascularization have been detected: the median normalized values of spectral power increases for 49.8% (p = 0.0341) in the frequency range 0.050328-0.053707 Hz, whereas spectral power decreases for 77.1% (p = 0.0179) in the frequency range 0.018988-0.029284 Hz. We can conclude that changes in the frequency intervals occur after revascularization, shifting from a prevailing endothelial activity toward a prevailing sympathetic activity.

KW - Laser doppler

KW - vasomotion

KW - critical limb ischemia

KW - wavelet transform

U2 - 10.3233/CH-131797

DO - 10.3233/CH-131797

M3 - Journal article

C2 - 24169097

VL - 58

SP - 415

EP - 428

JO - Clinical Hemorheology and Microcirculation

JF - Clinical Hemorheology and Microcirculation

SN - 1875-8622

IS - 3

ER -