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Preparation and characterization of a novel bioactive restorative composite based on covalently coupled polyurethane-nanohydroxyapatite fibres

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Preparation and characterization of a novel bioactive restorative composite based on covalently coupled polyurethane-nanohydroxyapatite fibres. / Khan, A.S.; Ahmad, Z.; Edirisinghe, M.J.; Wong, F.S.L.; Rehman, I.U.

In: Acta Biomaterialia, Vol. 4, No. 5, 2008, p. 1275-1287.

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Khan, A.S. ; Ahmad, Z. ; Edirisinghe, M.J. ; Wong, F.S.L. ; Rehman, I.U. / Preparation and characterization of a novel bioactive restorative composite based on covalently coupled polyurethane-nanohydroxyapatite fibres. In: Acta Biomaterialia. 2008 ; Vol. 4, No. 5. pp. 1275-1287.

Bibtex

@article{7f0385a26430474091df1819af2ca39a,
title = "Preparation and characterization of a novel bioactive restorative composite based on covalently coupled polyurethane-nanohydroxyapatite fibres",
abstract = "Nanohydroxyapatite (n-HAp) was prepared using a sol-gel method. n-HAp powder was obtained from the gel form by heat treatment followed by grinding using ball milling. A novel polyurethane composite material was prepared by chemically binding the hydroxyapatite to the diisocyanate component in the polyurethane backbone through solvent polymerization. The procedure involved the stepwise addition of monomeric units of the polyurethane and optimizing the reagent concentrations. The resultant composite material was electrospun to form fibre mats. The fibres were less than 1 μm in thickness and contained no beads or irregularities. Chemical structural characterization of both the ceramics and the novel polymers were carried out by Fourier transform infrared and Raman spectroscopy. X-ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy and Brunauer-Emmett-Teller surface area analysis were also employed to observe the crystal lattice and size and surface area of the n-HAp. Further characterization (by energy-dispersive X-ray analysis and SEM) of the spun fibres revealed the presence of elements associated with hydroxyapatite and polyurethane without the presence of any loose particles of hydroxyapatite, indicating the formation of the covalent bond between the ceramics and the polymer backbone. {\textcopyright} 2008 Acta Materialia Inc.",
keywords = "Electrospun fibres, FTIR and Raman spectroscopy, Hydroxyapatite, Polyurethane, SEM, hydroxyapatite, nanohydroxyapatite, polymer, polyurethan, reagent, solvent, addition reaction, article, ceramics, chemical binding, chemical structure, composite material, covalent bond, crystal structure, gel, heat treatment, infrared spectroscopy, polymerization, powder, priority journal, Raman spectrometry, scanning electron microscopy, transmission electron microscopy, X ray diffraction",
author = "A.S. Khan and Z. Ahmad and M.J. Edirisinghe and F.S.L. Wong and I.U. Rehman",
year = "2008",
doi = "10.1016/j.actbio.2008.04.016",
language = "English",
volume = "4",
pages = "1275--1287",
journal = "Acta Biomaterialia",
issn = "1742-7061",
publisher = "Elsevier BV",
number = "5",

}

RIS

TY - JOUR

T1 - Preparation and characterization of a novel bioactive restorative composite based on covalently coupled polyurethane-nanohydroxyapatite fibres

AU - Khan, A.S.

AU - Ahmad, Z.

AU - Edirisinghe, M.J.

AU - Wong, F.S.L.

AU - Rehman, I.U.

PY - 2008

Y1 - 2008

N2 - Nanohydroxyapatite (n-HAp) was prepared using a sol-gel method. n-HAp powder was obtained from the gel form by heat treatment followed by grinding using ball milling. A novel polyurethane composite material was prepared by chemically binding the hydroxyapatite to the diisocyanate component in the polyurethane backbone through solvent polymerization. The procedure involved the stepwise addition of monomeric units of the polyurethane and optimizing the reagent concentrations. The resultant composite material was electrospun to form fibre mats. The fibres were less than 1 μm in thickness and contained no beads or irregularities. Chemical structural characterization of both the ceramics and the novel polymers were carried out by Fourier transform infrared and Raman spectroscopy. X-ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy and Brunauer-Emmett-Teller surface area analysis were also employed to observe the crystal lattice and size and surface area of the n-HAp. Further characterization (by energy-dispersive X-ray analysis and SEM) of the spun fibres revealed the presence of elements associated with hydroxyapatite and polyurethane without the presence of any loose particles of hydroxyapatite, indicating the formation of the covalent bond between the ceramics and the polymer backbone. © 2008 Acta Materialia Inc.

AB - Nanohydroxyapatite (n-HAp) was prepared using a sol-gel method. n-HAp powder was obtained from the gel form by heat treatment followed by grinding using ball milling. A novel polyurethane composite material was prepared by chemically binding the hydroxyapatite to the diisocyanate component in the polyurethane backbone through solvent polymerization. The procedure involved the stepwise addition of monomeric units of the polyurethane and optimizing the reagent concentrations. The resultant composite material was electrospun to form fibre mats. The fibres were less than 1 μm in thickness and contained no beads or irregularities. Chemical structural characterization of both the ceramics and the novel polymers were carried out by Fourier transform infrared and Raman spectroscopy. X-ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy and Brunauer-Emmett-Teller surface area analysis were also employed to observe the crystal lattice and size and surface area of the n-HAp. Further characterization (by energy-dispersive X-ray analysis and SEM) of the spun fibres revealed the presence of elements associated with hydroxyapatite and polyurethane without the presence of any loose particles of hydroxyapatite, indicating the formation of the covalent bond between the ceramics and the polymer backbone. © 2008 Acta Materialia Inc.

KW - Electrospun fibres

KW - FTIR and Raman spectroscopy

KW - Hydroxyapatite

KW - Polyurethane

KW - SEM

KW - hydroxyapatite

KW - nanohydroxyapatite

KW - polymer

KW - polyurethan

KW - reagent

KW - solvent

KW - addition reaction

KW - article

KW - ceramics

KW - chemical binding

KW - chemical structure

KW - composite material

KW - covalent bond

KW - crystal structure

KW - gel

KW - heat treatment

KW - infrared spectroscopy

KW - polymerization

KW - powder

KW - priority journal

KW - Raman spectrometry

KW - scanning electron microscopy

KW - transmission electron microscopy

KW - X ray diffraction

U2 - 10.1016/j.actbio.2008.04.016

DO - 10.1016/j.actbio.2008.04.016

M3 - Journal article

VL - 4

SP - 1275

EP - 1287

JO - Acta Biomaterialia

JF - Acta Biomaterialia

SN - 1742-7061

IS - 5

ER -