Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Preparation and characterization of multiactive electrospun fibers
T2 - Poly-ε-carpolactone fibers loaded with hydroxyapatite and selected NSAIDs
AU - Karavasili, C.
AU - Bouropoulos, N.
AU - Kontopoulou, I.
AU - Smith, A.
AU - Van Der Merwe, S.M.
AU - Rehman, I.U.R.
AU - Ahmad, Z.
AU - Fatouros, D.G.
PY - 2014
Y1 - 2014
N2 - Electrospun poly-ε-caprolactone fibers were employed as hosts for hydroxypatite and nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen (IBU) and indomethacin (INDO) (separately). The fibers (size range between 400 and 20 μm) were characterized by means of X-ray diffraction, differential scanning calorimetry, fourier-transform infrared spectroscopy and scanning electron microscopy. The physicochemical characterization of the fibers indicated that the drugs are associated with the fibers in an amorphous state. The release of IBU and INDO was monitored in PBS pH 7.4. A rapid release was observed for both drugs. Finally, bioactivity studies in simulated body fluid revealed the formation of hydroxyapatite, indicating that the fibers could be further utilized as materials for coupled (or multipurpose) biomedical and biomaterial engineering applications. © 2013 Wiley Periodicals, Inc.
AB - Electrospun poly-ε-caprolactone fibers were employed as hosts for hydroxypatite and nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen (IBU) and indomethacin (INDO) (separately). The fibers (size range between 400 and 20 μm) were characterized by means of X-ray diffraction, differential scanning calorimetry, fourier-transform infrared spectroscopy and scanning electron microscopy. The physicochemical characterization of the fibers indicated that the drugs are associated with the fibers in an amorphous state. The release of IBU and INDO was monitored in PBS pH 7.4. A rapid release was observed for both drugs. Finally, bioactivity studies in simulated body fluid revealed the formation of hydroxyapatite, indicating that the fibers could be further utilized as materials for coupled (or multipurpose) biomedical and biomaterial engineering applications. © 2013 Wiley Periodicals, Inc.
KW - bioactive and multiactive
KW - electrospinning
KW - hydroxyapatite
KW - poly(ε- caprolactone)
KW - poorly soluble drugs
KW - Biological materials
KW - Biomaterials
KW - Differential scanning calorimetry
KW - Drug products
KW - Electrospinning
KW - Hydroxyapatite
KW - Scanning electron microscopy
KW - X ray diffraction
KW - Biomaterial engineerings
KW - Caprolactone
KW - Electrospun fibers
KW - Nonsteroidal anti-inflammatory drugs
KW - Physico-chemical characterization
KW - Poorly soluble drugs
KW - Simulated body fluids
KW - Fibers
KW - ibuprofen
KW - indometacin
KW - polycaprolactone
KW - nonsteroid antiinflammatory agent
KW - polyester
KW - article
KW - controlled study
KW - differential scanning calorimetry
KW - drug absorption
KW - drug formulation
KW - drug release
KW - encapsulation
KW - fiber
KW - in vitro study
KW - infrared spectroscopy
KW - molecular weight
KW - scanning electron microscopy
KW - chemistry
KW - drug delivery system
KW - procedures
KW - synthesis
KW - Anti-Inflammatory Agents, Non-Steroidal
KW - Calorimetry, Differential Scanning
KW - Drug Delivery Systems
KW - Durapatite
KW - Ibuprofen
KW - Indomethacin
KW - Microscopy, Electron, Scanning
KW - Polyesters
KW - Spectroscopy, Fourier Transform Infrared
KW - X-Ray Diffraction
U2 - 10.1002/jbm.a.34931
DO - 10.1002/jbm.a.34931
M3 - Journal article
VL - 102
SP - 2583
EP - 2589
JO - Journal of Biomedical Materials Research Part A
JF - Journal of Biomedical Materials Research Part A
SN - 1549-3296
IS - 8
ER -