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Preparation and characterization of multiactive electrospun fibers: Poly-ε-carpolactone fibers loaded with hydroxyapatite and selected NSAIDs

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Preparation and characterization of multiactive electrospun fibers : Poly-ε-carpolactone fibers loaded with hydroxyapatite and selected NSAIDs. / Karavasili, C.; Bouropoulos, N.; Kontopoulou, I.; Smith, A.; Van Der Merwe, S.M.; Rehman, I.U.R.; Ahmad, Z.; Fatouros, D.G.

In: Journal of Biomedical Materials Research Part A, Vol. 102, No. 8, 2014, p. 2583-2589.

Research output: Contribution to journalJournal article

Harvard

Karavasili, C, Bouropoulos, N, Kontopoulou, I, Smith, A, Van Der Merwe, SM, Rehman, IUR, Ahmad, Z & Fatouros, DG 2014, 'Preparation and characterization of multiactive electrospun fibers: Poly-ε-carpolactone fibers loaded with hydroxyapatite and selected NSAIDs', Journal of Biomedical Materials Research Part A, vol. 102, no. 8, pp. 2583-2589. https://doi.org/10.1002/jbm.a.34931

APA

Karavasili, C., Bouropoulos, N., Kontopoulou, I., Smith, A., Van Der Merwe, S. M., Rehman, I. U. R., Ahmad, Z., & Fatouros, D. G. (2014). Preparation and characterization of multiactive electrospun fibers: Poly-ε-carpolactone fibers loaded with hydroxyapatite and selected NSAIDs. Journal of Biomedical Materials Research Part A, 102(8), 2583-2589. https://doi.org/10.1002/jbm.a.34931

Vancouver

Karavasili C, Bouropoulos N, Kontopoulou I, Smith A, Van Der Merwe SM, Rehman IUR et al. Preparation and characterization of multiactive electrospun fibers: Poly-ε-carpolactone fibers loaded with hydroxyapatite and selected NSAIDs. Journal of Biomedical Materials Research Part A. 2014;102(8):2583-2589. https://doi.org/10.1002/jbm.a.34931

Author

Karavasili, C. ; Bouropoulos, N. ; Kontopoulou, I. ; Smith, A. ; Van Der Merwe, S.M. ; Rehman, I.U.R. ; Ahmad, Z. ; Fatouros, D.G. / Preparation and characterization of multiactive electrospun fibers : Poly-ε-carpolactone fibers loaded with hydroxyapatite and selected NSAIDs. In: Journal of Biomedical Materials Research Part A. 2014 ; Vol. 102, No. 8. pp. 2583-2589.

Bibtex

@article{4bdb85db003745b8bbe6d4b6c41d68cd,
title = "Preparation and characterization of multiactive electrospun fibers: Poly-ε-carpolactone fibers loaded with hydroxyapatite and selected NSAIDs",
abstract = "Electrospun poly-ε-caprolactone fibers were employed as hosts for hydroxypatite and nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen (IBU) and indomethacin (INDO) (separately). The fibers (size range between 400 and 20 μm) were characterized by means of X-ray diffraction, differential scanning calorimetry, fourier-transform infrared spectroscopy and scanning electron microscopy. The physicochemical characterization of the fibers indicated that the drugs are associated with the fibers in an amorphous state. The release of IBU and INDO was monitored in PBS pH 7.4. A rapid release was observed for both drugs. Finally, bioactivity studies in simulated body fluid revealed the formation of hydroxyapatite, indicating that the fibers could be further utilized as materials for coupled (or multipurpose) biomedical and biomaterial engineering applications. {\textcopyright} 2013 Wiley Periodicals, Inc.",
keywords = "bioactive and multiactive, electrospinning, hydroxyapatite, poly(ε- caprolactone), poorly soluble drugs, Biological materials, Biomaterials, Differential scanning calorimetry, Drug products, Electrospinning, Hydroxyapatite, Scanning electron microscopy, X ray diffraction, Biomaterial engineerings, Caprolactone, Electrospun fibers, Nonsteroidal anti-inflammatory drugs, Physico-chemical characterization, Poorly soluble drugs, Simulated body fluids, Fibers, ibuprofen, indometacin, polycaprolactone, nonsteroid antiinflammatory agent, polyester, article, controlled study, differential scanning calorimetry, drug absorption, drug formulation, drug release, encapsulation, fiber, in vitro study, infrared spectroscopy, molecular weight, scanning electron microscopy, chemistry, drug delivery system, procedures, synthesis, Anti-Inflammatory Agents, Non-Steroidal, Calorimetry, Differential Scanning, Drug Delivery Systems, Durapatite, Ibuprofen, Indomethacin, Microscopy, Electron, Scanning, Polyesters, Spectroscopy, Fourier Transform Infrared, X-Ray Diffraction",
author = "C. Karavasili and N. Bouropoulos and I. Kontopoulou and A. Smith and {Van Der Merwe}, S.M. and I.U.R. Rehman and Z. Ahmad and D.G. Fatouros",
year = "2014",
doi = "10.1002/jbm.a.34931",
language = "English",
volume = "102",
pages = "2583--2589",
journal = "Journal of Biomedical Materials Research Part A",
issn = "1549-3296",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Preparation and characterization of multiactive electrospun fibers

T2 - Poly-ε-carpolactone fibers loaded with hydroxyapatite and selected NSAIDs

AU - Karavasili, C.

AU - Bouropoulos, N.

AU - Kontopoulou, I.

AU - Smith, A.

AU - Van Der Merwe, S.M.

AU - Rehman, I.U.R.

AU - Ahmad, Z.

AU - Fatouros, D.G.

PY - 2014

Y1 - 2014

N2 - Electrospun poly-ε-caprolactone fibers were employed as hosts for hydroxypatite and nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen (IBU) and indomethacin (INDO) (separately). The fibers (size range between 400 and 20 μm) were characterized by means of X-ray diffraction, differential scanning calorimetry, fourier-transform infrared spectroscopy and scanning electron microscopy. The physicochemical characterization of the fibers indicated that the drugs are associated with the fibers in an amorphous state. The release of IBU and INDO was monitored in PBS pH 7.4. A rapid release was observed for both drugs. Finally, bioactivity studies in simulated body fluid revealed the formation of hydroxyapatite, indicating that the fibers could be further utilized as materials for coupled (or multipurpose) biomedical and biomaterial engineering applications. © 2013 Wiley Periodicals, Inc.

AB - Electrospun poly-ε-caprolactone fibers were employed as hosts for hydroxypatite and nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen (IBU) and indomethacin (INDO) (separately). The fibers (size range between 400 and 20 μm) were characterized by means of X-ray diffraction, differential scanning calorimetry, fourier-transform infrared spectroscopy and scanning electron microscopy. The physicochemical characterization of the fibers indicated that the drugs are associated with the fibers in an amorphous state. The release of IBU and INDO was monitored in PBS pH 7.4. A rapid release was observed for both drugs. Finally, bioactivity studies in simulated body fluid revealed the formation of hydroxyapatite, indicating that the fibers could be further utilized as materials for coupled (or multipurpose) biomedical and biomaterial engineering applications. © 2013 Wiley Periodicals, Inc.

KW - bioactive and multiactive

KW - electrospinning

KW - hydroxyapatite

KW - poly(ε- caprolactone)

KW - poorly soluble drugs

KW - Biological materials

KW - Biomaterials

KW - Differential scanning calorimetry

KW - Drug products

KW - Electrospinning

KW - Hydroxyapatite

KW - Scanning electron microscopy

KW - X ray diffraction

KW - Biomaterial engineerings

KW - Caprolactone

KW - Electrospun fibers

KW - Nonsteroidal anti-inflammatory drugs

KW - Physico-chemical characterization

KW - Poorly soluble drugs

KW - Simulated body fluids

KW - Fibers

KW - ibuprofen

KW - indometacin

KW - polycaprolactone

KW - nonsteroid antiinflammatory agent

KW - polyester

KW - article

KW - controlled study

KW - differential scanning calorimetry

KW - drug absorption

KW - drug formulation

KW - drug release

KW - encapsulation

KW - fiber

KW - in vitro study

KW - infrared spectroscopy

KW - molecular weight

KW - scanning electron microscopy

KW - chemistry

KW - drug delivery system

KW - procedures

KW - synthesis

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Calorimetry, Differential Scanning

KW - Drug Delivery Systems

KW - Durapatite

KW - Ibuprofen

KW - Indomethacin

KW - Microscopy, Electron, Scanning

KW - Polyesters

KW - Spectroscopy, Fourier Transform Infrared

KW - X-Ray Diffraction

U2 - 10.1002/jbm.a.34931

DO - 10.1002/jbm.a.34931

M3 - Journal article

VL - 102

SP - 2583

EP - 2589

JO - Journal of Biomedical Materials Research Part A

JF - Journal of Biomedical Materials Research Part A

SN - 1549-3296

IS - 8

ER -