Rights statement: This is the author’s version of a work that was accepted for publication in Chemical Data Collections. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Chemical Data Collections, 9-10, 2017 DOI: 10.1016/j.cdc.2016.11.007
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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Preparation, characterization and in vitro antioxidant and cytotoxicity studies of some 2,4-dichloro-N-[di(alkyl/aryl)carbamothioyl]benzamide derivatives
AU - Gunasekaran, Nanjappan
AU - Vadivel, Vellingiri
AU - Halcovitch, Nathan R.
AU - Tiekink, Edward R.T.
N1 - This is the author’s version of a work that was accepted for publication in Chemical Data Collections. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Chemical Data Collections, 9-10, 2017 DOI: 10.1016/j.cdc.2016.11.007
PY - 2017/8
Y1 - 2017/8
N2 - Abstract In the present study, three biologically active, substituted acyl thiourea compounds (1–3) have been synthesized from 2,4-dichlorobenzoyl chloride, potassium thiocyanate and the corresponding secondary amine in dry acetone. As analytical and spectral data of 1 and 3 have already been discussed in the literature, only the compound 2 was characterized by elemental analyses, UV–Visible, FT–IR, 1H & 13C NMR spectroscopic techniques. The molecular structures of 1–3 were determined by single crystal X-ray crystallography which shows twists of up to 70° about the (S=)C–NC(=O) bonds. All the synthesized compounds show good antioxidant property and cytotoxic potential against Ehrlich Ascites Carcinoma (EAC) cancer cell line.
AB - Abstract In the present study, three biologically active, substituted acyl thiourea compounds (1–3) have been synthesized from 2,4-dichlorobenzoyl chloride, potassium thiocyanate and the corresponding secondary amine in dry acetone. As analytical and spectral data of 1 and 3 have already been discussed in the literature, only the compound 2 was characterized by elemental analyses, UV–Visible, FT–IR, 1H & 13C NMR spectroscopic techniques. The molecular structures of 1–3 were determined by single crystal X-ray crystallography which shows twists of up to 70° about the (S=)C–NC(=O) bonds. All the synthesized compounds show good antioxidant property and cytotoxic potential against Ehrlich Ascites Carcinoma (EAC) cancer cell line.
KW - Thiourea derivatives
KW - X-ray crystallography
KW - Antioxidant activity
KW - Cytotoxicity
KW - EAC cell line
U2 - 10.1016/j.cdc.2016.11.007
DO - 10.1016/j.cdc.2016.11.007
M3 - Journal article
VL - 9-10
SP - 263
EP - 276
JO - Chemical Data Collections
JF - Chemical Data Collections
SN - 2405-8300
ER -