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    Rights statement: This is the author’s version of a work that was accepted for publication in Chemical Data Collections. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Chemical Data Collections, 9-10, 2017 DOI: 10.1016/j.cdc.2016.11.007

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Preparation, characterization and in vitro antioxidant and cytotoxicity studies of some 2,4-dichloro-N-[di(alkyl/aryl)carbamothioyl]benzamide derivatives

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Preparation, characterization and in vitro antioxidant and cytotoxicity studies of some 2,4-dichloro-N-[di(alkyl/aryl)carbamothioyl]benzamide derivatives. / Gunasekaran, Nanjappan; Vadivel, Vellingiri; Halcovitch, Nathan R. et al.
In: Chemical Data Collections, Vol. 9-10, 08.2017, p. 263-276.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Gunasekaran N, Vadivel V, Halcovitch NR, Tiekink ERT. Preparation, characterization and in vitro antioxidant and cytotoxicity studies of some 2,4-dichloro-N-[di(alkyl/aryl)carbamothioyl]benzamide derivatives. Chemical Data Collections. 2017 Aug;9-10:263-276. Epub 2016 Nov 29. doi: 10.1016/j.cdc.2016.11.007

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@article{844d1ff278e54a1fb4e9ba1ee3dccf12,
title = "Preparation, characterization and in vitro antioxidant and cytotoxicity studies of some 2,4-dichloro-N-[di(alkyl/aryl)carbamothioyl]benzamide derivatives",
abstract = "Abstract In the present study, three biologically active, substituted acyl thiourea compounds (1–3) have been synthesized from 2,4-dichlorobenzoyl chloride, potassium thiocyanate and the corresponding secondary amine in dry acetone. As analytical and spectral data of 1 and 3 have already been discussed in the literature, only the compound 2 was characterized by elemental analyses, UV–Visible, FT–IR, 1H & 13C NMR spectroscopic techniques. The molecular structures of 1–3 were determined by single crystal X-ray crystallography which shows twists of up to 70° about the (S=)C–NC(=O) bonds. All the synthesized compounds show good antioxidant property and cytotoxic potential against Ehrlich Ascites Carcinoma (EAC) cancer cell line.",
keywords = "Thiourea derivatives, X-ray crystallography, Antioxidant activity, Cytotoxicity, EAC cell line",
author = "Nanjappan Gunasekaran and Vellingiri Vadivel and Halcovitch, {Nathan R.} and Tiekink, {Edward R.T.}",
note = "This is the author{\textquoteright}s version of a work that was accepted for publication in Chemical Data Collections. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Chemical Data Collections, 9-10, 2017 DOI: 10.1016/j.cdc.2016.11.007",
year = "2017",
month = aug,
doi = "10.1016/j.cdc.2016.11.007",
language = "English",
volume = "9-10",
pages = "263--276",
journal = "Chemical Data Collections",
issn = "2405-8300",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Preparation, characterization and in vitro antioxidant and cytotoxicity studies of some 2,4-dichloro-N-[di(alkyl/aryl)carbamothioyl]benzamide derivatives

AU - Gunasekaran, Nanjappan

AU - Vadivel, Vellingiri

AU - Halcovitch, Nathan R.

AU - Tiekink, Edward R.T.

N1 - This is the author’s version of a work that was accepted for publication in Chemical Data Collections. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Chemical Data Collections, 9-10, 2017 DOI: 10.1016/j.cdc.2016.11.007

PY - 2017/8

Y1 - 2017/8

N2 - Abstract In the present study, three biologically active, substituted acyl thiourea compounds (1–3) have been synthesized from 2,4-dichlorobenzoyl chloride, potassium thiocyanate and the corresponding secondary amine in dry acetone. As analytical and spectral data of 1 and 3 have already been discussed in the literature, only the compound 2 was characterized by elemental analyses, UV–Visible, FT–IR, 1H & 13C NMR spectroscopic techniques. The molecular structures of 1–3 were determined by single crystal X-ray crystallography which shows twists of up to 70° about the (S=)C–NC(=O) bonds. All the synthesized compounds show good antioxidant property and cytotoxic potential against Ehrlich Ascites Carcinoma (EAC) cancer cell line.

AB - Abstract In the present study, three biologically active, substituted acyl thiourea compounds (1–3) have been synthesized from 2,4-dichlorobenzoyl chloride, potassium thiocyanate and the corresponding secondary amine in dry acetone. As analytical and spectral data of 1 and 3 have already been discussed in the literature, only the compound 2 was characterized by elemental analyses, UV–Visible, FT–IR, 1H & 13C NMR spectroscopic techniques. The molecular structures of 1–3 were determined by single crystal X-ray crystallography which shows twists of up to 70° about the (S=)C–NC(=O) bonds. All the synthesized compounds show good antioxidant property and cytotoxic potential against Ehrlich Ascites Carcinoma (EAC) cancer cell line.

KW - Thiourea derivatives

KW - X-ray crystallography

KW - Antioxidant activity

KW - Cytotoxicity

KW - EAC cell line

U2 - 10.1016/j.cdc.2016.11.007

DO - 10.1016/j.cdc.2016.11.007

M3 - Journal article

VL - 9-10

SP - 263

EP - 276

JO - Chemical Data Collections

JF - Chemical Data Collections

SN - 2405-8300

ER -