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P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

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P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. / Lindsay, Colin R.; Lawn, Samuel; Campbell, Andrew D.; Faller, William J.; Rambow, Florian; Mort, Richard L.; Timpson, Paul; Li, Ang; Cammareri, Patrizia; Ridgway, Rachel A.; Morton, Jennifer P.; Doyle, Brendan; Hegarty, Shauna; Rafferty, Mairin; Murphy, Ian G.; McDermott, Enda W.; Sheahan, Kieran; Pedone, Katherine; Finn, Alexander J.; Groben, Pamela A.; Thomas, Nancy E.; Hao, Honglin; Carson, Craig; Norman, Jim C.; Machesky, Laura M.; Gallagher, William M.; Jackson, Ian J.; Van Kempen, Leon; Beermann, Friedrich; Der, Channing; Larue, Lionel; Welch, Heidi C.; Ozanne, Brad W.; Sansom, Owen J.

In: Nature Communications, Vol. 2, 555, 22.11.2011.

Research output: Contribution to journalJournal article

Harvard

Lindsay, CR, Lawn, S, Campbell, AD, Faller, WJ, Rambow, F, Mort, RL, Timpson, P, Li, A, Cammareri, P, Ridgway, RA, Morton, JP, Doyle, B, Hegarty, S, Rafferty, M, Murphy, IG, McDermott, EW, Sheahan, K, Pedone, K, Finn, AJ, Groben, PA, Thomas, NE, Hao, H, Carson, C, Norman, JC, Machesky, LM, Gallagher, WM, Jackson, IJ, Van Kempen, L, Beermann, F, Der, C, Larue, L, Welch, HC, Ozanne, BW & Sansom, OJ 2011, 'P-Rex1 is required for efficient melanoblast migration and melanoma metastasis', Nature Communications, vol. 2, 555. https://doi.org/10.1038/ncomms1560

APA

Lindsay, C. R., Lawn, S., Campbell, A. D., Faller, W. J., Rambow, F., Mort, R. L., Timpson, P., Li, A., Cammareri, P., Ridgway, R. A., Morton, J. P., Doyle, B., Hegarty, S., Rafferty, M., Murphy, I. G., McDermott, E. W., Sheahan, K., Pedone, K., Finn, A. J., ... Sansom, O. J. (2011). P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nature Communications, 2, [555]. https://doi.org/10.1038/ncomms1560

Vancouver

Lindsay CR, Lawn S, Campbell AD, Faller WJ, Rambow F, Mort RL et al. P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. Nature Communications. 2011 Nov 22;2. 555. https://doi.org/10.1038/ncomms1560

Author

Lindsay, Colin R. ; Lawn, Samuel ; Campbell, Andrew D. ; Faller, William J. ; Rambow, Florian ; Mort, Richard L. ; Timpson, Paul ; Li, Ang ; Cammareri, Patrizia ; Ridgway, Rachel A. ; Morton, Jennifer P. ; Doyle, Brendan ; Hegarty, Shauna ; Rafferty, Mairin ; Murphy, Ian G. ; McDermott, Enda W. ; Sheahan, Kieran ; Pedone, Katherine ; Finn, Alexander J. ; Groben, Pamela A. ; Thomas, Nancy E. ; Hao, Honglin ; Carson, Craig ; Norman, Jim C. ; Machesky, Laura M. ; Gallagher, William M. ; Jackson, Ian J. ; Van Kempen, Leon ; Beermann, Friedrich ; Der, Channing ; Larue, Lionel ; Welch, Heidi C. ; Ozanne, Brad W. ; Sansom, Owen J. / P-Rex1 is required for efficient melanoblast migration and melanoma metastasis. In: Nature Communications. 2011 ; Vol. 2.

Bibtex

@article{2c4dc1445cab4f5988ad474a6d8a36c8,
title = "P-Rex1 is required for efficient melanoblast migration and melanoma metastasis",
abstract = "Metastases are the major cause of death from melanoma, a skin cancer that has the fastest rising incidence of any malignancy in the Western world. Molecular pathways that drive melanoblast migration in development are believed to underpin the movement and ultimately the metastasis of melanoma. Here we show that mice lacking P-Rex1, a Rac-specific Rho GTPase guanine nucleotide exchange factor, have a melanoblast migration defect during development evidenced by a white belly. Moreover, these P-Rex1(-/-) mice are resistant to metastasis when crossed to a murine model of melanoma. Mechanistically, this is associated with P-Rex1 driving invasion in a Rac-dependent manner. P-Rex1 is elevated in the majority of human melanoma cell lines and tumour tissue. We conclude that P-Rex1 has an important role in melanoblast migration and cancer progression to metastasis in mice and humans.",
keywords = "Animals, Cell Movement, Cells, Cultured, Guanine Nucleotide Exchange Factors, Humans, Immunohistochemistry, In Vitro Techniques, Melanoma, Mice, Mice, Inbred C57BL, Mice, Knockout, Neoplasm Metastasis, Tissue Array Analysis, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't",
author = "Lindsay, {Colin R.} and Samuel Lawn and Campbell, {Andrew D.} and Faller, {William J.} and Florian Rambow and Mort, {Richard L.} and Paul Timpson and Ang Li and Patrizia Cammareri and Ridgway, {Rachel A.} and Morton, {Jennifer P.} and Brendan Doyle and Shauna Hegarty and Mairin Rafferty and Murphy, {Ian G.} and McDermott, {Enda W.} and Kieran Sheahan and Katherine Pedone and Finn, {Alexander J.} and Groben, {Pamela A.} and Thomas, {Nancy E.} and Honglin Hao and Craig Carson and Norman, {Jim C.} and Machesky, {Laura M.} and Gallagher, {William M.} and Jackson, {Ian J.} and {Van Kempen}, Leon and Friedrich Beermann and Channing Der and Lionel Larue and Welch, {Heidi C.} and Ozanne, {Brad W.} and Sansom, {Owen J.}",
year = "2011",
month = nov
day = "22",
doi = "10.1038/ncomms1560",
language = "English",
volume = "2",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - P-Rex1 is required for efficient melanoblast migration and melanoma metastasis

AU - Lindsay, Colin R.

AU - Lawn, Samuel

AU - Campbell, Andrew D.

AU - Faller, William J.

AU - Rambow, Florian

AU - Mort, Richard L.

AU - Timpson, Paul

AU - Li, Ang

AU - Cammareri, Patrizia

AU - Ridgway, Rachel A.

AU - Morton, Jennifer P.

AU - Doyle, Brendan

AU - Hegarty, Shauna

AU - Rafferty, Mairin

AU - Murphy, Ian G.

AU - McDermott, Enda W.

AU - Sheahan, Kieran

AU - Pedone, Katherine

AU - Finn, Alexander J.

AU - Groben, Pamela A.

AU - Thomas, Nancy E.

AU - Hao, Honglin

AU - Carson, Craig

AU - Norman, Jim C.

AU - Machesky, Laura M.

AU - Gallagher, William M.

AU - Jackson, Ian J.

AU - Van Kempen, Leon

AU - Beermann, Friedrich

AU - Der, Channing

AU - Larue, Lionel

AU - Welch, Heidi C.

AU - Ozanne, Brad W.

AU - Sansom, Owen J.

PY - 2011/11/22

Y1 - 2011/11/22

N2 - Metastases are the major cause of death from melanoma, a skin cancer that has the fastest rising incidence of any malignancy in the Western world. Molecular pathways that drive melanoblast migration in development are believed to underpin the movement and ultimately the metastasis of melanoma. Here we show that mice lacking P-Rex1, a Rac-specific Rho GTPase guanine nucleotide exchange factor, have a melanoblast migration defect during development evidenced by a white belly. Moreover, these P-Rex1(-/-) mice are resistant to metastasis when crossed to a murine model of melanoma. Mechanistically, this is associated with P-Rex1 driving invasion in a Rac-dependent manner. P-Rex1 is elevated in the majority of human melanoma cell lines and tumour tissue. We conclude that P-Rex1 has an important role in melanoblast migration and cancer progression to metastasis in mice and humans.

AB - Metastases are the major cause of death from melanoma, a skin cancer that has the fastest rising incidence of any malignancy in the Western world. Molecular pathways that drive melanoblast migration in development are believed to underpin the movement and ultimately the metastasis of melanoma. Here we show that mice lacking P-Rex1, a Rac-specific Rho GTPase guanine nucleotide exchange factor, have a melanoblast migration defect during development evidenced by a white belly. Moreover, these P-Rex1(-/-) mice are resistant to metastasis when crossed to a murine model of melanoma. Mechanistically, this is associated with P-Rex1 driving invasion in a Rac-dependent manner. P-Rex1 is elevated in the majority of human melanoma cell lines and tumour tissue. We conclude that P-Rex1 has an important role in melanoblast migration and cancer progression to metastasis in mice and humans.

KW - Animals

KW - Cell Movement

KW - Cells, Cultured

KW - Guanine Nucleotide Exchange Factors

KW - Humans

KW - Immunohistochemistry

KW - In Vitro Techniques

KW - Melanoma

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - Neoplasm Metastasis

KW - Tissue Array Analysis

KW - Journal Article

KW - Research Support, N.I.H., Extramural

KW - Research Support, Non-U.S. Gov't

U2 - 10.1038/ncomms1560

DO - 10.1038/ncomms1560

M3 - Journal article

C2 - 22109529

VL - 2

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 555

ER -