Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

Biomedical and Life Sciences

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https://doi.org/10.1016/j.ejphar.2010.10.059
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Keywords

Animals, Blood Glucose, Cognition Disorders, Dietary Fats, Gastric Inhibitory Polypeptide, Glucose Intolerance, Hippocampus, Homeostasis, Insulin, Insulin Resistance, Long-Term Potentiation, Male, Mice, Obesity, Receptors, Gastrointestinal Hormone

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Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice. / Porter, David W.; Irwin, Nigel; Flatt, Peter R. et al.
In: European Journal of Pharmacology, Vol. 650, No. 2-3, 15.01.2011, p. 688-693.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Author

Porter, David W. ; Irwin, Nigel ; Flatt, Peter R. et al. / Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice. In: European Journal of Pharmacology. 2011 ; Vol. 650, No. 2-3. pp. 688-693.

Bibtex

@article{f6729de0bc1c4c2283bc309e44fae372,

title = "Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice",

abstract = "Enzyme-resistant glucose-dependent insulinotropic polypeptide (GIP) agonists offer therapeutic potential for type 2 diabetes treatment. In addition, there is emerging evidence suggesting that GIP plays a direct role in modulating aspects of brain function. This study compared effects of dietary modification and/or twice-daily injection of the stable GIP agonist, (d-Ala(2))GIP, on metabolic control, cognitive function and hippocampal synaptic plasticity in high-fat fed mice. Young Swiss mice were maintained on high-fat diet for 155 days, at which point half of the animals were switched to standard maintenance diet. Mice were subsequently injected with (d-Ala(2))GIP (25 nmol/kg bodyweight; b.i.d.) or saline vehicle for 28 days. Both dietary intervention and (d-Ala(2))GIP treatment were equally effective in restoring non-fasting glycaemic control (P",

keywords = "Animals, Blood Glucose, Cognition Disorders, Dietary Fats, Gastric Inhibitory Polypeptide, Glucose Intolerance, Hippocampus, Homeostasis, Insulin, Insulin Resistance, Long-Term Potentiation, Male, Mice, Obesity, Receptors, Gastrointestinal Hormone",

author = "Porter, {David W.} and Nigel Irwin and Flatt, {Peter R.} and Christian H{\"o}lscher and Gault, {Victor A.}",

year = "2011",

month = jan,

day = "15",

doi = "10.1016/j.ejphar.2010.10.059",

language = "English",

volume = "650",

pages = "688--693",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier",

number = "2-3",

}

RIS

TY - JOUR

T1 - Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice

AU - Porter, David W.

AU - Irwin, Nigel

AU - Flatt, Peter R.

AU - Hölscher, Christian

AU - Gault, Victor A.

PY - 2011/1/15

Y1 - 2011/1/15

N2 - Enzyme-resistant glucose-dependent insulinotropic polypeptide (GIP) agonists offer therapeutic potential for type 2 diabetes treatment. In addition, there is emerging evidence suggesting that GIP plays a direct role in modulating aspects of brain function. This study compared effects of dietary modification and/or twice-daily injection of the stable GIP agonist, (d-Ala(2))GIP, on metabolic control, cognitive function and hippocampal synaptic plasticity in high-fat fed mice. Young Swiss mice were maintained on high-fat diet for 155 days, at which point half of the animals were switched to standard maintenance diet. Mice were subsequently injected with (d-Ala(2))GIP (25 nmol/kg bodyweight; b.i.d.) or saline vehicle for 28 days. Both dietary intervention and (d-Ala(2))GIP treatment were equally effective in restoring non-fasting glycaemic control (P

AB - Enzyme-resistant glucose-dependent insulinotropic polypeptide (GIP) agonists offer therapeutic potential for type 2 diabetes treatment. In addition, there is emerging evidence suggesting that GIP plays a direct role in modulating aspects of brain function. This study compared effects of dietary modification and/or twice-daily injection of the stable GIP agonist, (d-Ala(2))GIP, on metabolic control, cognitive function and hippocampal synaptic plasticity in high-fat fed mice. Young Swiss mice were maintained on high-fat diet for 155 days, at which point half of the animals were switched to standard maintenance diet. Mice were subsequently injected with (d-Ala(2))GIP (25 nmol/kg bodyweight; b.i.d.) or saline vehicle for 28 days. Both dietary intervention and (d-Ala(2))GIP treatment were equally effective in restoring non-fasting glycaemic control (P

KW - Animals

KW - Blood Glucose

KW - Cognition Disorders

KW - Dietary Fats

KW - Gastric Inhibitory Polypeptide

KW - Glucose Intolerance

KW - Hippocampus

KW - Homeostasis

KW - Insulin

KW - Insulin Resistance

KW - Long-Term Potentiation

KW - Male

KW - Mice

KW - Obesity

KW - Receptors, Gastrointestinal Hormone

U2 - 10.1016/j.ejphar.2010.10.059

DO - 10.1016/j.ejphar.2010.10.059

M3 - Journal article

C2 - 21050845

VL - 650

SP - 688

EP - 693

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2-3

ER -

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