Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Prolonged GIP receptor activation improves cognitive function, hippocampal synaptic plasticity and glucose homeostasis in high-fat fed mice
AU - Porter, David W.
AU - Irwin, Nigel
AU - Flatt, Peter R.
AU - Hölscher, Christian
AU - Gault, Victor A.
N1 - Copyright © 2010 Elsevier B.V. All rights reserved.
PY - 2011/1/15
Y1 - 2011/1/15
N2 - Enzyme-resistant glucose-dependent insulinotropic polypeptide (GIP) agonists offer therapeutic potential for type 2 diabetes treatment. In addition, there is emerging evidence suggesting that GIP plays a direct role in modulating aspects of brain function. This study compared effects of dietary modification and/or twice-daily injection of the stable GIP agonist, (d-Ala(2))GIP, on metabolic control, cognitive function and hippocampal synaptic plasticity in high-fat fed mice. Young Swiss mice were maintained on high-fat diet for 155 days, at which point half of the animals were switched to standard maintenance diet. Mice were subsequently injected with (d-Ala(2))GIP (25 nmol/kg bodyweight; b.i.d.) or saline vehicle for 28 days. Both dietary intervention and (d-Ala(2))GIP treatment were equally effective in restoring non-fasting glycaemic control (P
AB - Enzyme-resistant glucose-dependent insulinotropic polypeptide (GIP) agonists offer therapeutic potential for type 2 diabetes treatment. In addition, there is emerging evidence suggesting that GIP plays a direct role in modulating aspects of brain function. This study compared effects of dietary modification and/or twice-daily injection of the stable GIP agonist, (d-Ala(2))GIP, on metabolic control, cognitive function and hippocampal synaptic plasticity in high-fat fed mice. Young Swiss mice were maintained on high-fat diet for 155 days, at which point half of the animals were switched to standard maintenance diet. Mice were subsequently injected with (d-Ala(2))GIP (25 nmol/kg bodyweight; b.i.d.) or saline vehicle for 28 days. Both dietary intervention and (d-Ala(2))GIP treatment were equally effective in restoring non-fasting glycaemic control (P
KW - Animals
KW - Blood Glucose
KW - Cognition Disorders
KW - Dietary Fats
KW - Gastric Inhibitory Polypeptide
KW - Glucose Intolerance
KW - Hippocampus
KW - Homeostasis
KW - Insulin
KW - Insulin Resistance
KW - Long-Term Potentiation
KW - Male
KW - Mice
KW - Obesity
KW - Receptors, Gastrointestinal Hormone
U2 - 10.1016/j.ejphar.2010.10.059
DO - 10.1016/j.ejphar.2010.10.059
M3 - Journal article
C2 - 21050845
VL - 650
SP - 688
EP - 693
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 2-3
ER -