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Quantification of βA4 protein deposition in the medial temporal lobe: a comparison of Alzheimer's disease and senile dementia of the Lewy body type

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Quantification of βA4 protein deposition in the medial temporal lobe: a comparison of Alzheimer's disease and senile dementia of the Lewy body type. / Gentleman, S M; Williams, B; Royston, M C et al.
In: Neuroscience Letters, Vol. 142, No. 1, 03.08.1992, p. 9-12.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Gentleman, SM, Williams, B, Royston, MC, Jagoe, R, Clinton, J, Perry, RH, Ince, PG, Allsop, D, Polak, JM & Roberts, GW 1992, 'Quantification of βA4 protein deposition in the medial temporal lobe: a comparison of Alzheimer's disease and senile dementia of the Lewy body type', Neuroscience Letters, vol. 142, no. 1, pp. 9-12. https://doi.org/10.1016/0304-3940(92)90608-A

APA

Gentleman, S. M., Williams, B., Royston, M. C., Jagoe, R., Clinton, J., Perry, R. H., Ince, P. G., Allsop, D., Polak, J. M., & Roberts, G. W. (1992). Quantification of βA4 protein deposition in the medial temporal lobe: a comparison of Alzheimer's disease and senile dementia of the Lewy body type. Neuroscience Letters, 142(1), 9-12. https://doi.org/10.1016/0304-3940(92)90608-A

Vancouver

Gentleman SM, Williams B, Royston MC, Jagoe R, Clinton J, Perry RH et al. Quantification of βA4 protein deposition in the medial temporal lobe: a comparison of Alzheimer's disease and senile dementia of the Lewy body type. Neuroscience Letters. 1992 Aug 3;142(1):9-12. doi: 10.1016/0304-3940(92)90608-A

Author

Gentleman, S M ; Williams, B ; Royston, M C et al. / Quantification of βA4 protein deposition in the medial temporal lobe : a comparison of Alzheimer's disease and senile dementia of the Lewy body type. In: Neuroscience Letters. 1992 ; Vol. 142, No. 1. pp. 9-12.

Bibtex

@article{586817c1d6dc467b9bac8fa91cbf6bea,
title = "Quantification of βA4 protein deposition in the medial temporal lobe: a comparison of Alzheimer's disease and senile dementia of the Lewy body type",
abstract = "The distribution of beta-amyloid protein (beta A4) was examined in the medial temporal lobes from cases of Alzheimer's disease (AD) (n = 13), senile dementia of Lewy body type (SDLT) (n = 12) and age matched controls (n = 9). Using a previously described image analysis technique the extent of beta A4 pathology was determined in ten distinct anatomical sites within the medial temporal lobe. AD and SDLT cases contained very similar amounts of beta A4 in the areas sampled and both contained significantly more beta A4 than the age matched controls, particularly in the dentate and parahippocampal gyri. The similarity of the beta A4 load in the two conditions is in contrast to reported differences in the number of neurofibrillary tangles which can be observed. It is suggested that AD and SDLT represent a spectrum of pathology which centres around the aberrant processing of the beta A4 precursor protein.",
keywords = "Aged, Alzheimer Disease, Amyloid beta-Peptides, Dementia, Female, Humans, Lewy Bodies, Male, Reference Values, Temporal Lobe, Tissue Distribution",
author = "Gentleman, {S M} and B Williams and Royston, {M C} and R Jagoe and J Clinton and Perry, {R H} and Ince, {P G} and D Allsop and Polak, {J M} and Roberts, {G W}",
year = "1992",
month = aug,
day = "3",
doi = "10.1016/0304-3940(92)90608-A",
language = "English",
volume = "142",
pages = "9--12",
journal = "Neuroscience Letters",
issn = "0304-3940",
publisher = "ELSEVIER IRELAND LTD",
number = "1",

}

RIS

TY - JOUR

T1 - Quantification of βA4 protein deposition in the medial temporal lobe

T2 - a comparison of Alzheimer's disease and senile dementia of the Lewy body type

AU - Gentleman, S M

AU - Williams, B

AU - Royston, M C

AU - Jagoe, R

AU - Clinton, J

AU - Perry, R H

AU - Ince, P G

AU - Allsop, D

AU - Polak, J M

AU - Roberts, G W

PY - 1992/8/3

Y1 - 1992/8/3

N2 - The distribution of beta-amyloid protein (beta A4) was examined in the medial temporal lobes from cases of Alzheimer's disease (AD) (n = 13), senile dementia of Lewy body type (SDLT) (n = 12) and age matched controls (n = 9). Using a previously described image analysis technique the extent of beta A4 pathology was determined in ten distinct anatomical sites within the medial temporal lobe. AD and SDLT cases contained very similar amounts of beta A4 in the areas sampled and both contained significantly more beta A4 than the age matched controls, particularly in the dentate and parahippocampal gyri. The similarity of the beta A4 load in the two conditions is in contrast to reported differences in the number of neurofibrillary tangles which can be observed. It is suggested that AD and SDLT represent a spectrum of pathology which centres around the aberrant processing of the beta A4 precursor protein.

AB - The distribution of beta-amyloid protein (beta A4) was examined in the medial temporal lobes from cases of Alzheimer's disease (AD) (n = 13), senile dementia of Lewy body type (SDLT) (n = 12) and age matched controls (n = 9). Using a previously described image analysis technique the extent of beta A4 pathology was determined in ten distinct anatomical sites within the medial temporal lobe. AD and SDLT cases contained very similar amounts of beta A4 in the areas sampled and both contained significantly more beta A4 than the age matched controls, particularly in the dentate and parahippocampal gyri. The similarity of the beta A4 load in the two conditions is in contrast to reported differences in the number of neurofibrillary tangles which can be observed. It is suggested that AD and SDLT represent a spectrum of pathology which centres around the aberrant processing of the beta A4 precursor protein.

KW - Aged

KW - Alzheimer Disease

KW - Amyloid beta-Peptides

KW - Dementia

KW - Female

KW - Humans

KW - Lewy Bodies

KW - Male

KW - Reference Values

KW - Temporal Lobe

KW - Tissue Distribution

U2 - 10.1016/0304-3940(92)90608-A

DO - 10.1016/0304-3940(92)90608-A

M3 - Journal article

C2 - 1407727

VL - 142

SP - 9

EP - 12

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 1

ER -