Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Raman spectroscopy of biological tissues
AU - Talari, A.C.S.
AU - Movasaghi, Z.
AU - Rehman, S.
AU - Rehman, I.U.
PY - 2015
Y1 - 2015
N2 - We previously published a comprehensive review paper reviewing the Raman spectroscopy of biological molecules. This research area has expanded rapidly, which warranted an update to the existing review paper by adding the recently reported studies in literature. This article reviews some of the recent advances of Raman spectroscopy in relation to biomedical applications starting from natural tissues to cancer biology. Raman spectroscopy, an optical molecular detective, is a vibrational spectroscopic technique that has potential not only in cancer diagnosis but also in understanding progression of the disease. This article summarizes some of the most widely observed peak frequencies and their assignments. The aim of this review is to develop a database of molecular fingerprints, which will facilitate researchers in identifying the chemical structure of the biological tissues including most of the significant peaks reported both in the normal and cancerous tissues. It has covered a variety of Raman approaches and its quantitative and qualitative biochemical information. In addition, it covers the use of Raman spectroscopy to analyse a variety of different malignancies including breast, brain, cervical, gastrointestinal, lung, oral, and skin cancer. Multivariate analysis approaches used in these studies have also been covered. Copyright © 2015 Taylor & Francis Group, LLC.
AB - We previously published a comprehensive review paper reviewing the Raman spectroscopy of biological molecules. This research area has expanded rapidly, which warranted an update to the existing review paper by adding the recently reported studies in literature. This article reviews some of the recent advances of Raman spectroscopy in relation to biomedical applications starting from natural tissues to cancer biology. Raman spectroscopy, an optical molecular detective, is a vibrational spectroscopic technique that has potential not only in cancer diagnosis but also in understanding progression of the disease. This article summarizes some of the most widely observed peak frequencies and their assignments. The aim of this review is to develop a database of molecular fingerprints, which will facilitate researchers in identifying the chemical structure of the biological tissues including most of the significant peaks reported both in the normal and cancerous tissues. It has covered a variety of Raman approaches and its quantitative and qualitative biochemical information. In addition, it covers the use of Raman spectroscopy to analyse a variety of different malignancies including breast, brain, cervical, gastrointestinal, lung, oral, and skin cancer. Multivariate analysis approaches used in these studies have also been covered. Copyright © 2015 Taylor & Francis Group, LLC.
KW - analysis of cancer tissues
KW - biological tissues
KW - characteristic peak assignments
KW - Raman spectroscopy
KW - Diagnosis
KW - Diseases
KW - Histology
KW - Medical applications
KW - Biochemical information
KW - Biological tissues
KW - Biomedical applications
KW - Cancer tissues
KW - Characteristic peaks
KW - Molecular fingerprint
KW - Multivariate analysis approaches
KW - Vibrational spectroscopic techniques
KW - Tissue
U2 - 10.1080/05704928.2014.923902
DO - 10.1080/05704928.2014.923902
M3 - Journal article
VL - 50
SP - 46
EP - 111
JO - APPLIED SPECTROSCOPY REVIEWS
JF - APPLIED SPECTROSCOPY REVIEWS
SN - 0570-4928
IS - 1
ER -