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Rapid hydrothermal flow synthesis and characterisation of carbonate and silicate-substituted calcium phosphates

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Rapid hydrothermal flow synthesis and characterisation of carbonate and silicate-substituted calcium phosphates. / Chaudhry, A.A.; Knowles, J.C.; Rehman, I. et al.
In: JOURNAL OF BIOMATERIALS APPLICATIONS, Vol. 28, No. 3, 2013, p. 448-461.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Chaudhry, AA, Knowles, JC, Rehman, I & Darr, JA 2013, 'Rapid hydrothermal flow synthesis and characterisation of carbonate and silicate-substituted calcium phosphates', JOURNAL OF BIOMATERIALS APPLICATIONS, vol. 28, no. 3, pp. 448-461. https://doi.org/10.1177/0885328212460289

APA

Chaudhry, A. A., Knowles, J. C., Rehman, I., & Darr, J. A. (2013). Rapid hydrothermal flow synthesis and characterisation of carbonate and silicate-substituted calcium phosphates. JOURNAL OF BIOMATERIALS APPLICATIONS, 28(3), 448-461. https://doi.org/10.1177/0885328212460289

Vancouver

Chaudhry AA, Knowles JC, Rehman I, Darr JA. Rapid hydrothermal flow synthesis and characterisation of carbonate and silicate-substituted calcium phosphates. JOURNAL OF BIOMATERIALS APPLICATIONS. 2013;28(3):448-461. doi: 10.1177/0885328212460289

Author

Chaudhry, A.A. ; Knowles, J.C. ; Rehman, I. et al. / Rapid hydrothermal flow synthesis and characterisation of carbonate and silicate-substituted calcium phosphates. In: JOURNAL OF BIOMATERIALS APPLICATIONS. 2013 ; Vol. 28, No. 3. pp. 448-461.

Bibtex

@article{dc213b72464b452caca9afc9af95f31a,
title = "Rapid hydrothermal flow synthesis and characterisation of carbonate and silicate-substituted calcium phosphates",
abstract = "A range of crystalline and nano-sized carbonate- and silicate-substituted hydroxyapatite has been successfully produced by using continuous hydrothermal flow synthesis technology. Ion-substituted calcium phosphates are better candidates for bone replacement applications (due to improved bioactivity) as compared to phase-pure hydroxyapatite. Urea was used as a carbonate source for synthesising phase pure carbonated hydroxyapatite (CO3-HA) with ≈5 wt% substituted carbonate content (sample 7.5CO3-HA) and it was found that a further increase in urea concentration in solution resulted in biphasic mixtures of carbonate-substituted hydroxyapatite and calcium carbonate. Transmission electron microscopy images revealed that the particle size of hydroxyapatite decreased with increasing urea concentration. Energy-dispersive X-ray spectroscopy result revealed a calcium deficient apatite with Ca:P molar ratio of 1.45 (±0.04) in sample 7.5CO3-HA. For silicate-substituted hydroxyapatite (SiO4-HA) silicon acetate was used as a silicate ion source. It was observed that a substitution threshold of ∼1.1 wt% exists for synthesis of SiO4-HA in the continuous hydrothermal flow synthesis system, which could be due to the decreasing yields with progressive increase in silicon acetate concentration. All the as-precipitated powders (without any additional heat treatments) were analysed using techniques including Transmission electron microscopy, X-ray powder diffraction, Differential scanning calorimetry, Thermogravimetric analysis, Raman spectroscopy and Fourier transform infrared spectroscopy. {\textcopyright} The Author(s) 2012 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.",
keywords = "bioactive, Calcium phosphates, carbonate, silicate, substituted, Calcium deficient apatites, Carbonate-substituted hydroxyapatite, Carbonated hydroxyapatites, Continuous hydrothermal flow synthesis, Energy dispersive x-ray spectroscopy, Transmission electron microscopy images, Calcium, Calcium phosphate, Carbonates, Differential scanning calorimetry, Energy dispersive spectroscopy, Fourier transform infrared spectroscopy, Hydrothermal synthesis, Hydroxyapatite, Ion sources, Metabolism, Silicates, Silicon, Thermogravimetric analysis, Transmission electron microscopy, Urea, Volatile fatty acids, X ray powder diffraction, Carbonation, acetic acid, apatite, calcium, calcium carbonate, calcium phosphate, carbonic acid, hydroxyapatite, silicon, silicon acetate, unclassified drug, urea, animal experiment, animal tissue, article, concentration (parameters), controlled study, differential scanning calorimetry, energy dispersive X ray spectroscopy, femur condyle, hydrothermal flow synthesis, infrared spectroscopy, nonhuman, particle size, rabbit, Raman spectrometry, roentgen spectroscopy, synthesis, thermogravimetry, transmission electron microscopy, Calcium Phosphates, Microscopy, Electron, Transmission, Particle Size",
author = "A.A. Chaudhry and J.C. Knowles and I. Rehman and J.A. Darr",
year = "2013",
doi = "10.1177/0885328212460289",
language = "English",
volume = "28",
pages = "448--461",
journal = "JOURNAL OF BIOMATERIALS APPLICATIONS",
issn = "0885-3282",
publisher = "SAGE Publications Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Rapid hydrothermal flow synthesis and characterisation of carbonate and silicate-substituted calcium phosphates

AU - Chaudhry, A.A.

AU - Knowles, J.C.

AU - Rehman, I.

AU - Darr, J.A.

PY - 2013

Y1 - 2013

N2 - A range of crystalline and nano-sized carbonate- and silicate-substituted hydroxyapatite has been successfully produced by using continuous hydrothermal flow synthesis technology. Ion-substituted calcium phosphates are better candidates for bone replacement applications (due to improved bioactivity) as compared to phase-pure hydroxyapatite. Urea was used as a carbonate source for synthesising phase pure carbonated hydroxyapatite (CO3-HA) with ≈5 wt% substituted carbonate content (sample 7.5CO3-HA) and it was found that a further increase in urea concentration in solution resulted in biphasic mixtures of carbonate-substituted hydroxyapatite and calcium carbonate. Transmission electron microscopy images revealed that the particle size of hydroxyapatite decreased with increasing urea concentration. Energy-dispersive X-ray spectroscopy result revealed a calcium deficient apatite with Ca:P molar ratio of 1.45 (±0.04) in sample 7.5CO3-HA. For silicate-substituted hydroxyapatite (SiO4-HA) silicon acetate was used as a silicate ion source. It was observed that a substitution threshold of ∼1.1 wt% exists for synthesis of SiO4-HA in the continuous hydrothermal flow synthesis system, which could be due to the decreasing yields with progressive increase in silicon acetate concentration. All the as-precipitated powders (without any additional heat treatments) were analysed using techniques including Transmission electron microscopy, X-ray powder diffraction, Differential scanning calorimetry, Thermogravimetric analysis, Raman spectroscopy and Fourier transform infrared spectroscopy. © The Author(s) 2012 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

AB - A range of crystalline and nano-sized carbonate- and silicate-substituted hydroxyapatite has been successfully produced by using continuous hydrothermal flow synthesis technology. Ion-substituted calcium phosphates are better candidates for bone replacement applications (due to improved bioactivity) as compared to phase-pure hydroxyapatite. Urea was used as a carbonate source for synthesising phase pure carbonated hydroxyapatite (CO3-HA) with ≈5 wt% substituted carbonate content (sample 7.5CO3-HA) and it was found that a further increase in urea concentration in solution resulted in biphasic mixtures of carbonate-substituted hydroxyapatite and calcium carbonate. Transmission electron microscopy images revealed that the particle size of hydroxyapatite decreased with increasing urea concentration. Energy-dispersive X-ray spectroscopy result revealed a calcium deficient apatite with Ca:P molar ratio of 1.45 (±0.04) in sample 7.5CO3-HA. For silicate-substituted hydroxyapatite (SiO4-HA) silicon acetate was used as a silicate ion source. It was observed that a substitution threshold of ∼1.1 wt% exists for synthesis of SiO4-HA in the continuous hydrothermal flow synthesis system, which could be due to the decreasing yields with progressive increase in silicon acetate concentration. All the as-precipitated powders (without any additional heat treatments) were analysed using techniques including Transmission electron microscopy, X-ray powder diffraction, Differential scanning calorimetry, Thermogravimetric analysis, Raman spectroscopy and Fourier transform infrared spectroscopy. © The Author(s) 2012 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

KW - bioactive

KW - Calcium phosphates

KW - carbonate

KW - silicate

KW - substituted

KW - Calcium deficient apatites

KW - Carbonate-substituted hydroxyapatite

KW - Carbonated hydroxyapatites

KW - Continuous hydrothermal flow synthesis

KW - Energy dispersive x-ray spectroscopy

KW - Transmission electron microscopy images

KW - Calcium

KW - Calcium phosphate

KW - Carbonates

KW - Differential scanning calorimetry

KW - Energy dispersive spectroscopy

KW - Fourier transform infrared spectroscopy

KW - Hydrothermal synthesis

KW - Hydroxyapatite

KW - Ion sources

KW - Metabolism

KW - Silicates

KW - Silicon

KW - Thermogravimetric analysis

KW - Transmission electron microscopy

KW - Urea

KW - Volatile fatty acids

KW - X ray powder diffraction

KW - Carbonation

KW - acetic acid

KW - apatite

KW - calcium

KW - calcium carbonate

KW - calcium phosphate

KW - carbonic acid

KW - hydroxyapatite

KW - silicon

KW - silicon acetate

KW - unclassified drug

KW - urea

KW - animal experiment

KW - animal tissue

KW - article

KW - concentration (parameters)

KW - controlled study

KW - differential scanning calorimetry

KW - energy dispersive X ray spectroscopy

KW - femur condyle

KW - hydrothermal flow synthesis

KW - infrared spectroscopy

KW - nonhuman

KW - particle size

KW - rabbit

KW - Raman spectrometry

KW - roentgen spectroscopy

KW - synthesis

KW - thermogravimetry

KW - transmission electron microscopy

KW - Calcium Phosphates

KW - Microscopy, Electron, Transmission

KW - Particle Size

U2 - 10.1177/0885328212460289

DO - 10.1177/0885328212460289

M3 - Journal article

VL - 28

SP - 448

EP - 461

JO - JOURNAL OF BIOMATERIALS APPLICATIONS

JF - JOURNAL OF BIOMATERIALS APPLICATIONS

SN - 0885-3282

IS - 3

ER -