Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system

Biomedical and Life Sciences

Text available via DOI:

https://doi.org/10.1097/WNR.0b013e32832fbf14
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Keywords

Animals, Brain, Dendrites, Immunohistochemistry, Male, Mice, Mice, Inbred C57BL, Neuroglia, Neurons, Purkinje Cells, Pyramidal Cells, Receptors, Glucagon

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Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system. / Hamilton, Alison ; Hölscher, Christian.
In: NeuroReport, Vol. 20, No. 13, 26.08.2009, p. 1161-1166.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{f06c3d4e470f46c8a97db583ac71f727,

title = "Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system",

abstract = "Glucagon-like-peptide-1 is an incretin hormone that also has neuroprotective properties. Here we analyse where glucagon-like-peptide-1 receptors are expressed in the brain. The receptor is found only on neurons, not on glia cells. The pyramidal cell layer of the CA region and the granule cell layer of the dentate gyrus in the hippocampus show intense staining. In the neocortex, larger pyramidal neurons express the receptor. In the cerebellum, only Purkinje neurons express the receptor. Dendrites of larger neurons were stained; in particular, pyramidal cells in area CA and dendrites of Purkinje cells. The fact that the receptor is located on neurons and dendrites suggests that the neuroprotective action is caused by the modulation of neuronal excitation.",

keywords = "Animals, Brain, Dendrites, Immunohistochemistry, Male, Mice, Mice, Inbred C57BL, Neuroglia, Neurons, Purkinje Cells, Pyramidal Cells, Receptors, Glucagon",

author = "Alison Hamilton and Christian H{\"o}lscher",

year = "2009",

month = aug,

day = "26",

doi = "10.1097/WNR.0b013e32832fbf14",

language = "English",

volume = "20",

pages = "1161--1166",

journal = "NeuroReport",

issn = "0959-4965",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "13",

}

RIS

TY - JOUR

T1 - Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system

AU - Hamilton, Alison

AU - Hölscher, Christian

PY - 2009/8/26

Y1 - 2009/8/26

N2 - Glucagon-like-peptide-1 is an incretin hormone that also has neuroprotective properties. Here we analyse where glucagon-like-peptide-1 receptors are expressed in the brain. The receptor is found only on neurons, not on glia cells. The pyramidal cell layer of the CA region and the granule cell layer of the dentate gyrus in the hippocampus show intense staining. In the neocortex, larger pyramidal neurons express the receptor. In the cerebellum, only Purkinje neurons express the receptor. Dendrites of larger neurons were stained; in particular, pyramidal cells in area CA and dendrites of Purkinje cells. The fact that the receptor is located on neurons and dendrites suggests that the neuroprotective action is caused by the modulation of neuronal excitation.

AB - Glucagon-like-peptide-1 is an incretin hormone that also has neuroprotective properties. Here we analyse where glucagon-like-peptide-1 receptors are expressed in the brain. The receptor is found only on neurons, not on glia cells. The pyramidal cell layer of the CA region and the granule cell layer of the dentate gyrus in the hippocampus show intense staining. In the neocortex, larger pyramidal neurons express the receptor. In the cerebellum, only Purkinje neurons express the receptor. Dendrites of larger neurons were stained; in particular, pyramidal cells in area CA and dendrites of Purkinje cells. The fact that the receptor is located on neurons and dendrites suggests that the neuroprotective action is caused by the modulation of neuronal excitation.

KW - Animals

KW - Brain

KW - Dendrites

KW - Immunohistochemistry

KW - Male

KW - Mice

KW - Mice, Inbred C57BL

KW - Neuroglia

KW - Neurons

KW - Purkinje Cells

KW - Pyramidal Cells

KW - Receptors, Glucagon

U2 - 10.1097/WNR.0b013e32832fbf14

DO - 10.1097/WNR.0b013e32832fbf14

M3 - Journal article

C2 - 19617854

VL - 20

SP - 1161

EP - 1166

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 13

ER -

Research

Text available via DOI:

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