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Recovery of erythromycin from aqueous solutions with an ionic liquid and high-pressure carbon dioxide

Research output: Contribution to journalJournal article

Published

Journal publication date15/07/2011
JournalChemical Engineering Journal
Journal number3
Volume171
Number of pages8
Pages904-911
Original languageEnglish

Abstract

Recovery of erythromycin from aqueous solutions was studied in two steps: (i) single- and multi-stage extraction of erythromycin from an aqueous solution with a hydrophobic ionic liquid, 1-butyl-1-methylpyrrolidinium bis(trifluoromethylsulfonyl)imide [BMPyrrol][Tf(2)N], as a function of pH and feed to solvent volume ratio, and (ii) high-pressure CO(2) extraction of erythromycin from the ionic liquid, as a function of pressure, temperature and presence of water. Furthermore, data on the mutual solubilities of the hydrophobic ionic liquid and water, as well as on the solubility of erythromycin in [BMPyrrol][Tf(2)N], were obtained. The chemical stability of erythromycin in water-free and water saturated ionic liquid was tested.

These results allowed the evaluation of the coupling of liquid-liquid and high-pressure CO(2) extractions. (C) 2011 Elsevier B.V. All rights reserved.