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Re-Emergence of a Novel H5N1 Avian Influenza Virus Variant Subclade 2.2.1.1 in Egypt During 2014

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Re-Emergence of a Novel H5N1 Avian Influenza Virus Variant Subclade 2.2.1.1 in Egypt During 2014. / Rohaim, M. A.; El-Naggar, R. F.; Hamoud, M M; Nasr, S A; Ismael, E; Laban, S E; Ahmed, H A; Munir, Muhammad.

In: Transboundary and Emerging Diseases, Vol. 64, No. 4, 08.2017, p. 1306-1312.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Rohaim, MA, El-Naggar, RF, Hamoud, MM, Nasr, SA, Ismael, E, Laban, SE, Ahmed, HA & Munir, M 2017, 'Re-Emergence of a Novel H5N1 Avian Influenza Virus Variant Subclade 2.2.1.1 in Egypt During 2014', Transboundary and Emerging Diseases, vol. 64, no. 4, pp. 1306-1312. https://doi.org/10.1111/tbed.12472

APA

Rohaim, M. A., El-Naggar, R. F., Hamoud, M. M., Nasr, S. A., Ismael, E., Laban, S. E., Ahmed, H. A., & Munir, M. (2017). Re-Emergence of a Novel H5N1 Avian Influenza Virus Variant Subclade 2.2.1.1 in Egypt During 2014. Transboundary and Emerging Diseases, 64(4), 1306-1312. https://doi.org/10.1111/tbed.12472

Vancouver

Rohaim MA, El-Naggar RF, Hamoud MM, Nasr SA, Ismael E, Laban SE et al. Re-Emergence of a Novel H5N1 Avian Influenza Virus Variant Subclade 2.2.1.1 in Egypt During 2014. Transboundary and Emerging Diseases. 2017 Aug;64(4):1306-1312. https://doi.org/10.1111/tbed.12472

Author

Rohaim, M. A. ; El-Naggar, R. F. ; Hamoud, M M ; Nasr, S A ; Ismael, E ; Laban, S E ; Ahmed, H A ; Munir, Muhammad. / Re-Emergence of a Novel H5N1 Avian Influenza Virus Variant Subclade 2.2.1.1 in Egypt During 2014. In: Transboundary and Emerging Diseases. 2017 ; Vol. 64, No. 4. pp. 1306-1312.

Bibtex

@article{d85a71362aa8424fa713d7c806cfa6a6,
title = "Re-Emergence of a Novel H5N1 Avian Influenza Virus Variant Subclade 2.2.1.1 in Egypt During 2014",
abstract = "Large-scale surveillance is crucial for understanding the evolution and the emergence of avian influenza viruses (AIVs) in endemic areas. Circulation of highly pathogenic avian influenza (HPAI) subtype H5N1 is continuously causing significant economic losses to the Egyptian poultry industry and is a threat to public health. In this report, a HPAI H5N1 strain (A/chicken/Egypt/Fadllah-7/2014) was detected from a vaccinated flock showing clinical signs of infection. Genetic characterization of the isolate indicated a high level of nucleotide identity (95-98%) with variant and classical groups of H5N1. Moreover, multiple-nucleotide and amino acid alignments revealed several prominent and characteristic substitutions in the surface glycoprotein, which may have biological relevance to the pathobiology of the virus. Phylogenetic analysis demonstrated that the reported isolate closely relates to H5N1 AIVs subclade 2.2.1.1 in spite of no reports of this subclade since 2011 from AI reported cases in Egyptian avian species. In conclusion, our results highlight the re-emergence of a novel H5N1 AIV variant subclade 2.2.1.1 that could escape immunity induced by vaccines. This discovery illustrates the importance of continuous monitoring of poultry in this country for controlling AIV including identifying sources of vaccine seed viruses.",
keywords = "Animals, Chickens, Egypt, Hemagglutinin Glycoproteins, Influenza Virus, Influenza A Virus, H5N1 Subtype, Influenza in Birds, Phylogeny, Poultry Diseases, Sequence Analysis, RNA, Journal Article",
author = "Rohaim, {M. A.} and El-Naggar, {R. F.} and Hamoud, {M M} and Nasr, {S A} and E Ismael and Laban, {S E} and Ahmed, {H A} and Muhammad Munir",
note = "{\textcopyright} 2016 Blackwell Verlag GmbH.",
year = "2017",
month = aug,
doi = "10.1111/tbed.12472",
language = "English",
volume = "64",
pages = "1306--1312",
journal = "Transboundary and Emerging Diseases",
issn = "1865-1674",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Re-Emergence of a Novel H5N1 Avian Influenza Virus Variant Subclade 2.2.1.1 in Egypt During 2014

AU - Rohaim, M. A.

AU - El-Naggar, R. F.

AU - Hamoud, M M

AU - Nasr, S A

AU - Ismael, E

AU - Laban, S E

AU - Ahmed, H A

AU - Munir, Muhammad

N1 - © 2016 Blackwell Verlag GmbH.

PY - 2017/8

Y1 - 2017/8

N2 - Large-scale surveillance is crucial for understanding the evolution and the emergence of avian influenza viruses (AIVs) in endemic areas. Circulation of highly pathogenic avian influenza (HPAI) subtype H5N1 is continuously causing significant economic losses to the Egyptian poultry industry and is a threat to public health. In this report, a HPAI H5N1 strain (A/chicken/Egypt/Fadllah-7/2014) was detected from a vaccinated flock showing clinical signs of infection. Genetic characterization of the isolate indicated a high level of nucleotide identity (95-98%) with variant and classical groups of H5N1. Moreover, multiple-nucleotide and amino acid alignments revealed several prominent and characteristic substitutions in the surface glycoprotein, which may have biological relevance to the pathobiology of the virus. Phylogenetic analysis demonstrated that the reported isolate closely relates to H5N1 AIVs subclade 2.2.1.1 in spite of no reports of this subclade since 2011 from AI reported cases in Egyptian avian species. In conclusion, our results highlight the re-emergence of a novel H5N1 AIV variant subclade 2.2.1.1 that could escape immunity induced by vaccines. This discovery illustrates the importance of continuous monitoring of poultry in this country for controlling AIV including identifying sources of vaccine seed viruses.

AB - Large-scale surveillance is crucial for understanding the evolution and the emergence of avian influenza viruses (AIVs) in endemic areas. Circulation of highly pathogenic avian influenza (HPAI) subtype H5N1 is continuously causing significant economic losses to the Egyptian poultry industry and is a threat to public health. In this report, a HPAI H5N1 strain (A/chicken/Egypt/Fadllah-7/2014) was detected from a vaccinated flock showing clinical signs of infection. Genetic characterization of the isolate indicated a high level of nucleotide identity (95-98%) with variant and classical groups of H5N1. Moreover, multiple-nucleotide and amino acid alignments revealed several prominent and characteristic substitutions in the surface glycoprotein, which may have biological relevance to the pathobiology of the virus. Phylogenetic analysis demonstrated that the reported isolate closely relates to H5N1 AIVs subclade 2.2.1.1 in spite of no reports of this subclade since 2011 from AI reported cases in Egyptian avian species. In conclusion, our results highlight the re-emergence of a novel H5N1 AIV variant subclade 2.2.1.1 that could escape immunity induced by vaccines. This discovery illustrates the importance of continuous monitoring of poultry in this country for controlling AIV including identifying sources of vaccine seed viruses.

KW - Animals

KW - Chickens

KW - Egypt

KW - Hemagglutinin Glycoproteins, Influenza Virus

KW - Influenza A Virus, H5N1 Subtype

KW - Influenza in Birds

KW - Phylogeny

KW - Poultry Diseases

KW - Sequence Analysis, RNA

KW - Journal Article

U2 - 10.1111/tbed.12472

DO - 10.1111/tbed.12472

M3 - Journal article

C2 - 26801667

VL - 64

SP - 1306

EP - 1312

JO - Transboundary and Emerging Diseases

JF - Transboundary and Emerging Diseases

SN - 1865-1674

IS - 4

ER -